Potential Myocardial Protection of 3,4‐seco‐Lupane Triterpenoids from Acanthopanax sessiliflorus Leaves

Abstract

A rich of 3,4-seco-lupane triterpenoids including chiisanoside (CSS), divaroside (DVS), sessiloside-A1 (SSA) and chiisanogenin (CSG) were isolated from the ethanol extract of the leaves of Acanthopanax sessiliflorus. On the basis of previous studies, this article focused on four important components of 3,4-seco-lupane triterpenoids in Acanthopanax sessiliflorus leaves and explored their protective effects against aconitine-induced cardiomyocyte injury and their molecular mechanisms. The results showed that pretreatment with 3,4-seco-lupane triterpenoids could effectively increase cell viability, reduce CK-MB and LDH activities, reduce ROS production, maintain calcium concentration balance, and inhibit apoptosis, with divaroside having the best effect. In addition, Western blot results showed that divaroside down-regulated Cleaved caspase-3 and Bax and up-regulated Bcl-2 expression through activating the PI3 K/AKT pathway. However, the LY294002 inhibitor reversed this situation. This suggests that 3,4-seco-lupane triterpenoids may be a new hotspot for potential myocardial protective drugs research.

Seco-Lupane Triterpene Derivatives Induce Ferroptosis through GPX4/ACSL4 Axis and Target Cyclin D1 to Block the Cell Cycle

“…Our group has been engaged in the research on chemical constituents and biological activities of A. sessiliflorus for many years and found that its leaves contain a large number of lupane triterpenes represented by chiisanoside, which display a variety of biological activities such as hepatoprotective, cardioprotective, and antitumor activities. Moreover, the seco -lupane triterpenes without the glycosyl group were significantly superior to those containing the glycosyl group in antitumor activity .…”

Isolation and purification of Eleutherococcus sessiliflorus (Rupr. & Maxim.) S. Y. Hu peptides and study of their antioxidant effects and mechanisms

“…It is a local traditional Chinese medicine in the Changbai Mountain area of Jilin Province, China, and its root bark, called Wuga bark, shows efficacy in delaying aging, dispersing wind-dampness, and tonifying the liver and kidneys in many ways ( Choi et al, 2021a ; Choi et al, 2021b ). Modern pharmacological studies have shown that the active constituents of E. sessiliflorus have a variety of pharmacological activities such as immunomodulation ( Kim et al, 2013 ) and treatment of cardiovascular diseases ( Wang et al, 2021 ) and are anti-inflammatory ( Kim et al, 2020 ), sedative ( Song et al, 2017 ), anti-tumor ( Thamizhiniyan et al, 2015 ), and antioxidant ( Chen et al, 2020 ). Therefore, E. sessi liflorus has prospects such as social value and economic benefits, both as a medicine and a healthcare functional food.…”

Phytochemistry and Pharmacology of Eleutherococcus sessiliflorus (Rupr. & Maxim.) S.Y.Hu: A Review

“…Since its approval as a new food resource by the Ministry of Health of the People’s Republic of China in 2008, E. sessiliflorus has become the foundation for a series of health products, such as tea, concentrated solutions, and wines, continuously entering the market. Modern pharmacological research has uncovered the remarkable properties of E. sessiliflorus , including its anti-inflammatory, antioxidant, antiplatelet aggregation, vasodilatory, cardioprotective, anti-aging, and anticancer effects [ 7 , 8 , 10 , 11 , 12 ]. Additionally, E. sessiliflorus can potentially improve glucose metabolism, cardiovascular function, and immune response.…”