Potential natural hydrosol blend TGLON suppresses the proliferation of five cancer cell lines and also ameliorates idiopathic pulmonary fibrosis in mouse model

Abstract

Background: Previous studies on natural substances for tumor cell inhibition have predominantly concentrated on efficacy, often overlooking safety concerns. This research utilizes "The Greatest Love of Nature (TGLON), a proprietary blend of plant hydrosols, to investigate its potential inhibitory effects on a variety of cancer cell lines while ensuring its relative safety to normal lung cells (MRC-5). Furthermore, initial animal studies have demonstrated that TGLON can mitigate the progression of idiopathic pulmonary fibrosis without acute oral toxicity, underscoring its potential utility as a nutritional supplement. Methods: TGLON, a hydrosol blend developed with specific proportions, underwent initial validation for its constituent composition and safety profile. The blend capacity to inhibit five different tumor cell types and alleviate pulmonary fibrosis was evaluated using cell viability assays and controlled animal experiments. Results: Dosages were determined to be safe at dilutions greater than 80-fold. At this concentration, TGLON exhibited inhibitory effects on 40.7% of lung cancer cells, 84% of liver cancer cells, 49.8% of breast cancer cells, 38% of stomach cancer cells, and inhibited 52% of leukemic lymphoblasts at a 200-fold dilution. Oral administration of TGLON was found to be safe and effective in reducing Bleomycin-induced pulmonary fibrosis in animal models. Conclusions:Under conditions deemed relatively safe, TGLON demonstrates bioactive properties, such as inhibiting five distinct types of human tumor cells and alleviating pulmonary fibrosis in animal models. These findings highlight its substantial potential as a nutritional supplement for improving overall patient health.