Potential involvement of chemicals in liver cancer progression: An alternative toxicological approach combining biomarkers and innovative technologies

Low prevalence of anti‐xenobiotic antibodies among the occupationally exposed individuals is associated with a high risk of cancer

“…Carbendazim (methyl‐2‐benzimidazole carbamate) is a broad‐spectrum benzimidazole fungicide used in agricultural industry. It has been shown to induce hepatocarcinoma as well as produces teratogenic effects . Carbendazim can produce aneuploidy by inhibiting the formation of microtubules during cell division .…”

“…It has been shown to induce hepatocarcinoma as well as produces teratogenic effects. 30,31 Carbendazim can produce aneuploidy by inhibiting the formation of microtubules during cell division. 32,33 The cancer patients exhibited sufficiently (p < 0.001) lower Ab titer against carbendazim, as compared to their healthy household contacts ( Figure 4C).…”

High-content screening imaging and real-time cellular impedance monitoring for the assessment of chemical’s bio-activation with regards hepatotoxicity

“…for cellular impacts of compounds on liver cells, especially on the HepG2 cell line already tested during our last investigations (Peyre et al, 2014). Moreover, impedance measurements in real-time condition constitute a unique tool to study the adaptative response of the cells to a chemical stress.…”