Potential Mechanisms Involved in Palmitoylethanolamide-Induced Vasodepressor Effects in Rats

Marichal‐Cancino, Bruno A.; González‐Hernández, Abimael; MaassenVanDenBrink, Antoinette; Juan, Eduardo Ramírez-San; Villalón, Carlos M.

doi:10.1159/000506158

Cited by 18 publications

(11 citation statements)

References 46 publications

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“…PEA also inhibits vasopressor responses to exogenous noradrenaline or sympathetic stimulation, which induces hypotension. The PEA action is reported to be mediated by prejunctional and vascular CB 1 , TRPV1, and probably GPR55 [94].…”

Section: Other Effectsmentioning

confidence: 99%

GPR119 and GPR55 as Receptors for Fatty Acid Ethanolamides, Oleoylethanolamide and Palmitoylethanolamide

2021

IJMS

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Oleoylethanolamide and palmitoylethanolamide are members of the fatty acid ethanolamide family, also known as acylethanolamides. Their physiological effects, including glucose homeostasis, anti-inflammation, anti-anaphylactic, analgesia, and hypophagia, have been reported. They have affinity for different receptor proteins, including nuclear receptors such as PPARα, channels such as TRPV1, and membrane receptors such as GPR119 and GPR55. In the present review, the pathophysiological functions of fatty acid ethanolamides have been discussed from the perspective of receptor pharmacology and drug discovery.

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Section: Other Effectsmentioning

confidence: 99%

GPR119 and GPR55 as Receptors for Fatty Acid Ethanolamides, Oleoylethanolamide and Palmitoylethanolamide

2021

IJMS

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“…Indeed, the interruption of sympathetic activity seems to involve both monoaminergic auto-and hetero-receptors [65,66]. Interestingly, the endocannabinoid [67][68][69] and opioid systems [70] are also involved in the modulation of cardiovascular sympathetic and sensory drives.…”

Section: Physiology Of the Periaqueductal Graymentioning

confidence: 99%

The Periaqueductal Gray and Its Extended Participation in Drug Addiction Phenomena

et al. 2021

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The periaqueductal gray (PAG) is a complex mesencephalic structure involved in the integration and execution of active and passive self-protective behaviors against imminent threats, such as immobility or flight from a predator. PAG activity is also associated with the integration of responses against physical discomfort (e.g., anxiety, fear, pain, and disgust) which occurs prior an imminent attack, but also during withdrawal from drugs such as morphine and cocaine. The PAG sends and receives projections to and from other well-documented nuclei linked to the phenomenon of drug addiction including: (i) the ventral tegmental area; (ii) extended amygdala; (iii) medial prefrontal cortex; (iv) pontine nucleus; (v) bed nucleus of the stria terminalis; and (vi) hypothalamus. Preclinical models have suggested that the PAG contributes to the modulation of anxiety, fear, and nociception (all of which may produce physical discomfort) linked with chronic exposure to drugs of abuse. Withdrawal produced by the major pharmacological classes of drugs of abuse is mediated through actions that include participation of the PAG. In support of this, there is evidence of functional, pharmacological, molecular. And/or genetic alterations in the PAG during the impulsive/compulsive intake or withdrawal from a drug. Due to its small size, it is difficult to assess the anatomical participation of the PAG when using classical neuroimaging techniques, so its physiopathology in drug addiction has been underestimated and poorly documented. In this theoretical review, we discuss the involvement of the PAG in drug addiction mainly via its role as an integrator of responses to the physical discomfort associated with drug withdrawal.

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“…, cannabinoid, purinergic, cholinergic, etc . ; not considered in this review [ 83 - 86 ]) autoreceptors and heteroreceptors may positively and/or negatively modulate the sympathetic outflow. Autonomic sympathetic perivascular fibers express a wide spectrum of monoaminergic receptors ( e.g.…”

Section: Monoaminergic Receptors Modulating the Sympathetic Perivascumentioning

confidence: 99%

Monoaminergic Receptors as Modulators of the Perivascular Sympathetic and Sensory CGRPergic Outflows

Marichal‐Cancino

González‐Hernández

Muñoz-Islas

et al. 2020

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: Blood pressure is a highly controlled cardiovascular parameter that normally guarantees an adequate blood supply to all body tissues. This parameter is mainly regulated by vascular peripheral resistance and is maintained by local mediators (i.e., autacoids), and by the nervous and endocrine systems. Regarding the nervous system, blood pressure can be modulated at central level by regulating the autonomic output. However, at peripheral level there exists a modulation by activation of prejunctional monoaminergic receptors in autonomic- or sensory-perivascular fibers. These modulatory mechanisms on resistance blood vessels exert an effect on the release of neuroactive substances from the autonomic or sensory fibers that modify blood pressure. Certainly, resistance blood vessels are innervated by perivascular: (i) autonomic sympathetic fibers (producing vasoconstriction mainly by noradrenaline release); and (ii) peptidergic sensory fibers [producing vasodilatation mainly by calcitonin gene-related peptide (CGRP) release]. In the last years, by using pithed rats, several monoaminergic mechanisms for controlling both the sympathetic and sensory perivascular outflows have been elucidated. Additionally, several studies have shown the functions of many monoaminergic auto-receptors and hetero-receptors expressed on perivascular fibers that modulate neurotransmitter release. On this basis, the present review: (i) summarizes the modulation of the peripheral vascular tone by adrenergic, serotoninergic, dopaminergic, and histaminergic receptors on perivascular autonomic (sympathetic) and sensory fibers, and (ii) highlights that these monoaminergic receptors are potential therapeutic targets for the development of novel medications to treat cardiovascular diseases (with some of them explored in clinical trials or already in clinical use).

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Potential Mechanisms Involved in Palmitoylethanolamide-Induced Vasodepressor Effects in Rats

Cited by 18 publications

References 46 publications

GPR119 and GPR55 as Receptors for Fatty Acid Ethanolamides, Oleoylethanolamide and Palmitoylethanolamide

GPR119 and GPR55 as Receptors for Fatty Acid Ethanolamides, Oleoylethanolamide and Palmitoylethanolamide

The Periaqueductal Gray and Its Extended Participation in Drug Addiction Phenomena

Monoaminergic Receptors as Modulators of the Perivascular Sympathetic and Sensory CGRPergic Outflows

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