Potential of Probiotics as Alternative Sources for Antibiotics in Food Production Systems

Thapa, Sarina Pradhan; Koirala, Sushil; Anal, Anil Kumar

doi:10.1002/9781119702160.ch8

Cited by 3 publications

(3 citation statements)

References 71 publications

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“…The HePS synthesized by L. rhamnosus SHA111 had good antioxidant activity with high values for scavenging activity towards hydroxyl and superoxide radicals and reducing power, as well as high antitumor activity against human colon cancer Caco-2 cells [32]. Antimutagenic activity (binding ability to different mutagens, such as heterocyclic amines, 4-nitroquinoline-N-oxide and 2-nitrofluorine) from EPS-producing lactobacilli (L. plantarum and L. rhamnosus) was also reported [117,118].…”

Section: Anti-cancer Activitymentioning

confidence: 98%

Biological Functions of Exopolysaccharides from Lactic Acid Bacteria and Their Potential Benefits for Humans and Farmed Animals

Werning

Hernández-Alcántara

Ruiz

et al. 2022

Foods

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Lactic acid bacteria (LAB) synthesize exopolysaccharides (EPS), which are structurally diverse biopolymers with a broad range of technological properties and bioactivities. There is scientific evidence that these polymers have health-promoting properties. Most commercialized probiotic microorganisms for consumption by humans and farmed animals are LAB and some of them are EPS-producers indicating that some of their beneficial properties could be due to these polymers. Probiotic LAB are currently used to improve human health and for the prevention and treatment of specific pathologic conditions. They are also used in food-producing animal husbandry, mainly due to their abilities to promote growth and inhibit pathogens via different mechanisms, among which the production of EPS could be involved. Thus, the aim of this review is to discuss the current knowledge of the characteristics, usage and biological role of EPS from LAB, as well as their postbiotic action in humans and animals, and to predict the future contribution that they could have on the diet of food animals to improve productivity, animal health status and impact on public health.

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Section: Anti-cancer Activitymentioning

confidence: 98%

Biological Functions of Exopolysaccharides from Lactic Acid Bacteria and Their Potential Benefits for Humans and Farmed Animals

Werning

Hernández-Alcántara

Ruiz

et al. 2022

Foods

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show abstract

“…L. plantarum and L. rhamnosus -derived EPSs can bind to various mutagens, like 2-nitrofluorene, heterocyclic amines, and 4-nitroquinoline-N-oxide reduce their mutagenic potential (Tsuda et al 2008 ; Thapa and Zhang 2009 ).…”

Section: Classification and Properties Of Microbial Epssmentioning

confidence: 99%

Recent advances in the biological activities of microbial exopolysaccharides

Salimi

Farrokh

2023

World J Microbiol Biotechnol

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Microbial exopolysaccharides (EPSs) are valuable extracellular macromolecules secreted as capsules or slime layers. Various microorganisms, including bacteria, yeasts, fungi, and algae have been studied for their ability to produce EPSs. Microbial EPSs exist as homopolysaccharides or heteropolysaccharides with various properties such as different monosaccharide compositions, structural conformation, molecular weight, and functional groups. They are cost-effective alternatives to plant and animal-derived polysaccharides because the microbial cells produced them in large quantities by biotechnological processes using low-cost substrates such as industrial wastes in a short time. Microbial EPSs are safe, biodegradable, and compatible polymers. They have extensive bioactivities, including antibacterial, antifungal, antiviral, antioxidant, antitumor, antidiabetic, antiulcer, anticoagulant, antiaging, immunomodulatory, wound healing, and cholesterol-lowering activities. Microbial EPSs owing to biological activities, special biochemical structures, and attractive physicochemical properties find plenty of potential applications in various industries. The enhancement of the production of EPSs and improving their properties can be provided by genetic engineering methods. The current review aims to provide a comprehensive examination of the therapeutic activities of microbial EPSs in infectious diseases and metabolic disorders, with a focus on the mechanisms involved. Also, the effect of the physicochemical characteristics of EPSs on these bioactivities was discussed to reveal the structure-activity relationship.

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“…Direct effects of probiotics on other microbes convey two primary mechanisms of action: inducing their antimicrobial effects by producing bacteriocins (peptides naturally synthesized by ribosomes) and secreting bile acids; both destroy pathogenic bacterial membranes -probiotics aid in decreasing the spread of antibiotic-resistant bacteria [29]. Maintaining a balanced microbiota by administering probiotics and probiotic-based foods and beverages will reduce antibiotic-resistant bacterial infections [86,95]. Lactobacillus strains have been shown to produce neuroactive and neuroendocrine molecules to reduce stress-induced corticosterone and anxiety-and depression-related behavior [8].…”

Section: The Gut Microbiome As a Micro-ecosystem In Dictating Human H...mentioning

confidence: 99%

The Conceptual Approach to the Use of Postbiotics Based on Bacterial Membrane Nanovesicles for Prophylaxis of Astronauts’ Health Disorders

ORLOVSKA¹,

PODOLICH²,

KUKHARENKO³

et al. 2022

Kosm. nauka tehnol.

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The functional fermented foods containing live microorganisms and their components are necessary for the normal functioning of the human body as normal gut microbiota needs fuel from external microbial organisms and their nanostructures — membrane vesicles (MVs), excreting outside. The сoncept that MVs may contribute to astronauts’ health probably to the same extent as their parental microbial cells do and be a temporary substitute for living microbial cells until we know more about the behavior of microbes in the space environment. The advantage of MVs is that they are not alive and cannot be changed under unfavorable conditions as microbial organisms may be. As the model, we selected MVs of a robust to environmental factors kombucha multimicrobial culture (KMC), known for its health-promoting characteristics for humans. We exposed KMC on the International Space Station in a hybrid space/Mars-like environment for an initial proof-of-concept stage. In the exposure study, KMC has survived a long-term period in harsh conditions, and the MVs generated by post-flight kombucha community members did not acquire toxicity, despite the changed membrane composition in the environment imitated conditions on the Mars surface. This observation, together with our KMC metagenomic and comparative genomic analyses of the dominant KMC bacterium Komagataeibacter oboediens, showed that the ground reference sample and spaceexposed ones were similar in topology and maintained their stability. In the next stage, we assessed the fitness, safety, and biodistribution of MVs of post-flight K. oboediens and showed that they were altered, but the modifications in membrane structure did not result in toxicity acquisition. Our proof-of-concept strategy is discussed in this review in line with the literature.

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Potential of Probiotics as Alternative Sources for Antibiotics in Food Production Systems

Cited by 3 publications

References 71 publications

Biological Functions of Exopolysaccharides from Lactic Acid Bacteria and Their Potential Benefits for Humans and Farmed Animals

Biological Functions of Exopolysaccharides from Lactic Acid Bacteria and Their Potential Benefits for Humans and Farmed Animals

Recent advances in the biological activities of microbial exopolysaccharides

The Conceptual Approach to the Use of Postbiotics Based on Bacterial Membrane Nanovesicles for Prophylaxis of Astronauts’ Health Disorders

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