2021
DOI: 10.3390/biom11101539
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Potential Mechanisms of Plant-Derived Natural Products in the Treatment of Cervical Cancer

Abstract: Cervical cancer is the second most common gynecological malignancy globally; it seriously endangers women’s health because of its high morbidity and mortality. Conventional treatments are prone to drug resistance, recurrence and metastasis. Therefore, there is an urgent need to develop new drugs with high efficacy and low side effects to prevent and treat cervical cancer. In recent years, plant-derived natural products have been evaluated as potential anticancer drugs that preferentially kill tumor cells witho… Show more

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Cited by 20 publications
(13 citation statements)
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References 183 publications
(180 reference statements)
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“…Excess free radicals were removed in certain doses. Puerarin as reported improved the tissue damage induced via ROS, then increased the ability to fight tumors (He et al, 2021).…”
Section: Flavoniodsmentioning
confidence: 94%
“…Excess free radicals were removed in certain doses. Puerarin as reported improved the tissue damage induced via ROS, then increased the ability to fight tumors (He et al, 2021).…”
Section: Flavoniodsmentioning
confidence: 94%
“…Methyl jasmonate treatment significantly increased the total anthocyanin and phenol contents in blackberry fruits; inhibited cell proliferation in human lungs, A549 cells, and HL-60 leukemia cells; and induced the apoptosis of HL-60 cells [ 21 ]. Cyanidin 3-O-glucoside (C3G) may increase cisplatin’s antitumor activity to reduce the adverse effects of chemotherapy in cervical cancer [ 22 ]. Several mechanisms have been proposed to mediate the anticancer properties of anthocyanins.…”
Section: Introductionmentioning
confidence: 99%
“…Several compounds derived from natural products, such as Genistein, Puerarin, Formononetin, Cyanidin Anthocyanins, Curcumin, Emodin, Epifriedelanol, Mitomycin C, and Piperine, induce apoptosis in cervical cancers [6,43]. Activation of apoptosis is used as an anticancer mechanism in cancer therapy research [6].…”
Section: Discussionmentioning
confidence: 99%