Potential of<i>Moringa oleifera</i>root and<i>Citrus sinensis</i>fruit rind extracts in the treatment of ulcerative colitis in mice

Gholap, Prashant A; Nirmal, S. A.; Pattan, Shashikant R; Pal, Subodh Chandra; Mandal, Subhash C.

doi:10.3109/13880209.2012.674142

Cited by 22 publications

(11 citation statements)

References 23 publications

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“…The root extract of M. oleifera have been used in the treatment of ulcerative colitis in mice (Gholap et al, 2012). Leaf extracts also produced a significant reduction in stress-induced gastric ulcers and duodenal ulcers induced by cysteamine (Devaraj et al, 2007).…”

Section: Antiulcer Activitymentioning

confidence: 99%

Review on biological and immunomodulatory properties of Moringa oleifera in animal and human nutrition

Jacques¹,

Arnaud²,

FrÃ©jus³

et al. 2020

J. Pharmacognosy Phytother.

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Moringa oleifera, also called "miracle tree" or "tree for life" is a tree native from India. Highly resistant to drought, M. oleifera grows very well in tropical regions, including Benin. It is a plant with very high nutritional values. The different parts of the plant (leaves, fruiots, seeds, roots, bark and flowers) have multiple uses, both therapeutic and nutritional, with uses in human and animals. The leaves for example, are rich in minerals, vitamins, phenolic compounds like phenolic acids, tannins, flavonoids, phytosterols, and alkaloids. It is reported that M. oleifera had anaphylactic, antiulcer, hepatoprotective, anti-inflammatory, antitumor and anticancer, antioxidant, antidiabetic and antimicrobial properties. The present study focuses on the biological properties of Moringa so that it can be used in the treatment of viral diseases in chicken.

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Section: Antiulcer Activitymentioning

confidence: 99%

Review on biological and immunomodulatory properties of Moringa oleifera in animal and human nutrition

Jacques¹,

Arnaud²,

FrÃ©jus³

et al. 2020

J. Pharmacognosy Phytother.

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“…MO possesses different activities such as antiulcerogenic by leaf aqueous extract (Dahiru, Onubiyi, & Umaru, ;) schizonticidal by leaf acetone extract (Patel, Gami, & Patel, ), larvicidal by seed coagulant lectin protein (De Oliveira et al, 2011; Prabhu, Murugan, Nareshkumar, Ramasubramanian, & Bragadeeswaran, ), antiulcerative colitis by root extract (Gholap, Nirmal, Pattan, Pal, & Mandal, ), antiurolithiatic by root wood extract (Karadi et al, ), and antimacrofilaricidal activities by gum exudates (Kushwaha et al, ). The antilarvicidal activity for Aedes ageypt , a vector of dengue virus, was reported in flower extract through trypsin inhibitor activity (Pontual et al, ).…”

Section: Resultsmentioning

confidence: 99%

Biological, nutritional, and therapeutic significance of Moringa oleifera Lam

Dhakad

Ikram

Sharma

et al. 2019

Phytotherapy Research

178

100

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The genus Moringa Adans. comprises 13 species, of which Moringa oleifera Lam. native to India and cultivated across the world owing to its drought and frost resistance habit is widely used in traditional phytomedicine and as rich source of essential nutrients. Wide spectrum of phytochemical ingredients among leaf, flower, fruit, seed, seed oil, bark, and root depend on cultivar, season, and locality. The scientific studies provide insights on the use of M. oleifera with different aqueous, hydroalcoholic, alcoholic, and other organic solvent preparations of different parts for therapeutic activities, that is, antibiocidal, antitumor, antioxidant, anti‐inflammatory, cardio‐protective, hepato‐protective, neuro‐protective, tissue‐protective, and other biological activities with a high degree of safety. A wide variety of alkaloid and sterol, polyphenols and phenolic acids, fatty acids, flavanoids and flavanol glycosides, glucosinolate and isothiocyanate, terpene, anthocyanins etc. are believed to be responsible for the pragmatic effects. Seeds are used with a view of low‐cost biosorbent and coagulant agent for the removal of metals and microbial contamination from waste water. Thus, the present review explores the use of M. oleifera across disciplines for its prominent bioactive ingredients, nutraceutical, therapeutic uses and deals with agricultural, veterinarian, biosorbent, coagulation, biodiesel, and other industrial properties of this “Miracle Tree.”

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“…Gholap et al [140] demonstrated that both the ethanol extract and the aqueous extract of the roots of Moringa oleifera Lam. were effective in the treatment of colitis induced by acetic acid in Swiss mice.…”

Section: Other Familiesmentioning

confidence: 99%

Medicinal Plants in the Treatment of Colitis: Evidence from Preclinical Studies

et al. 2017

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Ulcerative colitis is a chronic inflammatory condition whose treatment includes aminosalicylates, corticosteroids, and immunomodulators. Medicinal plants seem to be an important alternative treatment for this condition. They have been the subject of a great number of studies in recent years. This study was conducted to systematically review the medicinal plants tested in experimental models of ulcerative colitis. We conducted a systematic literature search through specialized databases (PUBMED, SCOPUS, EMBASE, MEDLINE, LILACS, SCIELO, and SCISEARCH) and selected articles published between January 2000 and June 21, 2016 by using ?medicinal plants? and ?ulcerative colitis? as key words. Sixty-eight studies were included, and the families Asteraceae and Lamiaceae presented the largest number of studies, but plants from several other families were cited; many of them have shown good results in experimental animals. However, only a few species (such as Andrographis paniculata and Punica granatum) have undergone clinical tests against ulcerative colitis, and the observation that many preclinical studies reviewed are purely descriptive has certainly contributed to this fact. Chemical constituents (mainly flavonoids and terpenes) seem to play a role in the effects of the plants. Thus, the data herein reviewed reinforce the potential of medicinal plants as a source of alternative approaches to the treatment of ulcerative colitis.

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Potential ofMoringa oleiferaroot andCitrus sinensisfruit rind extracts in the treatment of ulcerative colitis in mice

Cited by 22 publications

References 23 publications

Review on biological and immunomodulatory properties of Moringa oleifera in animal and human nutrition

Review on biological and immunomodulatory properties of Moringa oleifera in animal and human nutrition

Biological, nutritional, and therapeutic significance of Moringa oleifera Lam

Medicinal Plants in the Treatment of Colitis: Evidence from Preclinical Studies

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