Potential of Pluripotent Stem Cells for the Replacement of Inner Ears

Nishimura, Koji; Nakagawa, Takayuki; Ito, Juichi

doi:10.5772/10541

Cited by 1 publication

(1 citation statement)

References 56 publications

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“…Matsuoka and colleagues investigated the potential of MSCs to adopt properties of SGNs in vivo [108]. Identification of stem cells in the human fetal cochlea [109] contributes to the study stem cell biology of the auditory organ in humans, while advances in identification of stem cells have been made in rodents [110].…”

Section: Stem Cells Therapymentioning

confidence: 99%

Advances in Genetic Diagnosis and Treatment of Hearing Loss — A Thirst for Revolution

Pandey¹,

Pandey²

2015

Update on Hearing Loss

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Despite the significant advances in understanding the molecular basis of hearing loss, precise identification of genetic cause still presents some difficulties, owing to phenotypical variation. Gene discovery efforts for hearing disorders are complicated by extreme heterogeneity. Mutations in some of these genes, such as GJB , MYO A, CDH , OTOF, SLC A , TMC , are quite common and responsible for hearing loss. Clinical exome sequencing is a highly complex molecular test that analyzes the exons or coding regions of thousands of genes simultaneously, using next-generation sequencing techniques. The development of a biological method for the repair, regeneration, and replacement of hair cells of the damaged cochlea has the potential to restore normal hearing. "t present, gene therapy and stem cells are two promising therapeutic applications for hearing disorders. Gene therapy and stem cell treatment have still a long way to go before these treatments will be available to use in humans. Therefore, existing measures must focus on the prevention of hearing loss to decrease the frequency of genetic hearing loss. Over time, genetic diagnostic tests will become available most rapidly, followed by targeted gene therapy or various permutations of progenitor cell transplantation, and eventually, the preventive interventions for a wider range of hearing impaired patients.

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Section: Stem Cells Therapymentioning

confidence: 99%