Potential of ginsenoside Rh2and its derivatives as anti-cancer agents

Li, Keke; Li, Zhongyu; Men, Lei; Li, Wei; Gong, Xia

doi:10.1016/s1875-5364(22)60193-6

Cited by 4 publications

(3 citation statements)

References 142 publications

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“…In 1.5 Y_vs_3.5 Y, probiotics Limosilactobacillus and Weissella ( Giraffa et al, 2010 ; Piccioni et al, 2021 ; Teixeira et al, 2021 ) were found to be significantly positively correlated with cholesteryl glucoside, which has a protective effect in gastric inflammation ( Kunimoto et al, 2003 ), the content in youth is higher than that in adulthood. In 3.5 Y_vs_6 Y, Streptococcus ( Mohammadi and Dhanashree, 2012 ) associated with lung disease was found to be significantly positively correlated with ginsenoside Rh5, which is an important bioactive compound and plays an important role in the occurrence of disease treatment ( Dou et al, 2001 ; Li et al, 2022 ). It is increased in old Tibetan sheep and may play a role in disease prevention and treatment in old age.…”

Section: Discussionmentioning

confidence: 99%

Multi-omics revealed rumen microbiota metabolism and host immune regulation in Tibetan sheep of different ages

Sha,

Liu,

et al. 2024

Front. Microbiol.

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The rumen microbiota and metabolites play an important role in energy metabolism and immune regulation of the host. However, the regulatory mechanism of rumen microbiota and metabolite interactions with host on Tibetan sheep’s plateau adaptability is still unclear. We analyzed the ruminal microbiome and metabolome, host transcriptome and serum metabolome characteristics of Tibetan sheep at different ages. Biomarkers Butyrivibrio, Lachnospiraceae_XPB1014_group, Prevotella, and Rikenellaceae_RC9_gut_group were found in 4 months, 1.5 years, 3.5 years, and 6 years Tibetan sheep, respectively. The rumen microbial metabolites were mainly enriched in galactose metabolism, unsaturated fatty acid biosynthesis and fatty acid degradation pathways, and had significant correlation with microbiota. These metabolites further interact with mRNA, and are co-enriched in arginine and proline metabolism, metabolism of xenobiotics by cytochrome P450, propanoate metabolism, starch and sucrose metabolism, gap junction pathway. Meanwhile, serum metabolites also have a similar function, such as chemical carcinogenesis − reactive oxygen species, limonene and pinene degradation, and cutin, suberine and wax biosynthesis, thus participating in the regulation of the body’s immune and energy-related metabolic processes. This study systematically revealed that rumen microbiota, metabolites, mRNA and serum metabolites of Tibetan sheep were involved in the regulation of fermentation metabolic function and immune level of Tibetan sheep at different ages, which provided a new perspective for plateau adaptability research of Tibetan sheep at different ages.

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Section: Discussionmentioning

confidence: 99%

Multi-omics revealed rumen microbiota metabolism and host immune regulation in Tibetan sheep of different ages

Sha,

Liu,

et al. 2024

Front. Microbiol.

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“…Alkylating agents such as cyclophosphamide are more potent in killing M and G1-phase cells, but are less selective and also strongly toxic to normal cells ( ABULFADL et al, 2023 ). Antimetabolites such as antifolates, antipurines, antipyrimidines, and cytarabine (Ara-C) are sensitive to S-phase cells and also function on G1-and G2-phase cells ( AMARO-HOSEY et al, 2021 ; LI et al, 2022 ). Antitumor antibiotics such as zorubicin and doxorubicin (adriamycin) (ADM) form complexes with DNA and RNA and inhibit cell division ( SKINNER et al, 1993 ).…”

Section: Critical Pediatric Antitumor Drugsmentioning

confidence: 99%

Anticancer therapy-induced adverse drug reactions in children and preventive and control measures

Yan,

Wang,

Yang

et al. 2024

Front. Pharmacol.

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In recent years, considerable achievements have been made in pediatric oncology with the innovation and development of antitumor drugs. However, compared to adults, children as a special group have not yet matured fully in terms of liver and kidney function. Moreover, pediatric patients are prone to more adverse drug reactions (ADRs) from the accumulation of antineoplastic drugs due to their smaller body size and larger body surface area. Chemotherapy-related ADRs have become a non-negligible factor that affects cancer remission. To date, studies on ADRs in pediatric cancer patients have emerged internationally, but few systematic summaries are available. Here, we reviewed the various systemic ADRs associated with antitumor drugs in children and adolescent patients, as well as the advances in strategies to cope with ADRs, which consisted of neurotoxicity, hematological toxicity, cardiotoxicity, ADRs of the respiratory system and gastrointestinal system and urinary system, ADRs of the skin and its adnexa, allergic reactions, and other ADRs. For clinicians and researchers, understanding the causes, symptoms, and coping strategies for ADRs caused by anticancer treatments will undoubtedly benefit more children.

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“…Ginseng holds profound significance within traditional Chinese herbal medicine systems (Ren et al, 2023). Numerous studies have substantiated its efficacy in treating a spectrum of ailments, including diabetes (Fan et al., 2020), neurological disorders (Sun et al., 2022), intestinal ulcers (Long et al., 2022), inflammation (Alolga et al., 2020), and diverse forms of cancer (Li et al., 2022). Among its active constituents, which encompass ginsenosides, peptides, polysaccharides, and flavonoids, ginsenosides are notably abundant and exhibit high biological activity, garnering widespread attention (Tang et al., 2022).…”

Section: Introductionmentioning

confidence: 99%

Ginsenoside Rh4 alleviates idiopathic pulmonary fibrosis by enhancing the CXCL9–CXCR3 axis

Yao,

Qu,

Deng

et al. 2024

Food Frontiers

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Idiopathic pulmonary fibrosis (IPF), often likened to a “tumor‐like disease,” proves more lethal than several malignancies. Although prior studies have demonstrated the lung‐protective efficacy of ginsenosides, the precise mechanism underlying their alleviative effect on IPF remains elusive. In this study, we validated the efficacy of the ginsenoside Rh4 in alleviating IPF and delved into the underlying mechanisms. Our data showed that Rh4 intervention significantly reduced mortality and hydroxyproline (HYP) content in mice. It also alleviated the pathological process of IPF by ameliorating phenomena such as alveolar wall thickening induced by IPF. In addition, in vitro cellular experiments confirmed that ginsenoside Rh4 was effective in alleviating transforming growth factor‐β1‐induced IPF model. Further analysis showed that ginsenoside Rh4 significantly reduced collagen fiber production and deposition while inhibiting the coagulation cascade signaling pathway. In addition, ginsenoside Rh4 inhibited the epithelial‐mesenchymal transition(EMT) pathway by promoting the CXCR3‐CXCL9 axis, which ultimately alleviated IPF. In conclusion, our data strongly suggest that ginsenoside Rh4 has the potential to be an innovative prophylactic drug against IPF.

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Potential of ginsenoside Rh2and its derivatives as anti-cancer agents

Cited by 4 publications

References 142 publications

Multi-omics revealed rumen microbiota metabolism and host immune regulation in Tibetan sheep of different ages

Multi-omics revealed rumen microbiota metabolism and host immune regulation in Tibetan sheep of different ages

Anticancer therapy-induced adverse drug reactions in children and preventive and control measures

Ginsenoside Rh4 alleviates idiopathic pulmonary fibrosis by enhancing the CXCL9–CXCR3 axis

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