2021
DOI: 10.1002/smll.202005241
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Potential of Magnetic Hyperthermia to Stimulate Localized Immune Activation

Abstract: Magnetic hyperthermia (MH) harnesses the heat‐releasing properties of superparamagnetic iron oxide nanoparticles (SPIONs) and has potential to stimulate immune activation in the tumor microenvironment whilst sparing surrounding normal tissues. To assess feasibility of localized MH in vivo, SPIONs are injected intratumorally and their fate tracked by Zirconium‐89‐positron emission tomography, histological analysis, and electron microscopy. Experiments show that an average of 49% (21–87%, n = 9) of SPIONs are re… Show more

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Cited by 48 publications
(36 citation statements)
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“…Some cytostatics interact with cells during the S-phase of division so that hyperthermia could enhance the effect of these drugs [ 2 ]. The fast rate of cell divisions and hypoxia characteristic of cancer makes cancer cells more susceptible to hyperthermy [ 93 ]. It has also been shown that the combination of gold nanowires with hyperthermia can damage the cytoskeleton and affect the migration of cancer cells [ 94 ] or synergistically support the inactivation of the complex of oncogenic proteins PML/RARα [ 95 , 96 ].…”
Section: Hyperthermiamentioning
confidence: 99%
“…Some cytostatics interact with cells during the S-phase of division so that hyperthermia could enhance the effect of these drugs [ 2 ]. The fast rate of cell divisions and hypoxia characteristic of cancer makes cancer cells more susceptible to hyperthermy [ 93 ]. It has also been shown that the combination of gold nanowires with hyperthermia can damage the cytoskeleton and affect the migration of cancer cells [ 94 ] or synergistically support the inactivation of the complex of oncogenic proteins PML/RARα [ 95 , 96 ].…”
Section: Hyperthermiamentioning
confidence: 99%
“…Moreover, even biological requirements like exclusion of toxicity, iron leaching and non-specific interactions must be taken into account when designing bioferrofluids. The crucial issues are biocompatibility and colloidal stability which involve nano-bio interactions [164][165][166] governed by the solid-liquid interface that forms on NPs' surface in the surrounding milieu and comes into contact with biological entities, protein corona formation, [167][168][169] immune response, 170,171 etc.…”
Section: On the Colloidal Stability Of Ferrofluids And Bioferrofluidsmentioning
confidence: 99%
“…Thomas J. Carter et al [51] prepared a dextran-coated SPIONs, i. e., perimag-COOH, which possessed a high-efficiency heating capacity as compared to other similar SPIONs available commercially. After establishing the localization of the particles, preclinical magnetic alternating current hyperthermia (MACH) system was used to generate AMF, and this could generate clinically relevant and measurable temperature rises in the subcutaneous in vivo syngeneic mouse model.…”
Section: Only Mht-induced Tumor Immunitymentioning
confidence: 99%