2022
DOI: 10.3389/fpain.2022.946846
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Potential Neuroimmune Interaction in Chronic Pain: A Review on Immune Cells in Peripheral and Central Sensitization

Abstract: Chronic pain is a long-standing unpleasant sensory and emotional feeling that has a tremendous impact on the physiological functions of the body, manifesting itself as a dysfunction of the nervous system, which can occur with peripheral and central sensitization. Many recent studies have shown that a variety of common immune cells in the immune system are involved in chronic pain by acting on the peripheral or central nervous system, especially in the autoimmune diseases. This article reviews the mechanisms of… Show more

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Cited by 26 publications
(17 citation statements)
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“…Neutrophils and macrophages are innate immune cells that can induce a transition from acute to chronic pain and maintain pain. Adaptive immune cells like B cells and T cells mainly initiate chronic pain, though T cells can also act to resolve pain 64 . This creates an interesting dichotomy in T cell regulation of pain.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Neutrophils and macrophages are innate immune cells that can induce a transition from acute to chronic pain and maintain pain. Adaptive immune cells like B cells and T cells mainly initiate chronic pain, though T cells can also act to resolve pain 64 . This creates an interesting dichotomy in T cell regulation of pain.…”
Section: Discussionmentioning
confidence: 99%
“…NK cells are traditionally viewed as pro-inflammatory, but they are also functionally important pain resolvers. B lymphocytes produce antibodies involved in humoral immunity and also present antigens 64 . Thus, temporal patterns of immune cell recruitment and activation confer distinct roles in regulating different types of pain.…”
Section: Discussionmentioning
confidence: 99%
“…Additionally, immune cells promote peripheral or central nervous system sensitization through proinflammatory molecules such as TNF-α. Mast cells and astrocytes release TNF-α affecting neuronal function and promoting the development of chronic pain (24,25). The effects of chronic inflammation and TNF-α, in particular, have been shown to lower levels of serotonin leading to depression (26).…”
Section: Discussionmentioning
confidence: 99%
“…Sensory nerves are related to neuro-inflammation. The persistence of chronic pelvic pain and its sensitization might also be responsible for recurrent conditions and prolonged pain in chronic prostatitis [ 6 7 8 ]. Research indicated that the autonomic nervous system regulates smooth muscles of the cardiovascular system and prostatic glandular secretion; therefore, the sympathetic and parasympathetic nerves are closely related to CP/CPPS [ 9 ].…”
Section: Introductionmentioning
confidence: 99%