Potential of Gold Candidates against Human Colon Cancer

Abstract

: Development of novel metallodrugs with pharmacological profile plays a significant role in modern medicinal chemistry and drug design. Metal complexes have shown remarkable clinical results in current cancer therapy. Gold complexes have attained attention due to their high antiproliferative potential. Gold-based drugs are used for the treatment of rheumatoid arthritis. Gold-containing compounds with selective and specific targets are capable to assuage the symptoms of a range of human diseases. Gold (I) species with labile ligands (such as Cl in TEPAuCl) interact with isolated DNA, therefore, this biomolecule has been considered as a target for gold drugs. Gold (I) has a high affinity towards sulfur and selenium, due to this gold (I) drugs readily interact with cysteine or selenocysteine residue of the enzyme to form protein-gold(I) thiolate or protein-gold (I) selenolate complexes that lead to inhibition of the enzyme activity. Au(III) compounds due to their square-planner geometries same as found in cisplatin, representing a good source for the development of anti-tumor agents. This article aims to review the most important applications of gold products in the treatment of human colon cancer and to analyze the complex interplay between gold and the human body.

Advances in gold catalyzed synthesis of quinoid heteroaryls

“…[39][40][41] Previous reviews by our group provided a comprehensive overview of the synthesis pathways for gold complexes 42 and their versatile applications as anti-cancer agents across various therapeutic modalities. 43 The recent review underscores the synthesis of quinoid heteroaryl using gold-catalyzed cascade protocols, emphasizing the need to enhance efficiency, expand substrate diversity, and investigate sustainable approaches. Collaboration between synthetic chemists and pharmaceutical researchers is essential for leveraging these advancements in drug discovery.…”