Potential mechanisms of tremor tolerance induced in rats by the repeated administration of total alkaloid extracts from the seeds of Peganum harmala Linn

Wang, Youxu; Wang, Hanxue; Zhang, Liuhong; Zhang, Yunpeng; Deng, Gang; Li, Shuping; Cao, Ning; Guan, Huida; Cheng, Xuemei; Wang, Changhong

doi:10.1016/j.jep.2020.113183

Cited by 4 publications

(1 citation statement)

References 52 publications

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“…Berrougui et al [69] suggested that P. harmala compounds could be a major source of compounds that inhibit low density lipoprotein (LDL) oxidative modification induced by copper. The seeds of P. harmala have been widely used for the treatment of nervous, cardiovascular, gastrointestinal, respiratory and endocrine diseases and some human aliments [70,71]. Harmaline has multiple pharmacological impacts such as antileishmanial, antimicrobial, antiplatelet, antiplasmodial, antitumoral, hypothermic and vasorelaxant activity [72][73][74].…”

Section: Medicinal Uses and Potential Health Benefits In Traditional mentioning

confidence: 99%

Improving health benefits with considering traditional and modern health benefits of Peganum harmala

2021

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Background Medicinal plants are potential source of natural products that play an important role in preventing different human diseases. P. harmala is used traditionally as emmenagogue and an abortifacient agent in the Middle East, North of Africa and West of China. It belongs to the family of Zygophyllaceae and it is a wild growing flowering plant. Its seeds are main medicinal part of the plant. Methods The current searching was done by the keywords in main indexing systems including PubMed/MEDLINE, Scopus, and Institute for Scientific Information Web of Science as well as the search engine of Google Scholar. The keywords were wild rue, traditional medicine, Harman, health benefits, and pharmaceutical science. Results The most important uses of P. harmala in traditional pharmaceutical sciences are in cardiovascular, gasterointestinal, nervous, endocrine, neoplasm and tumors, pain relieving, organisms, diabetes, respiratory, disinfectant, anti-pyretic, skin and hair, rheumatism, arthritis and inflammation, and ulcers. Pharmacological effects of P. harmala are in cardiovascular system, nervous system, antimicrobial effects, antineoplasm, nervous system, endocrine, gastrointestinal effects, osteocytes, endocrine and respiratory system. Phenolic compounds are the main reason of antioxidant capacity. Conclusions Due to its pharmacological activities, P. harmala is a high potential medicinal herb and the suggestion is to increases by doing research in efficacy and safety.

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Section: Medicinal Uses and Potential Health Benefits In Traditional mentioning

confidence: 99%

Improving health benefits with considering traditional and modern health benefits of Peganum harmala

2021

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AMPA receptor neurotransmission and therapeutic applications: A comprehensive review of their multifaceted modulation

Qneibi,

Bdir,

Bdair

et al. 2024

European Journal of Medicinal Chemistry

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Effects and mechanisms of harmine on ameliorating ethanol-induced memory impairment

Xie,

Liu,

Dang

et al. 2025

Journal of Ethnopharmacology

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Potential mechanisms of tremor tolerance induced in rats by the repeated administration of total alkaloid extracts from the seeds of Peganum harmala Linn

Cited by 4 publications

References 52 publications

Improving health benefits with considering traditional and modern health benefits of Peganum harmala

Improving health benefits with considering traditional and modern health benefits of Peganum harmala

AMPA receptor neurotransmission and therapeutic applications: A comprehensive review of their multifaceted modulation

Effects and mechanisms of harmine on ameliorating ethanol-induced memory impairment

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