Potential of curcumin-loaded cubosomes for topical treatment of cervical cancer

Victorelli, Francesca Damiani; Manni, Livia Salvati; Biffi, Stefania; Bortot, Barbara; Buzzá, Hilde Harb; Lutz‐Bueno, Viviane; Handschin, Stephan; Calixto, Giovana Maria Fioramonti; Murgia, Sergio; Chorilli, Marlus; Mezzenga, Raffaele

doi:10.1016/j.jcis.2022.04.031

Cited by 41 publications

(28 citation statements)

References 83 publications

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“…In turn, Victorelli et al developed mucoadhesive cubosomes for the delivery of curcumin for cervical cancer treatment and used DLS to characterize the system. The curcumin-loaded cubosomes exhibited a homogeneous size distribution with a polydispersity index lower than 0.4 [96].…”

Section: Indirect Techniques Dynamic Light Scattering (Dls) and Zeta(...mentioning

confidence: 99%

“…For pharmaceutical applications, ζ-potential is crucial to determine the existence of cationic or anionic particles in solution. For instance, Victorelli et al was able to confirm the presence of positive charges on curcumin-loaded cubosomes through ζ-potential measurements [96]. Patil et al developed an inhalable bedaquiline-loaded cubosome nanocarriers for non-small cell lung cancer treatment.…”

Section: Indirect Techniques Dynamic Light Scattering (Dls) and Zeta(...mentioning

confidence: 99%

“…Several studies have been published regarding the application of cubosomes as a nanocarrier for cancer therapeutics. Doxorubicin [76], cisplatin [91], paclitaxel [91,134], curcumin [96], and quercetin [135] are a few examples of molecules that have been successfully encapsulated in cubosomes, either alone or in some kind of simultaneous encapsulation.…”

Section: Cancer Therapymentioning

confidence: 99%

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A Versatile Nanocarrier—Cubosomes, Characterization, and Applications

et al. 2022

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The impact of nanotechnology on the exponential growth of several research areas, particularly nanomedicine, is undeniable. The ability to deliver active molecules to the desired site could significantly improve the efficiency of medical treatments. One of the nanocarriers developed which has drawn researchers’ attention are cubosomes, which are nanosized dispersions of lipid bicontinuous cubic phases in water, consisting of a lipidic interior and aqueous domains folded in a cubic lattice. They stand out due to their ability to incorporate hydrophobic, hydrophilic, and amphiphilic compounds, their tortuous internal configuration that provides a sustained release, and the capacity to protect and safely deliver molecules. Several approaches can be taken to prepare this structure, as well as different lipids like monoolein or phytantriol. This review paper describes the different methods to prepare nanocarriers. As it is known, the physicochemical properties of nanocarriers are very important, as they influence their pharmacokinetics and their ability to incorporate and deliver active molecules. Therefore, an extensive characterization is essential to obtain the desired effect. As a result, we have extensively described the most common techniques to characterize cubosomes, particularly nanocarriers. The exceptional properties of the cubosomes make them suitable to be used in several applications in the biomedical field, from cancer therapeutics to imaging, which will be described. Taking in consideration the outstanding properties of cubosomes, their application in several research fields is envisaged.

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Section: Indirect Techniques Dynamic Light Scattering (Dls) and Zeta(...mentioning

confidence: 99%

Section: Indirect Techniques Dynamic Light Scattering (Dls) and Zeta(...mentioning

confidence: 99%

Section: Cancer Therapymentioning

confidence: 99%

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A Versatile Nanocarrier—Cubosomes, Characterization, and Applications

et al. 2022

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“…These characteristics are due to the high surface area between the hydrophilic and hydrophobic regions present in its structure. They are composed of a lipid and surfactant/stabilizer, which extends in three dimensions and two nanochannels interwoven, but not connected [ 291 , 292 , 293 ].…”

Section: Other Systems For Voriconazole Deliverymentioning

confidence: 99%

Nanotechnology-Based Approaches for Voriconazole Delivery Applied to Invasive Fungal Infections

et al. 2023

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Invasive fungal infections increase mortality and morbidity rates worldwide. The treatment of these infections is still limited due to the low bioavailability and toxicity, requiring therapeutic monitoring, especially in the most severe cases. Voriconazole is an azole widely used to treat invasive aspergillosis, other hyaline molds, many dematiaceous molds, Candida spp., including those resistant to fluconazole, and for infections caused by endemic mycoses, in addition to those that occur in the central nervous system. However, despite its broad activity, using voriconazole has limitations related to its non-linear pharmacokinetics, leading to supratherapeutic doses and increased toxicity according to individual polymorphisms during its metabolism. In this sense, nanotechnology-based drug delivery systems have successfully improved the physicochemical and biological aspects of different classes of drugs, including antifungals. In this review, we highlighted recent work that has applied nanotechnology to deliver voriconazole. These systems allowed increased permeation and deposition of voriconazole in target tissues from a controlled and sustained release in different routes of administration such as ocular, pulmonary, oral, topical, and parenteral. Thus, nanotechnology application aiming to delivery voriconazole becomes a more effective and safer therapeutic alternative in the treatment of fungal infections.

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“…Lyotropic nonlamellar liquid crystalline (LLC) nanoparticles are attracting increasing interest as alternative vehicles to conventional drug carriers (e.g., emulsions, liposomes, and solid lipid nanoparticles) for developing nanomedicines. − LLC nanoparticles are typically produced from biologically relevant amphiphilic lipids (including single unsaturated monoglycerides and their combinations with unsaturated fatty acids) and show a diverse range of internal structural features. − ,− Among this family of nanoparticles, also known as ISAsomes ( Internally Self-Assembled somes ), cubosomes and hexosomes with unique nanostructures are the most investigated vehicles (inverse bicontinuous cubic (Q 2 ) and discontinuous hexagonal (H 2 ) phases, respectively). ,, These nano-self-assemblies can efficiently encapsulate various bioactive compounds (including drugs, peptides, and nucleic acids). ,,− …”

Section: Introductionmentioning

confidence: 99%

PEGylation of Phosphatidylglycerol/Docosahexaenoic Acid Hexosomes with d-α-Tocopheryl Succinate Poly(ethylene glycol)₂₀₀₀ Induces Morphological Transformation into Vesicles with Prolonged Circulation Times

Bor

Lin

et al. 2022

ACS Appl. Mater. Interfaces

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Considering the broad therapeutic potential of omega-3 polyunsaturated fatty acids such as docosahexaenoic acid (DHA), here we study the effect of PEGylation of DHAincorporated hexosomes on their physicochemical characteristics and biodistribution following intravenous injection into mice. Hexosomes were formed from phosphatidylglycerol and DHA with a weight ratio of 3:2. PEGylation was achieved through the incorporation of either D-α-tocopheryl succinate poly(ethylene glycol) 2000 (TPGS-mPEG 2000 ) or 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-methoxy-poly(ethylene glycol) 2000 (DSPE-mPEG 2000 ) at a concentration of 1.5 wt %. Nanoparticle tracking analysis, synchrotron small-angle scattering, and cryo-transmission electron microscopy were employed to characterize the nanodispersions. The results show that PEGylated lipids induce a structural transition from an inverse hexagonal (H 2 ) phase inside the nanoparticles (hexosomes) to a lamellar (L α ) phase (vesicles). We also followed the effect of mouse plasma on the nanodispersion size distribution, number, and morphology because changes brought by plasma constituents could regulate the in vivo performance of intravenously injected nanodispersions. For comparative biodistribution studies, fluorescently labeled nanodispersions of equivalent quantum yields were injected intravenously into healthy mice. TPGS-mPEG 2000 -induced vesicles were most effective in avoiding hepatosplenic clearance at early time points. In an orthotopic xenograft murine model of glioblastoma, TPGS-mPEG 2000 -induced vesicles also showed improved localization to the brain compared with native hexosomes. We discuss these observations and their implications for the future design of injectable lyotropic nonlamellar liquid crystalline drug delivery nanosystems for therapeutic interventions of brain and liver diseases.

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Potential of curcumin-loaded cubosomes for topical treatment of cervical cancer

Cited by 41 publications

References 83 publications

A Versatile Nanocarrier—Cubosomes, Characterization, and Applications

A Versatile Nanocarrier—Cubosomes, Characterization, and Applications

Nanotechnology-Based Approaches for Voriconazole Delivery Applied to Invasive Fungal Infections

PEGylation of Phosphatidylglycerol/Docosahexaenoic Acid Hexosomes with d-α-Tocopheryl Succinate Poly(ethylene glycol)₂₀₀₀ Induces Morphological Transformation into Vesicles with Prolonged Circulation Times

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Potential of curcumin-loaded cubosomes for topical treatment of cervical cancer

Cited by 41 publications

References 83 publications

A Versatile Nanocarrier—Cubosomes, Characterization, and Applications

A Versatile Nanocarrier—Cubosomes, Characterization, and Applications

Nanotechnology-Based Approaches for Voriconazole Delivery Applied to Invasive Fungal Infections

PEGylation of Phosphatidylglycerol/Docosahexaenoic Acid Hexosomes with d-α-Tocopheryl Succinate Poly(ethylene glycol)2000 Induces Morphological Transformation into Vesicles with Prolonged Circulation Times

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PEGylation of Phosphatidylglycerol/Docosahexaenoic Acid Hexosomes with d-α-Tocopheryl Succinate Poly(ethylene glycol)₂₀₀₀ Induces Morphological Transformation into Vesicles with Prolonged Circulation Times