Potential neuroprotective effects of hesperidin on 3-nitropropionic acid-induced neurotoxicity in rats

Menze, Esther T.; Tadros, Mariane G.; Abdel‐tawab, Ahmed M.; Khalifa, Amani E.

doi:10.1016/j.neuro.2012.07.007

Cited by 91 publications

(39 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…From the results, it was found that MDA levels were significantly increased in mitochondria isolated from 3-NPeexposed animals. A significant increase in MDA levels in the striatum of rats challenged with 3-NP has been reported earlier (Menze et al, 2012). Increased protein carbonyls can be formed by the reaction of proteins with aldehydes, like MDA (Denny Joseph and Muralidhara, 2013).…”

Section: Discussionmentioning

confidence: 71%

Mitochondrial modulators in experimental Huntington’s disease: reversal of mitochondrial dysfunctions and cognitive deficits

Mehrotra

Kanwal

Banerjee

et al. 2015

Neurobiology of Aging

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 71%

Mitochondrial modulators in experimental Huntington’s disease: reversal of mitochondrial dysfunctions and cognitive deficits

Mehrotra

Kanwal

Banerjee

et al. 2015

Neurobiology of Aging

View full text Add to dashboard Cite

“…For flavanones, animal and in vitro data also support cardio- and neuroprotective effects (3, 13, 42, 43, 52, 53). Flavanones and their metabolites improve endothelial function principally via improved blood flow, enhanced production or reduced NAD(P)H oxidase-dependent elimination of endothelial nitric oxide, and inhibited platelet function (14).…”

Section: Discussionmentioning

confidence: 87%

Habitual intake of anthocyanins and flavanones and risk of cardiovascular disease in men,

Cassidy

Bertoia

Chiuve

et al. 2016

The American Journal of Clinical Nutrition

193

133

View full text Add to dashboard Cite

Background: Although increased fruit intake reduces cardiovascular disease (CVD) risk, which fruits are most beneficial and what key constituents are responsible are unclear. Habitual intakes of flavonoids, specifically anthocyanins and flavanones, in which >90% of habitual intake is derived from fruit, are associated with decreased CVD risk in women, but associations in men are largely unknown.Objective: We examined the relation between habitual anthocyanin and flavanone intake and coronary artery disease and stroke in the Health Professionals Follow-Up Study.Design: We followed 43,880 healthy men who had no prior diagnosed CVD or cancer. Flavonoid intake was calculated with the use of validated food-frequency questionnaires.Results: During 24 y of follow-up, 4046 myocardial infarction (MI) and 1572 stroke cases were confirmed by medical records. Although higher anthocyanin intake was not associated with total or fatal MI risk, after multivariate adjustment an inverse association with nonfatal MI was observed (HR: 0.87; 95% CI: 0.75, 1.00; P = 0.04; P-trend = 0.098); this association was stronger in normotensive participants (HR: 0.81; 95% CI: 0.69, 0.96; P-interaction = 0.03). Anthocyanin intake was not associated with stroke risk. Although flavanone intake was not associated with MI or total stroke risk, higher intake was associated with a lower risk of ischemic stroke (HR: 0.78; 95% CI: 0.62, 0.97; P = 0.03, P-trend = 0.059), with the greatest magnitude in participants aged ≥65 y (P-interaction = 0.04).Conclusions: Higher intakes of fruit-based flavonoids were associated with a lower risk of nonfatal MI and ischemic stroke in men. Mechanistic studies and clinical trials are needed to unravel the differential benefits of anthocyanin- and flavanone-rich foods on cardiovascular health.

show abstract

“…Our previous data indicated that hesperidin increases neurogenesis by inducing differentiation of neural progenitors and supports neuronal survival in vitro (Nones et al, 2011). Whereas the neuroprotective property of hesperidin has been extensively investigated (Menze et al, 2012; Hong and An, 2015), its actions on synapses are less known. A screening of 65 flavonoids showed that hesperidin, among eight flavanones evaluated, was the only one able to increase the expression of synaptotagmin, but not PSD-95, in cortical neurons in vitro (Xu et al, 2013b).…”

Section: Discussionmentioning

confidence: 99%

Flavonoid Hesperidin Induces Synapse Formation and Improves Memory Performance through the Astrocytic TGF-β1

Matias

Diniz

Buosi

et al. 2017

Front. Aging Neurosci.

View full text Add to dashboard Cite

Synapse formation and function are critical events for the brain function and cognition. Astrocytes are active participants in the control of synapses during development and adulthood, but the mechanisms underlying astrocyte synaptogenic potential only began to be better understood recently. Currently, new drugs and molecules, including the flavonoids, have been studied as therapeutic alternatives for modulation of cognitive processes in physiological and pathological conditions. However, the cellular targets and mechanisms of actions of flavonoids remain poorly elucidated. In the present study, we investigated the effects of hesperidin on memory and its cellular and molecular targets in vivo and in vitro, by using a short-term protocol of treatment. The novel object recognition test (NOR) was used to evaluate memory performance of mice intraperitoneally treated with hesperidin 30 min before the training and again before the test phase. The direct effects of hesperidin on synapses and astrocytes were also investigated using in vitro approaches. Here, we described hesperidin as a new drug able to improve memory in healthy adult mice by two main mechanisms: directly, by inducing synapse formation and function between hippocampal and cortical neurons; and indirectly, by enhancing the synaptogenic ability of cortical astrocytes mainly due to increased secretion of transforming growth factor beta-1 (TGF-β1) by these cells. Our data reinforces the known neuroprotective effect of hesperidin and, by the first time, characterizes its synaptogenic action on the central nervous system (CNS), pointing astrocytes and TGF-β1 signaling as new cellular and molecular targets of hesperidin. Our work provides not only new data regarding flavonoid’s actions on the CNS but also shed light on possible new therapeutic alternative based on astrocyte biology.

show abstract

Potential neuroprotective effects of hesperidin on 3-nitropropionic acid-induced neurotoxicity in rats

Cited by 91 publications

References 39 publications

Mitochondrial modulators in experimental Huntington’s disease: reversal of mitochondrial dysfunctions and cognitive deficits

Mitochondrial modulators in experimental Huntington’s disease: reversal of mitochondrial dysfunctions and cognitive deficits

Habitual intake of anthocyanins and flavanones and risk of cardiovascular disease in men,

Flavonoid Hesperidin Induces Synapse Formation and Improves Memory Performance through the Astrocytic TGF-β1

Contact Info

Product

Resources

About