Potential of Caffeine in Alzheimer’s Disease—A Review of Experimental Studies

Londzin, Piotr; Zamora, Milena; Kąkol, Beata; Taborek, Aleksandra; Folwarczna, Joanna

doi:10.3390/nu13020537

Cited by 55 publications

(45 citation statements)

References 200 publications

(463 reference statements)

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“…This is only partly unexpected, as their protective effects, such as that on survival, though observed in adults have not been demonstrated for the older population ( 43 ). On the other hand, another positive effect of caffeine, such as on cognitive functions, does not translate into an unequivocal benefit from habitual intake in older people ( 44 , 45 ), probably because of the well-known tolerance effect that reduces the systemic impact of caffeine ( 46 ). Ultimately, no studies have analyzed the independent influence of coffee/tea consumption on frailty, but only “patterns” in which tea and coffee are components that contribute to the pattern score ( 47–49 ).…”

Section: Discussionmentioning

confidence: 99%

Plasmatic Hippuric Acid as a Hallmark of Frailty in an Italian Cohort: The Mediation Effect of Fruit–Vegetable Intake

Brunelli

Davin

Sestito

et al. 2021

The Journals of Gerontology: Series A

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Frailty syndrome is an age-related condition involving a loss of resilience, susceptibility to adverse health outcomes, and poor quality of life. This study was conducted in the framework of InveCe.Ab, an ongoing longitudinal population-based study. Plasma from 130 older individuals (older adults aged 76–78 years) was analyzed and validated (on 303 participants) using mass spectrometry-based metabolomics approaches. Equivalence tests showed that metabolites from the central cellular metabolic pathways were equivalent in frail and fit participants. Hippuric acid was the only cometabolite that distinguished fit from frail older adults. Logistic regression analysis indicated that high hippuric acid levels are significantly associated with a reduction of the risk of frailty after 4 years. Mediation analysis using a Frailty Index, hippuric acid, and fruit–vegetable intake supported the role of fruit–vegetable consumption in the hippuric acid relationship with the Frailty Index. These data point to low plasma hippuric acid as a plausible hallmark of frailty status, associated with lower fruit–vegetable intakes.

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Section: Discussionmentioning

confidence: 99%

Plasmatic Hippuric Acid as a Hallmark of Frailty in an Italian Cohort: The Mediation Effect of Fruit–Vegetable Intake

Brunelli

Davin

Sestito

et al. 2021

The Journals of Gerontology: Series A

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“…Concerning aspects relating to lifestyle, multiple studies have examined the potential role of phytochemicals in preventing and slowing down progressive pathogenic changes in AD, including flavonoids, phenolic acids, carotenoids, curcumin, resveratrol, and some alkaloids (in the comprehensive reviews [ 10 , 11 ]). Among them, the effects of caffeine seem to be well researched and documented [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

The Neuroprotective Effects of Moderate and Regular Caffeine Consumption in Alzheimer’s Disease

Zhou

Lin

2021

Oxidative Medicine and Cellular Longevity

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The increasing numbers of elderly Alzheimer’s disease (AD) patients because of a steady increase in the average lifespan and aging society attract great scientific concerns, while there were fewer effective treatments on AD progression due to unclear exact causes and pathogenesis of AD. Moderate (200-500 mg/d) and regular caffeine consumption from coffee and tea are considered to alleviate the risk of AD and have therapeutic potential. This paper reviewed epidemiological studies about the relationship of caffeine intake from coffee or/and tea with the risk of AD and summarized the caffeine-related AD therapies based on experimental models. And further well-designed and well-conducted studies are suggested to investigate the optimal dosages, frequencies, and durations of caffeine consumption to slow down AD progression and treat AD.

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“…The efficacy of caffeine (AR antagonist) against AD and AD-related cognitive impairment was reviewed, focusing on the proposed protective mechanisms of action [ 79 ]. There is evidence that caffeine and A 2A R antagonists afford protection against Aβ-induced amnesia in vivo [ 80 ] and prevent the neuronal cell death caused by exposure of rat cultured cerebellar granule neurons to 25 µM Aβ 25-35 for 48 h [ 81 ].…”

Section: Discussionmentioning

confidence: 99%

Early Effects of the Soluble Amyloid β25-35 Peptide in Rat Cortical Neurons: Modulation of Signal Transduction Mediated by Adenosine and Group I Metabotropic Glutamate Receptors

Castillo

Ballesteros-Yáñez

León-Navarro

et al. 2021

IJMS

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The amyloid β peptide (Aβ) is a central player in the neuropathology of Alzheimer’s disease (AD). The alteration of Aβ homeostasis may impact the fine-tuning of cell signaling from the very beginning of the disease, when amyloid plaque is not deposited yet. For this reason, primary culture of rat cortical neurons was exposed to Aβ25-35, a non-oligomerizable form of Aβ. Cell viability, metabotropic glutamate receptors (mGluR) and adenosine receptors (AR) expression and signalling were assessed. Aβ25-35 increased mGluR density and affinity, mainly due to a higher gene expression and protein presence of Group I mGluR (mGluR1 and mGluR5) in the membrane of cortical neurons. Intriguingly, the main effector of group I mGluR, the phospholipase C β1 isoform, was less responsive. Also, the inhibitory action of group II and group III mGluR on adenylate cyclase (AC) activity was unaltered or increased, respectively. Interestingly, pre-treatment of cortical neurons with an antagonist of group I mGluR reduced the Aβ25-35-induced cell death. Besides, Aβ25-35 increased the density of A1R and A2AR, along with an increase in their gene expression. However, while A1R-mediated AC inhibition was increased, the A2AR-mediated stimulation of AC remained unchanged. Therefore, one of the early events that takes place after Aβ25-35 exposure is the up-regulation of adenosine A1R, A2AR, and group I mGluR, and the different impacts on their corresponding signaling pathways. These results emphasize the importance of deciphering the early events and the possible involvement of metabotropic glutamate and adenosine receptors in AD physiopathology.

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Potential of Caffeine in Alzheimer’s Disease—A Review of Experimental Studies

Cited by 55 publications

References 200 publications

Plasmatic Hippuric Acid as a Hallmark of Frailty in an Italian Cohort: The Mediation Effect of Fruit–Vegetable Intake

Plasmatic Hippuric Acid as a Hallmark of Frailty in an Italian Cohort: The Mediation Effect of Fruit–Vegetable Intake

The Neuroprotective Effects of Moderate and Regular Caffeine Consumption in Alzheimer’s Disease

Early Effects of the Soluble Amyloid β25-35 Peptide in Rat Cortical Neurons: Modulation of Signal Transduction Mediated by Adenosine and Group I Metabotropic Glutamate Receptors

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