Potential occupational risks for neurodegenerative diseases

Park, Robert M.; Schulte, Paul A.; Bowman, Joseph D.; Walker, James T.; Bondy, Stephen C.; Yost, Michael G.; Touchstone, Jennifer; Dosemeci, Mustafa

doi:10.1002/ajim.20178

Cited by 194 publications

(206 citation statements)

References 86 publications

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“…OCCUPATIONAL EXPOSURES AND SYSTEMIC AUTOIMMUNE DISEASES (36)(37)(38). Because the job titles used for our analyses were defined as the decedents' "usual" rather than most recent occupations, we intended to capture occupational exposures that occurred prior to the onset of disease.…”

Section: Discussionmentioning

confidence: 99%

Systemic autoimmune disease mortality and occupational exposures

Gold¹,

Ward²,

Dosemeci³

et al. 2007

Arthritis & Rheumatism

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Objective. To generate hypotheses regarding occupational exposures that may cause systemic autoimmune diseases.Methods. Based on examination of US death certificates, we identified deaths in 26 states for which a cause was listed as rheumatoid arthritis (RA) (n ‫؍‬ 36,178), systemic lupus erythematosus (SLE) (n ‫؍‬ 7,241), systemic sclerosis (n ‫؍‬ 5,642), or other systemic autoimmune disease (n ‫؍‬ 4,270). Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated to estimate associations between occupation and death from any systemic autoimmune disease, and from RA, SLE, and systemic sclerosis, specifically. Additionally, we estimated risks associated with occupational exposures, which were assigned using job-exposure matrices.Results. A broad array of occupations was associated with death from systemic autoimmune diseases, including several of a priori interest. Farming occupation was associated with death from any systemic autoimmune disease (OR 1.3 [95% CI 1.2-1.4]), and increased risk was also seen with occupational exposure to animals and pesticides. Several industrial occupations were associated with death from any systemic autoimmune disease, including mining machine operators (OR 1.3 [95% CI 1.1-1.5]), miscellaneous textile machine operators (OR 1.2 [95% CI 1.0-1.4]), and hand painting, coating, and decorating occupations (OR 1.8 [95% CI 1.0-2.9]). These occupations were also significantly associated with death from the specific autoimmune diseases examined. Certain occupations entailing exposure to the public, such as teachers, were associated with systemic autoimmune disease-related death, whereas others, such as waiters and waitresses, were not.Conclusion. Our results suggest that death from systemic autoimmune diseases may be associated with occupational exposures encountered in farming and industry. The hypotheses generated in this study provide leads for future research on determinants of these diseases.

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Section: Discussionmentioning

confidence: 99%

Systemic autoimmune disease mortality and occupational exposures

Gold¹,

Ward²,

Dosemeci³

et al. 2007

Arthritis & Rheumatism

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“…Also, epidemiological data on populations occupationaly exposed to ELF fields have been interpreted as indicative of increased incidence of those cancers and other malignancies [see reviews by Ahlbom et al (3), Park et al (4) and Kheifets et al (5)]. On the basis of the epidemiological evidence, particularly on leukemia, the International Agency for Research on Cancer (IARC) has classified weak ELF MF as a 'possible carcinogenic' agent (class 2B).…”

Section: Introductionmentioning

confidence: 99%

Influence of a 50 Hz magnetic field and of all-trans‑retinol on the proliferation of human cancer cell lines

Trillo

2012

Int J Oncol

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Abstract. In vitro exposure to power frequency magnetic fields (MF) has been reported to influence cell proliferation and differentiation. However, the nature of the response of different human cancer cell types to these fields has not been sufficiently characterized. The present work investigates the response of two proliferating human cell lines of neuroblastoma (NB69) and hepatocarcinoma (HepG2) to a 42 h, intermittent treatment with a weak, 100 µT, 50 Hz MF, alone or in combination with 0.5 µM all-trans-retinol (ROL), a retinoid currently applied in oncostatic therapies. In each experimental replicate the cell samples were submitted to one of the following treatment combinations: MF+/ROL+, MF+/ ROL-, MF-/ROL+ or MF-/ROL-. The proliferative response was determined by cell counting (Trypan blue exclusion), BrdU incorporation and by spectrophotometric analysis of total protein and DNA content. The results show that when administered separately, the two treatments, MF and ROL, significantly enhanced cell proliferation in both cell lines. In NB69 simultaneous administration of MF and ROL induced an additive effect on cell proliferation, associated to increased DNA content. By contrast, in HepG2 the ROL-induced cell proliferation and increased protein content were partially blocked by simultaneous exposure to MF. Taken together, these data show that both agents, a weak MF and ROL at a low concentration, induce proliferative responses in the two assayed human cell lines. However, significant differences were observed between the responses of the two cellular species to the combined treatment with ROL and MF, indicating that the mechanisms underlying the cellular response to each of the two agents can mutually interact in a manner that is cell type-specific.

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“…This is the first study, to our knowledge, to investigate the risk for Parkinson's disease among gardeners. Several studies have found positive associations between farming and Parkinson's disease (12)(13)(14)(15)(16), including a Danish study, in which men working in agriculture and horticulture had a significantly higher risk for a first hospital admission for Parkinson's disease (SHR 132, 95% CI 111-156) than the general Danish population (17). It has been suggested that the increased risks of farmers Kenborg et al and agricultural workers are related to exposure to pesticide (17,18), and this hypothesis has been examined in several recent epidemiological studies, most of which found positive associations (18-27), while few were unable to find such effects (28)(29)(30).…”

Section: Discussionmentioning

confidence: 99%