Potential of resveratrol in the treatment of heart failure

Raj, Pema; Louis, Xavier Lieben; Thandapilly, Sijo Joseph; Movahed, Ali; Zieroth, Shelley; Netticadan, Thomas

doi:10.1016/j.lfs.2013.12.011

Cited by 98 publications

(93 citation statements)

References 102 publications

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“…Resveratrol is found naturally in a variety of foods including grape skins, blueberries, cranberries, Polygonum cuspidatum (Japanese knot-weed), peanuts and red wines (20)(21)(22)(23) . Numerous studies have reported the benefits of resveratrol administration in the treatment of various CVD including coronary artery disease, cardiac arrhythmias, myocardial infarction, heart failure and cardiac fibrosis (20)(21)(22)(23)(24) . The cardioprotective effects of resveratrol are mostly attributable to its antioxidant properties, particularly its free-radical scavenging capacity and ability to up-regulate the expression of endogenous antioxidant genes (25)(26)(27) .…”

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confidence: 99%

Resveratrol shows neuronal and vascular-protective effects in older, obese, streptozotocin-induced diabetic rats

et al. 2016

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Diabetes-induced CVD is the most significant complication of prolonged hyperglycaemia. The aim of this study was to determine whether resveratrol, a polyphenol antioxidant compound, when administered at a dose that can be reasonably obtained through supplementation could prevent the development of cardiovascular complications in older, obese, diabetic rats. Diabetes was induced in 6-month old, obese, male Wistar rats via a single intravenous dose of streptozotocin (65 mg/kg). Randomly selected animals were administered resveratrol (2 mg/kg) via oral gavage daily for 8 weeks. Body weights, blood glucose levels, food intake and water consumption were monitored, and assessments of vascular reactivity, tactile allodynia and left ventricular function were performed. Resveratrol therapy significantly improved tactile allodynia and vascular contractile functionality in diabetic rats (P < 0·05). There were no significant changes in standardised vasorelaxation responses, plasma glucose concentrations, water consumption, body weight, left ventricular hypertrophy, kidney hypertrophy, heart rate or left ventricular compliance with resveratrol administration. Resveratrol-mediated improvements in vascular and nerve function in old, obese, diabetic rats were associated with its reported antioxidant effects. Resveratrol did not improve cardiac function nor mitigate the classic clinical symptoms of diabetes mellitus (i.e. hyperglycaemia, polydypsia and a failure to thrive). This suggests that supplementation with resveratrol at a dose achievable with commercially available supplements would not produce significant cardioprotective effects in people with diabetes mellitus.

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confidence: 99%

Resveratrol shows neuronal and vascular-protective effects in older, obese, streptozotocin-induced diabetic rats

et al. 2016

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“…In addition, RSV has effect on myocardial ischemia. Inhibition of platelet aggregation and a potential regeneration of tissue in the infarcted area are some RSV effects on myocardial ischemia (Raj et al., 2014). One of protective mechanisms by RSV in cardiomyocytes is induction of autophagy via SIRT‐1 and AMPK activation and inhibition of fractalkine protein as inhibitor of RSV‐induced autophagy (Xuan et al., 2012).…”

Section: Resveratrol and Diseasesmentioning

confidence: 99%

Resveratrol: A miraculous natural compound for diseases treatment

Koushki

Amiri-Dashatan

Ahmadi

et al. 2018

Food Science & Nutrition

210

109

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Resveratrol (3, 5, 4′‐trihydroxystilbene) is a nonflavonoid polyphenol that naturally occurs as phytoalexin. It is produced by plant sources such as grapes, apples, blueberries, plums, and peanut. This compound has critical roles in human health and is well known for its diverse biological activities such as antioxidant and anti‐inflammatory properties. Nowadays, due to rising incidence of different diseases such as cancer and diabetes, efforts to find novel and effective disease‐protective agents have led to the identification of plant‐derived compounds such as resveratrol. Furthermore, several in vitro and in vivo studies have revealed the effectiveness of resveratrol in various diseases such as diabetes mellitus, cardiovascular disease, metabolic syndrome, obesity, inflammatory, neurodegenerative, and age‐related diseases. This review presents an overview of currently available studies on preventive properties and essential molecular mechanisms involved in various diseases.

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“…For example, significant reduction in total cholesterol, systolic blood pressure, diastolic blood pressure, glucose, and insulin have been shown in obese subjects taking 300 mg or more of resveratrol per day [14]. There is also some evidence to suggest resveratrol may have therapeutic potential for management of congestive heart failure [15].…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Potential of Resveratrol for Cardiovascular Protection

Yeung¹

2017

Cardiovasc Pharm Open Access

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Potential of resveratrol in the treatment of heart failure

Cited by 98 publications

References 102 publications

Resveratrol shows neuronal and vascular-protective effects in older, obese, streptozotocin-induced diabetic rats

Resveratrol shows neuronal and vascular-protective effects in older, obese, streptozotocin-induced diabetic rats

Resveratrol: A miraculous natural compound for diseases treatment

Therapeutic Potential of Resveratrol for Cardiovascular Protection

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