Potential of natural astaxanthin in alleviating the risk of cytokine storm in COVID-19

Talukdar, Jayanta; Bhadra, Bhaskar; Dattaroy, Tomal; Nagle, Vinod; Dasgupta, Santanu

doi:10.1016/j.biopha.2020.110886

Cited by 83 publications

(44 citation statements)

References 138 publications

(515 reference statements)

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“…The first one is related to effects of astaxanthin on antioxidant parameters in stroke patients, whereas the second one relied on effects of a dietary supplement containing astaxanthin on inflammation markers (Birudaraju et al 2020). Talukdar et al (2020a) brought arguments to consider this compound as a serious natural molecule to alleviate the risk of cytokine storm in some Covid-19 patients thanks to its anti-inflammatory properties. Elsewhere, in a study conducted in vitro on human papilloma virus (HPV), astaxanthin prevented HPV L1 protein (capsid protein) by binding on human sperm membrane.…”

Section: Discussionmentioning

confidence: 99%

“…Numerous publications have reviewed the generic properties of algae in these areas (Mimouni et al 2012). For example, the immune response in the cytokines which is tested by Talukdar et al (2020aTalukdar et al ( , 2020b with astaxanthin. Griffithsin, a lectin isolated the from red alga Griffithsia, has shown activity on protein S of MERS-CoV (Middle East Respiratory Syndrome Coronavirus) (Millet et al 2016).…”

Section: Sars-cov-2mentioning

confidence: 99%

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Docking and in silico toxicity assessment of Arthrospira compounds as potential antiviral agents against SARS-CoV-2

Petit¹,

Vernès²,

Cadoret³

2021

J Appl Phycol

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A race is currently being launched as a result of the international health situation. This race aims to find, by various means, weapons to counter the Covid-19 pandemic now widespread on all continents. The aquatic world and in particular that of photosynthetic organisms is regularly highlighted but paradoxically little exploited in view of the tremendous possibilities it offers. Computational tools allow not only to clear the existence and activity of many molecules but also to model their relationships with receptors identified in potential hosts. On a routine basis, our laboratory carries out a research activity on functionalities of molecules derived from algae using in silico tools. We have implemented our skills in algae biology and in modeling, as tests in order to identify molecules expressed by the genus Arthrospira showing an antiviral potential and more particularly anti-SARS-CoV-2. Using consensus docking and redocking with Autodock Vina and SwissDock, we were able to identify several promising molecules from Arthrospira: phycocyanobilin, phycoerythrobilin, phycourobilin, and folic acid. These four compounds showed reliable binding energies comprised between − 6.95 and − 7.45 kcal.mol −1 in Autodock Vina and between − 9.285 and − 10.35 kcal.mol −1 with SwissDock. Toxicity prediction as well as current regulations provided promising arguments for the inclusion of these compounds in further studies to assess their ability to compete with the SARS-CoV-2/ACE2 complex both in vitro and in vivo.

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Section: Discussionmentioning

confidence: 99%

Section: Sars-cov-2mentioning

confidence: 99%

Docking and in silico toxicity assessment of Arthrospira compounds as potential antiviral agents against SARS-CoV-2

Petit¹,

Vernès²,

Cadoret³

2021

J Appl Phycol

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“…One of the major pathways for NF-ĸβ activation after CoV infection is the myeloid differentiation primary response 88 (MyD88) pathway through pattern recognition receptors (PRRs). This pathway induces a variety of pro-inflammatory cytokines, including interleukin (IL)-6 and TNF-α [ 61 , 156 ]. ACE2 is endocytosed along with SARS-CoV-2, resulting in the reduction of ACE2 on cells, followed by an increase in serum angiotensin II (Ang II) [62] .…”

Section: Overview On Sars-cov-2 Infectionmentioning

confidence: 99%

“…Ang II acts both as a vasoconstrictor and pro-inflammatory cytokine via the Ang II-receptor type 1 (AT1R). The Ang II-AT1R axis activates NF-ĸβ and induces tumor necrosis factor-α (TNF-α), epidermal growth factor receptor (EGFR), and soluble form of IL-6 receptor (sIL-6Rα) via disintegrin and metalloprotease 17 (ADAM17) [ 61 , 62 , 156 ]. Thus, the higher the viral load, the lower the concentration of ACE-2 due to virus binding, which causes increased levels of Ang II in the serum, thus activating the NF-ĸβ pathway.…”

Section: Overview On Sars-cov-2 Infectionmentioning

confidence: 99%

Bioactivity, bioavailability, and gut microbiota transformations of dietary phenolic compounds: implications for COVID-19

Augusti

Conterato

Denardin

et al. 2021

The Journal of Nutritional Biochemistry

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The outbreak of mysterious pneumonia at the end of 2019 is associated with widespread research interest worldwide. The coronavirus disease-19 (COVID-19) targets multiple organs through inflammatory, immune, and redox mechanisms, and no effective drug for its prophylaxis or treatment has been identified until now. The use of dietary bioactive compounds, such as phenolic compounds (PC), has emerged as a putative nutritional or therapeutic adjunct approach for COVID-19. In the present study, scientific data on the mechanisms underlying the bioactivity of PC and their usefulness in COVID-19 mitigation are reviewed. In addition, antioxidant, antiviral, anti-inflammatory, and immunomodulatory effects of dietary PC are studied. Moreover, the implications of digestion on the putative benefits of dietary PC against COVID-19 are presented by addressing the bioavailability and biotransformation of PC by the gut microbiota. Lastly, safety issues and possible drug interactions of PC and their implications in COVID-19 therapeutics are discussed.

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“…primary antiviral compounds, while further validation via clincal studies is required [49]. In brief, algae and algae-derived extracts can be used as the supplement to prevent viral infection or to help during the post-treatment care of the COVID-19 patients, particularly on the side effects associated with drug toxicity.…”

Section: Indiamentioning

confidence: 99%

Can algae contribute to the war with Covid-19?

et al. 2021

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The world at large is facing a new threat with the emergence of the Coronavirus Disease 2019 (COVID-19) pandemic. Though imperceptible by the naked eye, the medical, sociological and economical implications caused by this newly discovered virus have been and will continue to be a great impediment to our lives. This health threat has already caused over two million deaths worldwide in the span of a year and its mortality rate is projected to continue rising. In this review, the potential of algae in combating the spread of COVID-19 is investigated since algal compounds have been tested against viruses and algal anti-inflammatory compounds have the potential to treat the severe symptoms of COVID-19. The possible utilization of algae in producing valueadded products such as serological test kits, vaccines, and supplements that would either mitigate or hinder the continued health risks caused by the virus is prominent. Many of the characteristics in algae can provide insights on the development of microalgae to fight against SARS-CoV-2 or other viruses and contribute in manufacturing various green and high-value products.

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Potential of natural astaxanthin in alleviating the risk of cytokine storm in COVID-19

Abstract: Graphical abstract

Cited by 83 publications

References 138 publications

Docking and in silico toxicity assessment of Arthrospira compounds as potential antiviral agents against SARS-CoV-2

Docking and in silico toxicity assessment of Arthrospira compounds as potential antiviral agents against SARS-CoV-2

Bioactivity, bioavailability, and gut microbiota transformations of dietary phenolic compounds: implications for COVID-19

Can algae contribute to the war with Covid-19?

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