Potential of quercetin in combination with antioxidants of different polarity incorporated in oil-in-water nanoemulsions to control enzymatic browning of apples

Mendoza–Wilson, Ana María; Balandrán‐Quintana, René Renato; Valdés-Covarrubias, Miguel Ángel; Cabellos, José Luis

doi:10.1016/j.molstruc.2022.132372

Cited by 14 publications

(6 citation statements)

References 69 publications

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“…In addition, a hydrophobic interaction with the monooleate (apolar) of the surfactant and the carbon chains of MCT in the nucleus generated changes in size and PDI. A similar effect was described by Mendoza-Wilson et al [ 39 ] when encapsulating Qt in an NE stabilized only with Tween 65.…”

Section: Resultssupporting

confidence: 81%

“…F2Qt to F6Qt presented an increase ( p < 0.05) in size and PDI compared to their control NEs (without Qt) due to the additional effect of Qt on the NE. Qt can interact with QPA via different interaction mechanisms (hydrogen bonding, hydrophobic, and van der Waals) to achieve its inclusion in the nanodroplet, causing molecular rearrangements [ 39 ]. The increase in the zeta potential was due to the restructuring of the QPA complex in the presence of Qt, favoring the exposure of negative patches of QP and alginate to the interfacial zone of the NE, which were negatively charged because they were above its pI (4.50) and pKa (3–3.5), respectively [ 15 , 17 ].…”

Section: Resultsmentioning

confidence: 99%

Section: Preparation and Characterization Of Nesmentioning

confidence: 99%

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Nanoemulsions Based on Soluble Chenopodin/Alginate Complex for Colonic Delivery of Quercetin

Intiquilla,

Arazo,

Gamboa

et al. 2024

Antioxidants

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Inflammatory bowel disease (IBD) is an autoimmune disorder caused by uncontrolled immune activation and the subsequent destruction of the colon tissue. Quercetin (Qt) is a natural antioxidant and anti-inflammatory agent proposed as an alternative to mitigate IBD. However, its use is limited by its low oral bioavailability. This study aimed to develop nanoemulsions (NEs) based on a soluble chenopodin/alginate (QPA) complex and Tween 80 (T80), intended for the colonic release of Qt, activated by the pH (5.4) and bacteria present in the human colonic microbiota. NEs with different ratios of QPA/Tw80 (F1-F6) were prepared, where F4Qt (60/40) and F5Qt (70/30) showed sizes smaller than 260 nm, PDI < 0.27, and high encapsulation efficiency (>85%). The stability was evaluated under different conditions (time, temperature, pH, and NaCl). The DSC and FTIR analyses indicated hydrophobic and hydrogen bonding interactions between QPA and Qt. F4Qt and F5Qt showed the greater release of Qt in PBS1X and Krebs buffer at pH 5.4 (diseased condition), compared to the release at pH 7.4 (healthy condition) at 8 h of study. In the presence of E. coli and B. thetaiotaomicron, they triggered the more significant release of Qt (ƒ2 < 50) compared to the control (without bacteria). The NEs (without Qt) did not show cytotoxicity in HT-29 cells (cell viability > 80%) and increased the antioxidant capacity of encapsulated Qt. Therefore, these NEs are promising nanocarriers for the delivery of flavonoids to the colon to treat IBD.

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Section: Resultssupporting

confidence: 81%

Section: Resultsmentioning

confidence: 99%

Section: Preparation and Characterization Of Nesmentioning

confidence: 99%

See 1 more Smart Citation

Nanoemulsions Based on Soluble Chenopodin/Alginate Complex for Colonic Delivery of Quercetin

Intiquilla,

Arazo,

Gamboa

et al. 2024

Antioxidants

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“…These are coupled to a local optimizer of any electronic structure package. Examples include the Ab initio Random Structure Searching approach ( Pickard and Needs, 2011 ), simulated annealing ( Kirkpatrick et al, 1983 ; Metropolis et al, 1953 ; Xiang and Gong, 2000 ; Xiang et al, 2013 ; Vlachos et al, 1993 ; Granville et al, 1994 ), the kick methodology ( Pan et al, 2014 ; Cui et al, 2015 ; Vargas-Caamal et al, 2016b , a ; Cui et al, 2017 ; Vargas-Caamal et al, 2015 ; Flórez et al, 2016 ; Ravell et al, 2018 ; Hadad et al, 2014 ; Saunders, 2004 , 1987 ; Grande-Aztatzi et al, 2014 ; Mendoza-Wilson et al, 2022 ), and genetic algorithms ( Guo et al, 2017 ; Dong et al, 2018 ; Mondal et al, 2016 ; Ravell et al, 2018 ; Grande-Aztatzi et al, 2014 ; Rodríguez-Kessler et al, 2017 ; Alexandrova et al, 2004 ; Buelna-Garcia et al, 2021 ). Global minimum structure searches at the DFT level are too computationally expensive to be applied to intermediate and large cluster sizes since, as mentioned earlier, the number of candidates increases exponentially with the number of atoms.…”

Section: Free Energy Surface Exploration Methods and Computational De...mentioning

confidence: 99%

Relative Populations and IR Spectra of Cu38 Cluster at Finite Temperature Based on DFT and Statistical Thermodynamics Calculations

et al. 2022

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The relative populations of Cu38 isomers depend to a great extent on the temperature. Density functional theory and nanothermodynamics can be combined to compute the geometrical optimization of isomers and their spectroscopic properties in an approximate manner. In this article, we investigate entropy-driven isomer distributions of Cu38 clusters and the effect of temperature on their IR spectra. An extensive, systematic global search is performed on the potential and free energy surfaces of Cu38 using a two-stage strategy to identify the lowest-energy structure and its low-energy neighbors. The effects of temperature on the populations and IR spectra are considered via Boltzmann factors. The computed IR spectrum of each isomer is multiplied by its corresponding Boltzmann weight at finite temperature. Then, they are summed together to produce a final temperature-dependent, Boltzmann-weighted spectrum. Our results show that the disordered structure dominates at high temperatures and the overall Boltzmann-weighted spectrum is composed of a mixture of spectra from several individual isomers.

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“…The antioxidants could help inhibiting browning by reacting with oxygen, as well as with intermediate products, thereby breaking the chain reaction and suppressing melanin formation (Moon et al., 2020). A study applied the oil‐in‐water nanoemulsion incorporated with four antioxidants together—quercetin, quercetin‐3‐rhamnoside, ascorbic acid, and α‐tocopherol (each 100 μM)—to Granny Smith fresh‐cut (Mendoza‐Wilson et al., 2022). This composition inhibited 41% PPO activity, and inhibited browning (based on Δ L ‐value) between 74% to 81% during 6 h, better than while using only two or three antioxidants.…”

Section: Inhibition Of Enzymatic Browningmentioning

confidence: 99%

Enzymatic browning in apple products and its inhibition treatments: A comprehensive review

Arnold

Gramza‐Michałowska

2022

Comp Rev Food Sci Food Safe

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Apple (Malus domestica) is widely consumed by consumers from various regions. It contains a high number of phenolic compounds (majorly hydroxybenzoic acids, hydroxycinnamic acids, flavanols, flavonols, dihydrochalcones, and anthocyanins) and antioxidant activity, which are beneficial for human health. The trends on healthy and fresh food have driven the food industry to produce minimally processed apple, such as fresh-cut, puree, juice, and so on without degrading the quality of products. Enzymatic browning is one of the problems found in minimally processed apple as it causes the undesirable dark color as well as the degradation of phenolics and antioxidant activity, which then reduces the health benefits of apple. Proper inhibition is needed to maintain the quality of minimally processed apple with minimal changes in sensory properties. This review summarizes the inhibition of enzymatic browning of apple products based on recent studies using the conventional and nonconventional processing, as well as using synthetic and natural antibrowning agents. Nonconventional processing and the use of natural antibrowning agents can be used as promising treatments to prevent enzymatic browning in minimally processed apple products. Combination of 2-3 treatments can improve the effective inhibition of enzymatic browning. Further studies, such on as other potential natural antibrowning agents and their mechanisms of action, should be conducted.

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Potential of quercetin in combination with antioxidants of different polarity incorporated in oil-in-water nanoemulsions to control enzymatic browning of apples

Cited by 14 publications

References 69 publications

Nanoemulsions Based on Soluble Chenopodin/Alginate Complex for Colonic Delivery of Quercetin

Nanoemulsions Based on Soluble Chenopodin/Alginate Complex for Colonic Delivery of Quercetin

Relative Populations and IR Spectra of Cu38 Cluster at Finite Temperature Based on DFT and Statistical Thermodynamics Calculations

Enzymatic browning in apple products and its inhibition treatments: A comprehensive review

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