Potential of lactic acid bacteria in aflatoxin risk mitigation

Ahlberg, Sara; Joutsjoki, Vesa; Korhonen, Hannu J. T.

doi:10.1016/j.ijfoodmicro.2015.04.042

Cited by 145 publications

(105 citation statements)

References 44 publications

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“…Due to the capacity of certain bacterial strains to bind to mycotoxins, LAB are suggested as a potential biological method to reduce the toxicity of aflatoxins or to avoid their absorption in the human intestine (Ahlberg, Joutsjoki, & Korhonen, ; Wochner et al ., ). The L. acidophilus stood out in numerous studies, most of them evaluated in the model system (El‐Nezami, Kankaanpaa, Salminen, & Ahokas, ; Haskard, El‐Nezami, Kankaanpää, Salminen, & Ahokas, ).…”

Section: Discussionmentioning

confidence: 99%

Detoxification of Aflatoxin B₁ and M₁ by Lactobacillus acidophilus and prebiotics in whole cow's milk

Wochner

Moreira

Kalschne

et al. 2019

Journal of Food Safety

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The detoxification ability of Lactobacillus acidophilus and prebiotics was evaluated by a Plackett‐Burman Design to examine the reduction of concentration and bioaccessibility of aflatoxin B1 (AFB1) and M1 (AFM1) in artificially contaminated whole cow's milk. Six variables were evaluated: AFB1 (3.25–6.0 μg L−1) or AFM1 (1.0–2.0 μg L−1) concentration; incubation time (0–6 h); and inulin, oligofructose, β‐glucan, and polydextrose concentrations (each between 0.00 and 0.75%). All runs achieved reductions of AFB1 (13.53–35.53%) and AFM1 (17.65–71.52%). Comparing with the positive control, the AFB1 bioaccessibility ranged from 23.68 to 72.67% and for AFM1 was 0%. The probiotic, isolated or combined with prebiotics, was efficient in mycotoxin reduction, while the combination of the two reduced the mycotoxin bioaccessibility. The best experimental condition was the highest concentration of AFB1 (6.5 μg L−1) and AFM1 (2.0 μg L−1), incubation time of 0 h and the addition of probiotic and inulin (0.75%).

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Section: Discussionmentioning

confidence: 99%

Detoxification of Aflatoxin B₁ and M₁ by Lactobacillus acidophilus and prebiotics in whole cow's milk

Wochner

Moreira

Kalschne

et al. 2019

Journal of Food Safety

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“…Physical and chemical detoxification methods have some disadvantages, such as loss of nutritional value, altered organoleptic properties, and undesirable effects in the product as well as high cost of equipment and practical difficulties making them infeasible, particularly for lower-income countries (Ahlberg, Joutsjoki, & Korhonen, 2015). However, biological methods based on competitive exclusion by non-toxigenic fungal strains have been reported as a promising approach for mitigating formation of mycotoxins and preventing their absorption into the human body (Farzaneh et al., 2012).…”

Section: Innovative Management Strategies Of Af Reductionmentioning

confidence: 99%

“…However, biological methods based on competitive exclusion by non-toxigenic fungal strains have been reported as a promising approach for mitigating formation of mycotoxins and preventing their absorption into the human body (Farzaneh et al., 2012). Among various microorganisms, lactic acid bacteria (LAB) namely Lactobacillus , Bifidobacterium , Propionibacterium , and Lactococcus are reported to be active in terms of binding AF-B 1 and AF-M 1 (Ahlberg et al., 2015, El-Nezami and Gratz, 2011, Peltonen et al., 2001). The binding is most likely a surface phenomenon with a significant involvement of lactic acid and other metabolites such as phenolic compounds, hydroxyl fatty acids, hydrogen peroxide, reuterin, and proteinaceous compounds produced by LAB (Dalié, Deschamps, & Richard-Forget, 2010).…”

Section: Innovative Management Strategies Of Af Reductionmentioning

confidence: 99%

Innovative technologies to manage aflatoxins in foods and feeds and the profitability of application – A review

Udomkun¹,

et al. 2017

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Aflatoxins are mainly produced by certain strains of Aspergillus flavus, which are found in diverse agricultural crops. In many lower-income countries, aflatoxins pose serious public health issues since the occurrence of these toxins can be considerably common and even extreme. Aflatoxins can negatively affect health of livestock and poultry due to contaminated feeds. Additionally, they significantly limit the development of international trade as a result of strict regulation in high-value markets. Due to their high stability, aflatoxins are not only a problem during cropping, but also during storage, transport, processing, and handling steps. Consequently, innovative evidence-based technologies are urgently required to minimize aflatoxin exposure. Thus far, biological control has been developed as the most innovative potential technology of controlling aflatoxin contamination in crops, which uses competitive exclusion of toxigenic strains by non-toxigenic ones. This technology is commercially applied in groundnuts maize, cottonseed, and pistachios during pre-harvest stages. Some other effective technologies such as irradiation, ozone fumigation, chemical and biological control agents, and improved packaging materials can also minimize post-harvest aflatoxins contamination in agricultural products. However, integrated adoption of these pre- and post-harvest technologies is still required for sustainable solutions to reduce aflatoxins contamination, which enhances food security, alleviates malnutrition, and strengthens economic sustainability.

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“…In animals, AFB 1 has nutritional and immunologic consequences that may contribute to lower body weight gain and impaired reproductive eficiency (EWUOLA et al, 2014;BHATNAGAR-MATHUR et al, 2015;TREBAK et al, 2015). In addition, acute exposure to alatoxins can cause alatoxicosis, and in cases of severe hepatotoxicity the mortality rate is approximately 25% (AHLBERG et al, 2015). AFB 1 may also affect early growth and some aspects of human immunity and nutrition (WILLIAMS et al, 2004).…”

Section: Effects Of Alatoxin Bmentioning

confidence: 99%

“…Several strategies have been developed to reduce the risks of AFB 1 exposure (DIAO et al, 2013;WANG et al, 2015), including degradation, destruction, inactivation and removal of AFB 1 through chemical, physical, and biological methods (GIORDANO et al, 2012;AHLBERG et al, 2015;NONES et al, 2015a;2015b;WANG et al, 2015). These methods are usually added to human foods or animal feeds; however, their use has some limitations, such as alteration in organoleptic characteristics and nutritional values of foods and feeds (MADRIGAL-SANTILLÁN et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Measures against aflatoxin B1: a brief review about the use of flavonoids and clays

Riella

Nones

2017

Biotemas

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ResumoMedidas para o controle da alatoxina B 1 : uma breve revisão sobre o uso de lavonoides e argilas. A alatoxina B 1 (AFB 1 ) é uma das micotoxinas mais abundantes e tóxicas produzidas por cepas toxigênicas.Esta substância afeta a viabilidade celular, sendo capaz de induzir a morte, tanto de células humanas, quanto de células animais. Medidas vêm sendo adotadas para minimizar os danos causados pela AFB 1 , incluindo a utilização de lavonoides (compostos polifenólicos extraídos de plantas) e bentonitas (um tipo de argila). Nesta revisão, as características físico-químicas da AFB 1 e seus efeitos em diferentes tipos de células, in vitro e in vivo, foram abordados. Além disso, a capacidade de proteção celular a partir de substâncias e materiais naturais, tais como lavonoides e bentonita, foi brevemente descrita. Também relatamos os efeitos econômicos causados pelas micotoxinas e sugerimos alternativas (lavonoides e bentonita) para novas abordagens terapêuticas visando combater a toxicidade causada por estas substâncias (AFB 1 ).Palavras-chave: Alatoxina B 1 ; Argila; Flavonoides; Mecanismo de ação AbstractAlatoxin B 1 (AFB 1 ) is one of the most abundant and toxic mycotoxins produced by toxigenic strains. This substance affects cell viability, inducing cell death in several human and animal cells. Measures have been taken to minimize damage caused by AFB 1 , including the use of lavonoids (polyphenolic compounds extracted from plants) and bentonites (a type of clay). In this review, the physicochemical characteristics of AFB 1 and its effects on different cells are discussed. Furthermore, the cellular protective effects of lavonoids and bentonites are briely reviewed. Finally, the emerging view of the economic effects caused by mycotoxins is briely discussed, along with how lavonoids and bentonites might open new pathways to develop approaches to ight the toxic effects caused by alatoxins.

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Potential of lactic acid bacteria in aflatoxin risk mitigation

Cited by 145 publications

References 44 publications

Detoxification of Aflatoxin B₁ and M₁ by Lactobacillus acidophilus and prebiotics in whole cow's milk

Detoxification of Aflatoxin B₁ and M₁ by Lactobacillus acidophilus and prebiotics in whole cow's milk

Innovative technologies to manage aflatoxins in foods and feeds and the profitability of application – A review

Measures against aflatoxin B1: a brief review about the use of flavonoids and clays

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Potential of lactic acid bacteria in aflatoxin risk mitigation

Cited by 145 publications

References 44 publications

Detoxification of Aflatoxin B1 and M1 by Lactobacillus acidophilus and prebiotics in whole cow's milk

Detoxification of Aflatoxin B1 and M1 by Lactobacillus acidophilus and prebiotics in whole cow's milk

Innovative technologies to manage aflatoxins in foods and feeds and the profitability of application – A review

Measures against aflatoxin B1: a brief review about the use of flavonoids and clays

Contact Info

Product

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About

Detoxification of Aflatoxin B₁ and M₁ by Lactobacillus acidophilus and prebiotics in whole cow's milk

Detoxification of Aflatoxin B₁ and M₁ by Lactobacillus acidophilus and prebiotics in whole cow's milk