Potential medicinal effects and applications of stevia constituents

Talevi, Alan

doi:10.1007/s11101-021-09753-5

Cited by 13 publications

(8 citation statements)

References 85 publications

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“…However, among them, steviol glycosides raised the most questions about their potential for use in human treatment therapies, mainly due to insufficient in-depth research into their mechanisms of action and inconsistencies in clinical trial results. Talevi (2021) stated that a potential reason for inconclusive outcomes in clinical trials regarding the antidiabetic effects of steviol glycosides lies in their biopharmaceutical and/or pharmacokinetic aspects, such as an intrinsic pharmacological activity [ 107 ]. Therefore, the potential use of these compounds in human therapeutics will require careful selection of the dose, treatment duration, and appropriate route of administration.…”

Section: Discussionmentioning

confidence: 99%

Steviol Glycoside, L-Arginine, and Chromium(III) Supplementation Attenuates Abnormalities in Glucose Metabolism in Streptozotocin-Induced Mildly Diabetic Rats Fed a High-Fat Diet

et al. 2022

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Stevia rebaudiana Bertoni and its glycosides are believed to exhibit several health-promoting properties. Recently, the mechanisms of the anti-diabetic effects of steviol glycosides (SG) have been the subject of intense research. The following study aims to evaluate the results of SG (stevioside (ST) and rebaudioside A (RA)) combined with L-arginine (L-Arg) and chromium(III) (CrIII) supplementation in streptozotocin- (STZ) induced mild type 2 diabetic rats fed a high-fat diet (HFD), with particular emphasis on carbohydrate and lipid metabolisms. The experiment was carried out on 110 male Wistar rats, 100 of which were fed an HFD to induce insulin resistance, followed by an intraperitoneal injection of streptozotocin to induce mild type 2 diabetes. After confirmation of hyperglycemia, the rats were divided into groups. Three groups served as controls: diabetic untreated, diabetic treated with metformin (300 mg/kg BW), and healthy group. Eight groups were fed an HFD enriched with stevioside or rebaudioside A (2500 mg/kg BW) combined with L-arginine (2000 or 4000 mg/kg BW) and Cr(III) (1 or 5 mg/kg BW) for six weeks. The results showed that supplementation with SG (ST and RA) combined with L-arg and Cr(III) could improve blood glucose levels in rats with mild type 2 diabetes. Furthermore, ST was more effective in improving blood glucose levels, insulin resistance indices, and very low-density lipoprotein cholesterol (VLDL-C) concentrations than RA. Although L-arg and Cr(III) supplementation did not independently affect most blood carbohydrate and lipid indices, it further improved some biomarkers when combined, particularly with ST. Notably, the beneficial impact of ST on the homeostatic model assessment–insulin resistance (HOMA-IR) and on the quantitative insulin-sensitivity check index (QUICKI) was strengthened when mixed with a high dose of L-arg, while its impact on antioxidant status was improved when combined with a high dose of Cr(III) in rats with mild type 2 diabetes. In conclusion, these results suggest that supplementary stevioside combined with L-arginine and Cr(III) has therapeutic potential for mild type 2 diabetes. However, further studies are warranted to confirm these effects in other experimental models and humans.

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Section: Discussionmentioning

confidence: 99%

Steviol Glycoside, L-Arginine, and Chromium(III) Supplementation Attenuates Abnormalities in Glucose Metabolism in Streptozotocin-Induced Mildly Diabetic Rats Fed a High-Fat Diet

et al. 2022

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“…For the former, steviol glucuronide is excreted primarily in the feces via the biliary. However, in humans, steviol is excreted in the urine (EFSA, 2010(EFSA, , 2015Talevi, 2022). For example, a human study showed that after an oral administration of stevioside for 72 h, the excretion of steviol metabolites in urine and feces accounted for 62% and 5.2% of the total intake, respectively (Wheeler et al, 2008).…”

Section: Kinetic and Metabolism Studies About Rebaudioside Amentioning

confidence: 99%

“…In addition, many in-depth studies have been conducted to obtain SvGls from stevia leaves, and new technologies have been developed and commercialized to reduce production costs. According to the statistics, the market value of stevia is forecasted to reach approximately 771.5 million US dollars by 2022 (Stevia's global market value, 2017-2022. Currently, rebaudioside A has become the first commercially available SvGls and has been recognized by many consumers.…”

Section: Introductionmentioning

confidence: 99%

Natural and low‐caloric rebaudioside A as a substitute for dietary sugars: A comprehensive review

Wang

Luo

Chen³

et al. 2022

Comp Rev Food Sci Food Safe

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For health and safety concerns, traditional high-calorie sweeteners and artificial sweeteners are gradually replaced in food industries by natural and low-calorie sweeteners. As a natural and high-quality sugar substitute, steviol glycosides (SvGls) are continually scrutinized regarding their safety and application. Recently, the cultivation of organic stevia has been increasing in many parts of Europe and Asia, and it is obvious that there is a vast market for sugar substitutes in the future. Rebaudioside A, the main component of SvGls, is gradually accepted by consumers due to its safe, zero calories, clear, and sweet taste with no significant undesirable characteristics. Hence, it can be used in various foods or dietary supplements as a sweetener. In addition, rebaudioside A has been demonstrated to have many physiological functions, such as antihypertension, anti-diabetes, and anticaries. But so far, there are few comprehensive reviews of rebaudioside A. In this review article, we discuss the physicochemical properties, metabolic process, safety, regulatory, health benefits, and biosynthetic pathway of rebaudioside A and summarize the modification methods and state-of-the-art production and purification techniques of rebaudioside A. Furthermore, the current problems hindering the future production and application of rebaudioside A are analyzed, and suggestions are provided.

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“…It is cultivated in many parts of Brazil, China, Thailand, Paraguay, Central America, and India commercially and widely used in foods, beverages, medicine, cosmetics, and many other food industries (Stoyanova et al., 2011 ). Stevia is used for treating several kinds of noncommunicable diseases (NCDs) such as cancer, T2D, hypertension, kidney disease, obesity, dental caries, and oxidative stress and have also shown antimicrobial activity (Ahmad et al., 2020 ; Singh & Rao, 2005 ; Talevi, 2021 ). Some recent studies found that stevia consumption can help to main weight, energy intake, and appetite (Stamataki et al., 2020 ; Stamataki, Scott, et al., 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Effect of stevia leaves (Stevia rebaudiana Bertoni) on diabetes: A systematic review and meta‐analysis of preclinical studies

Chowdhury

Alam

Raihan

et al. 2022

Food Science & Nutrition

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Diabetes is a common metabolic disease resulting from insulin deficiency or insulin resistance at the cellular level. It is associated with several noncommunicable diseases (NCDs), such as dysfunction or failure of organs, like kidneys, heart, blood vessel, thus predisposed to hypertension, renal disease, ocular diseases, stroke, heart failure, obesity, etc. (Mellitus, 2005). Among other types of diabetes, it is estimated that around 90-95% of patients with diabetes are suffering from Type-2-diabetes (T2D) in the world (Issa & Hussen Bule, 2015).

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Potential medicinal effects and applications of stevia constituents

Cited by 13 publications

References 85 publications

Steviol Glycoside, L-Arginine, and Chromium(III) Supplementation Attenuates Abnormalities in Glucose Metabolism in Streptozotocin-Induced Mildly Diabetic Rats Fed a High-Fat Diet

Steviol Glycoside, L-Arginine, and Chromium(III) Supplementation Attenuates Abnormalities in Glucose Metabolism in Streptozotocin-Induced Mildly Diabetic Rats Fed a High-Fat Diet

Natural and low‐caloric rebaudioside A as a substitute for dietary sugars: A comprehensive review

Effect of stevia leaves (Stevia rebaudiana Bertoni) on diabetes: A systematic review and meta‐analysis of preclinical studies

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