Potential of Nanostructured Lipid Carriers in Nose to Brain Targeting for Alzheimer’s Disease

Abstract

Due to the number of disorders associated with oral, parenteral, rectal and other routes of administration, Scientists are increasingly interested in exploring the potential nasal uses of various drugs. Intranasal drug delivery systems are commonly known to treat ailments such as colds, coughs, and rhinitis. This review therefore focuses on new research on nanostructured lipid transporters for nasal brain targets that are beneficial for various neurodegenerative disorders. Here highlighted one is Alzheimer disorder. The incorporation of drugs into nanoparticles selects drug delivery from the nose to the brain due to high drug absorption through the nasal mucosa and many benefits of brain-targeted drug delivery such as avoidance of BBB could be a talent approach. This is achieved by pathway mechanism. NLC as a lipid-containing drug delivery system, is an established method for pharmaceutical preparation for all major types of DDS in Nano science. NLC is a new type of DDS, stable in various environments and capable of forming centralized dispersions. This article covers various processes of NLC production/ preparation and its applications with current advances. NLC can increase drug delivery to target organs, alter the pharmacokinetics of drug carriers to enhance therapeutic effects and reduce harmful side effects.