Potential New Treatments for Knee OA: A Prospective Review of Registered Trials

Ioniţescu, Marius; Vermeşan, Dinu; Andor, Bogdan; Dumitrascu, Cristian; Al-Qatawneh, Musab; Bloanca, Vlad; Dumitraşcu, Andrei; Prejbeanu, Radu

doi:10.3390/app112211049

Cited by 3 publications

(2 citation statements)

References 42 publications

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“…An important technical detail in performing OWHTO is related to the stability of the osteotomy, in direct relation with the consolidation of the osteotomy gap, postoperative care, and patient's quality of life [38,39]. The stability of the osteotomy gap is related to the fixation implant design, geometry of the osteotomy, and correction of the mechanical axis of the limb [40][41][42][43][44].…”

Section: Discussionmentioning

confidence: 99%

Geometrical Planning of the Medial Opening Wedge High Tibial Osteotomy—An Experimental Approach

et al. 2022

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This article presents an experimental approach to the geometrical planning of the medial opening wedge high tibial osteotomy surgery which, as it is known, is an efficient surgical strategy quite widely used in treating knee osteoarthritis. While most of the published papers focus on analyzing this surgery from a medical point of view, we suggest a postoperative experimental evaluation of the intervention from a biomechanical point of view. The geometrical planning and, more specifically, the determination of the point of intersection between the corrected mechanical axis and the medial-lateral articular line of the knee, is a problem quite often debated in literature. This paper aims to experimentally investigate the behavior of the tibia with an open wedge osteotomy fixed with a locking plate, TomoFix (DE Puy Synthes), taking into account two positions of the mechanical axis of the leg on the width of the tibial plateau, measured from medial to lateral at 50% and 62.5% (Fujisawa point), respectively. The variations of the force relative to the deformation, strains, and displacements resulting from the progressive loading of the tibial plateau are studied. The research results reveal that using the Fujisawa point is better for conducting the correction not only for medical reasons, but also from a mechanical point of view.

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Section: Discussionmentioning

confidence: 99%

Geometrical Planning of the Medial Opening Wedge High Tibial Osteotomy—An Experimental Approach

et al. 2022

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“…Osteoarthritis results in inflammation with degeneration of surrounding joint cartilage and the underlying bone. Related symptoms of this degeneration include decreased range of motion, instability, chronic pain, and severe disability [5]. Knee osteoarthritis has been ranked the 11th highest contributor to global disability [6].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Efficacy of Cryopreserved Human Umbilical Cord Tissue Allograft for the Supplementation of Cartilage Defects Associated to Knee Osteoarthritis: An Observational Data Collection Study

Davis¹,

Martin²,

Sheinkop³

et al. 2022

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The primary objective of this study is to report the initial efficacy data observed with the use of cryopreserved human umbilical tissue allograft for the supplementation of cartilage defects in patients with symptomatic knee osteoarthritis. Our primary endpoints were pain, stiffness, and functional recovery scores. In this ongoing study, 55 participants (age 56-93 years) received a single Wharton's jelly tissue allograft application. The study dose consisted of 150mg of Wharton's jelly allograft suspended in approximately 2mL of sterile Sodium Chloride 0.9% solution (normal saline). Each study knee application was performed under ultrasound guidance in a physician's office. The research methodology consisted of NPRS scores and WOMAC subsection scores including pain, stiffness, and physical function. Study enrollment consisted of 55 patients followed for a post-application duration of 90 days. No adverse events or adverse reactions were reported. The results demonstrated statistically significant improvements of NPRS and WOMAC in initial versus 90-day examination. The data represents Wharton's jelly tissue allograft applications are a safe, non-surgical, and efficacious for patients with symptomatic articular cartilage defects associated with osteoarthritis of the knee.

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Evaluation of the Efficacy of Cryopreserved Human Umbilical Cord Tissue Allografts to Augment Functional and Pain Outcome Measures in Patients with Knee Osteoarthritis: An Observational Data Collection Study

2022

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The primary objective of this study is to report the initial efficacy data observed with the use of cryopreserved human umbilical tissue allografts for supplementation in patients with symptomatic degeneration of load-bearing articular cartilage in the knee joint. Our primary endpoints were pain, stiffness, and functional recovery scores. In this ongoing study, 55 participants (age 56–93 years) received a single Wharton’s jelly tissue allograft application. The study dose consisted of 150 mg of Wharton’s jelly allograft suspended in approximately 2 mL of sterile sodium chloride 0.9% solution (normal saline). Each study knee application was performed under ultrasound guidance in a physician’s office. The research methodology consisted of Numeric Pain Rating Scale (NPRS) scores and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) subsection scores including pain, stiffness, and physical function. Study enrollment consisted of 55 patients followed for a post-application duration of 90 days. No adverse events or adverse reactions were reported. The results demonstrated statistically significant improvements of NPRS and WOMAC in initial versus 90-day examination. The data represent Wharton’s jelly tissue allograft applications are safe, non-surgical, and efficacious for patients with symptomatic osteoarthritis of the knee.

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Potential New Treatments for Knee OA: A Prospective Review of Registered Trials

Cited by 3 publications

References 42 publications

Geometrical Planning of the Medial Opening Wedge High Tibial Osteotomy—An Experimental Approach

Geometrical Planning of the Medial Opening Wedge High Tibial Osteotomy—An Experimental Approach

Evaluation of the Efficacy of Cryopreserved Human Umbilical Cord Tissue Allograft for the Supplementation of Cartilage Defects Associated to Knee Osteoarthritis: An Observational Data Collection Study

Evaluation of the Efficacy of Cryopreserved Human Umbilical Cord Tissue Allografts to Augment Functional and Pain Outcome Measures in Patients with Knee Osteoarthritis: An Observational Data Collection Study

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