Potential of Forsythoside I as a therapeutic approach for acute lung injury: Involvement of TXNIP/NLRP3 inflammasome

Liang, Hongwen; Li, Kai; Zhuang, Zhe; Sun, Hong; Sun, Bo; Jiao, Minna; Cai, Yeqian; Cai, Guofeng

doi:10.1016/j.molimm.2021.03.004

Cited by 10 publications

(3 citation statements)

References 27 publications

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“…Lung tissue samples were fixed with 10% formalin and then embedded in paraffin. Next, tissues were cut into 5-µm-thick slices and stained with hematoxylin and eosin (H&E) according to the standard method [34]. After that, slices were dehydrated, sealed with a neutral gel, and observed by an optical light microscope (OLYMPUS IX51, Tokyo, Japan).…”

Section: Methodsmentioning

confidence: 99%

6-Gingerol attenuates sepsis-induced acute lung injury by suppressing NLRP3 inflammasome through Nrf2 activation

Pan

Liu

Wan

2023

Folia Histochem Cytobiol.

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Section: Methodsmentioning

confidence: 99%

6-Gingerol attenuates sepsis-induced acute lung injury by suppressing NLRP3 inflammasome through Nrf2 activation

Pan

Liu

Wan

2023

Folia Histochem Cytobiol.

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“…In addition to the above-mentioned ones, a series of other small-molecule compounds from dietary plants, such as Hederasaponin C from Pulsatilla chinensis (Bunge) Regel, Fe-Curcumin-based nanoparticles with original curcumin that extracted from Rhizoma curcumae longae, 5-Hydroxymethylfurfural (5-HMF) from Codonopsis pilosula , Syringaresinol from Sargentodoxa cuneata , Chrysosplenol D from Chrysanthemum morifolium Ramat, physalin B from Physalis alkekengi L, baicalin from Scutellaria baicalensis George, etc., exert certain protective effect on ARDS induced by sepsis through a mechanism directly targeting the NLRP3/caspase-1/GSDMD axis, as shown in Table . The employed animal models were septic murine established by either LPS challenge or CLP procedure, and the involved common signaling pathways include TLR4/NF-κB, ,− ,− TXNIP, sirt1/CCL4, PI3K/Akt, Nrf2/HO-1, , TRAF6/HSP90 and MAPK ,, aside from the NLRP3/caspase-1/GSDMD axis. By analyzing the chemical structure of the above small-molecule compounds, we found that the top three categories of naturally derived compounds with ameliorative effect on sepsis-induced ARDs by rescuing pyroptotic cell death in pulmonary cells are respectively flavonoids and flavone (7 candidates), terpenoids (5 candidates), and polyphenol and phenolic acids (5 candidates), as illustrated in Figures and .…”

Section: Small-molecule Compounds From Dietary Plants Alleviate Sepsi...mentioning

confidence: 99%

Sepsis-Induced Acute Lung Injury Is Alleviated by Small Molecules from Dietary Plants via Pyroptosis Modulation

Lan

et al. 2023

J. Agric. Food Chem.

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Sepsis-induced acute respiratory distress syndrome (ARDS) has high morbidity and mortality, and it has three major pathogeneses, namely alveolar–capillary barrier destruction, elevated gut permeability, and reduced neutrophil extracellular traps (NETS), all of which are pyroptosis-involved. Due to limitations of current agents like adverse reaction superposition, inevitable drug resistance, and relatively heavier financial burden, naturally extracted small-molecule compounds have a broad market even though chemically modified drugs have straightforward efficacy. Despite increased understanding of the molecular biology and mechanism underlying sepsis-induced ARDS, there are no specific reviews concerning how small molecules from dietary plants alleviate sepsis-induced acute lung injury (ALI) via regulating pyroptotic cell death. Herein, we traced and reviewed the molecular underpinnings of sepsis-induced ALI with a focus on small-molecule compounds from dietary plants, the top three categories of which are respectively flavonoids and flavone, terpenoids, and polyphenol and phenolic acids, and how they rescued septic ALI by restraining pyroptosis.

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“…Moreover, an in vitro antiviral test on Vero E6 cell lines confirmed the nontoxicity of these three forsythoside isomers and showed the difference in antiviral effects between them. 27 In addition, some other studies showed the different inflammatory-level regulation effects of For-I 28 and the antioxidant activity of several forsythoside isomers. 29 It could be seen that the forsythoside isomers may have different molecule characteristics and activities in many fields.…”

mentioning

confidence: 96%

A strategy of combining energy‐resolved mass spectrometry and density functional theory for the recognition of forsythoside isomers

Lin,

Sun,

Kuang

et al. 2024

Rapid Comm Mass Spectrometry

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RationaleIsomerism is very common in nature, and the mass spectrometry (MS) behavior of isomers is highly similar, making their spectral analysis and identification difficult. Computational chemistry can effectively assist the study of MS spectra and molecule structures. Herein, three isomers of forsythoside (For‐A, For‐H, and For‐I) were successfully identified using energy‐resolved MS combined with density functional theory (DFT).MethodsThe MS scan spectra of the isomers were collected in electrospray ionization MS. The possible positive/negative ion adduct sites were investigated using the DFT method, and the molecular formation energy of each precursor ion was obtained. In the multireaction monitoring mode, the spectra of the common precursor ion → product ion pair of the three isomers were acquired under different collision energy, and the optimal collision energy (OCE) and maximum relative intensity (MRI) of each product ion were obtained. The energy of the broken chemical bond was calculated.ResultsThe experimental data showed that the product ions of [M + H]+ of the three isomers have the greatest differences in OCE and MRI and were the most suitable to distinguish the three isomers. The DFT data showed that there was a good positive correlation between the bond fragmentation energy calculated by the quasi‐molecular ion model and OCE. The results indicated that the energy of precursor ions and corresponding fragments could be correlated with their experimental spectra.ConclusionsA strategy of combining energy‐resolved MS and DFT was implemented on the recognition of forsythoside isomers, and this strategy was expected to be applied to the identification of more isomers.

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Potential of Forsythoside I as a therapeutic approach for acute lung injury: Involvement of TXNIP/NLRP3 inflammasome

Cited by 10 publications

References 27 publications

6-Gingerol attenuates sepsis-induced acute lung injury by suppressing NLRP3 inflammasome through Nrf2 activation

6-Gingerol attenuates sepsis-induced acute lung injury by suppressing NLRP3 inflammasome through Nrf2 activation

Sepsis-Induced Acute Lung Injury Is Alleviated by Small Molecules from Dietary Plants via Pyroptosis Modulation

A strategy of combining energy‐resolved mass spectrometry and density functional theory for the recognition of forsythoside isomers

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