Potential of Allylmercaptocaptopril as an
Anti Cataract Agent against Galactosemic
Cataract in Rats: An in Vitro and in Vivo Studies

Lakshmi, K. S.; Sharma, Swati

doi:10.29333/ejgm/82712

Cited by 3 publications

(4 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The underlying mechanisms in sugar-induced cataract are becoming unraveled. Galactose is reduced to galactitol by the aldose reductase and causes hydration of the eye which eventually leads to osmotic stress (Patterson and Bunting, 1965;Kinoshita, 1974;Lakshmi and Sharma, 2011), thereby causing enzyme inactivation (such as Na + K -ATPase), loss of membrane integrity, refractive index fluctuations and loss of protein functions (Kisic et al, 2012). These effects are further aggravated by increased hydration due to high concentration of protein in the lens (Patterson and Bunting, 1965).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Effect of Spathodea Campanulata Flower Bud Exudate on Cataractogenesis in Rat Lenses

Adio

Faluyi²,

Osoniyi³

2014

Afr J Tradit Complement Altern Med

View full text Add to dashboard Cite

Background: The flower bud exudates of Spathodea campanulata is commonly used as a local eye drop in Nigeria and is anecdotally claimed to improve vision. This study evaluated the anti-cataract activity of Spathodea campanulata (SPCM) flower bud exudates against cataractogenesis using rat lenses. This was done with a view to providing empirical scientific support for the use of the exudates from SPCM in the treatment and management of certain eye disorders. Materials and Methods: Fifty (50) rat lenses were used in this study, i.e. five groups of ten (10) lenses per group. Lenses were incubated in artificial aqueous humor (Normal control) with simultaneous incubation in 30 mM galactose (Untreated cataract). Co-incubation with captopril (Captopril treated cataract); 0.1 mg/ml of the exudate (Exudate treated cataract - Low dose) and 0.2 mg/ml of exudate (Exudate treated cataract- High dose) constituted the study groups. After 72 hr of incubation, lenses were observed for cataract and the preventive potential of the exudate against cataractogenesis was evaluated through the determination of the levels of anti-oxidant parameters such as total protein (TP), glutathione (GSH), malondialdehyde (MDA) and activities of superoxide dismutase (SOD) and catalase (CAT) were evaluated in the lens homogenates. Results: Photographic evaluation of the lenses showed the development of cataract in the untreated cataract group while opacification was retarded in higher dose exudate-treated and captopril treated lenses. Significant decrease in the levels of GSH and total protein, reduction in SOD and CAT activities as well as increase in MDA content were observed in cataractous lenses when compared with the normal control. SPCM displayed a dose-related anti-cataract activity. Captopril showed comparable anti-cataract potential to (0.2 mg/ml) SPCM. GSH, SOD and CAT activity in captopril treated cataract lenses increased to 75.55%, 64.08% and 72.45% of the normal control values respectively. In (0.2 mg/ml) exudate treated cataract lenses; GSH, SOD and CAT activity increased to 57.7%, 76.69% and 80.61% respectively. Conclusion: The study concluded that exudate of SPCM elicited its anti-cataract potential through its anti-oxidant activities.

show abstract

Section: Discussionmentioning

confidence: 99%

Evaluation of the Effect of Spathodea Campanulata Flower Bud Exudate on Cataractogenesis in Rat Lenses

Adio

Faluyi²,

Osoniyi³

2014

Afr J Tradit Complement Altern Med

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Evaluation of the effect of <i>Spathodea campanulata</i> flower bud exudate on cataractogenesis in rat lenses

Gbemisola¹,

Faluyi²,

Osoniyi³

2015

Afr. J. Trad. Compl. Alt. Med.

View full text Add to dashboard Cite

Background: The flower bud exudates of Spathodea campanulata is commonly used as a local eye drop in Nigeria and is anecdotally claimed to improve vision. This study evaluated the anti-cataract activity of Spathodea campanulata (SPCM) flower bud exudates against cataractogenesis using rat lenses. This was done with a view to providing empirical scientific support for the use of the exudates from SPCM in the treatment and management of certain eye disorders. Materials and Methods: Fifty (50) rat lenses were used in this study, i.e. five groups of ten (10) lenses per group. Lenses were incubated in artificial aqueous humor (Normal control) with simultaneous incubation in 30 mM galactose (Untreated cataract). Co-incubation with captopril (Captopril treated cataract); 0.1 mg/ml of the exudate (Exudate treated cataract -Low dose) and 0.2 mg/ml of exudate (Exudate treated cataract-High dose) constituted the study groups. After 72 hr of incubation, lenses were observed for cataract and the preventive potential of the exudate against cataractogenesis was evaluated through the determination of the levels of anti-oxidant parameters such as total protein (TP), glutathione (GSH), malondialdehyde (MDA) and activities of superoxide dismutase (SOD) and catalase (CAT) were evaluated in the lens homogenates. Results: Photographic evaluation of the lenses showed the development of cataract in the untreated cataract group while opacification was retarded in higher dose exudate-treated and captopril treated lenses. Significant decrease in the levels of GSH and total protein, reduction in SOD and CAT activities as well as increase in MDA content were observed in cataractous lenses when compared with the normal control. SPCM displayed a doserelated anti-cataract activity. Captopril showed comparable anti-cataract potential to (0.2 mg/ml) SPCM. GSH, SOD and CAT activity in captopril treated cataract lenses increased to 75.55%, 64.08% and 72.45% of the normal control values respectively. In (0.2 mg/ml) exudate treated cataract lenses; GSH, SOD and CAT activity increased to 57.7%, 76.69% and 80.61% respectively. Conclusion:The study concluded that exudate of SPCM elicited its anti-cataract potential through its anti-oxidant activities.

show abstract

“…Cataract is one of the main reasons for the cause of blindness worldwide. Due to cataract, approximately 19 billion people are visionless in the world (1). It leads to opacification of the eye lens and impairs vision.…”

Section: Introductionmentioning

confidence: 99%

“…Alteration in some biochemical processes such as oxidative stress, altered epithelial metabolism, phase transition, calpain-induced proteolysis, calcium accumulation, and cytoskeletal loss are related to the development of cataract (2). Though the cause of cataract is not fully understood, the major mechanism involved in the development of cataract is oxidative damage to the constituents of the eye lens (1). Cataract is accompanied by alterations in antioxidant system such as catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx) and reduced glutathione (GSH) (3).…”

Section: Introductionmentioning

confidence: 99%

Isolation, characterisation and in vitro screening of anticataract potential of Fucoidan from Sargassum wightii Greville

Ramu¹,

Mahendra²,

Kunchakuri³

et al. 2018

J Herbmed Pharmacol

View full text Add to dashboard Cite

show abstract

Potential of Allylmercaptocaptopril as an Anti Cataract Agent against Galactosemic Cataract in Rats: An in Vitro and in Vivo Studies

Abstract: Aim: Allylmercaptocaptopril (AMC) is a covalently bonded product of allicin and captopril has been evaluated for its anticataract activity

Cited by 3 publications

References 32 publications

Evaluation of the Effect of Spathodea Campanulata Flower Bud Exudate on Cataractogenesis in Rat Lenses

Evaluation of the Effect of Spathodea Campanulata Flower Bud Exudate on Cataractogenesis in Rat Lenses

Evaluation of the effect of <i>Spathodea campanulata</i> flower bud exudate on cataractogenesis in rat lenses

Isolation, characterisation and in vitro screening of anticataract potential of Fucoidan from Sargassum wightii Greville

Contact Info

Product

Resources

About