Potential neuroprotective effects of oxyresveratrol against traumatic injury

Modification of oral absorption of oxyresveratrol using lipid based nanoparticles

“…It has been reported to exhibit potent antioxidant/anti-inflammatory activities [1,2], inhibits tyrosinase enzyme [3], and has strong neuroprotective activities [4]. OXY has also been shown to possess antiviral activities against several types of herpes simplex virus (HSV-1 and HSV-2) [5,6], various varicella zoster virus (VZV) [7] as well as influenza virus [8].…”

Methodologies and limitations in the analysis of potential neuroprotective compounds derived from natural products

“…In these approaches, compounds are added to brain derived cells and challenged with toxic substances known to produce cell damage and death, such as glutamate or hydrogen peroxide, which will generate excessive ROS and/or RNS [12,13]. This approach can include immortalized cell lines [14], or primary cells, which are generally derived from embryonic or neonatal brains of mice or rats [15,16]. One of the major advantages of this approach is that compounds can be screened for protective activity over the course of a few weeks, compared to in vivo approaches, which can take months.…”

Effects of oxyresveratrol and its derivatives on cultured P19-derived neurons

“…Studies have shown that 1 could protect cultured neurons from β-amyloid-induced toxicity and defend neuroblastoma cells against 6-hydroxydopamine, suggesting potential applications for AD and PD, respectively [11,12]. The compound was also studied for protective effects against cerebral ischemia in vivo [13], and traumatic injury in vitro [14]. Its antioxidant activity has been investigated in several models [7,15,16].…”