Two-dimensional (2D) layered MXene nanosheets have attracted extensive attention in tribology because of their unique physicochemical properties and excellent mechanical properties. However, MXenes suffer from problems, such as poor dispersion stability in oil, adhesion to the solid coating, and interfacial compatibility with polymer. Constructing heterostructures comprised of MXenes is an effective strategy to solve these problems. Moreover, each component of the heterostructures could play a synergistic role in enhancing the tribological properties. Based on the analysis of the key properties of MXenes, this paper designs MXene-based heterostructures and outlines the tribological applications and lubrication mechanisms of different forms of heterostructures. Finally, the existing research results are summarized, and future research directions are proposed, laying a foundation for the tribological applications of high-performance materials.