Potential of Sustained Release Microparticles of Metformin in Veterinary Medicine: An in Vivo Pharmacokinetic Study of Metformin Microparticles as Oral Sustained Release Formulation in Rabbits.

Bouriche, Sihem; Alonso-García, Angela; Cárceles-Rodríguez, Carlos M.; Rezgui, Farouk; Fernández-Varón, Emilio

doi:10.21203/rs.3.rs-80177/v1

Cited by 2 publications

(1 citation statement)

References 23 publications

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“…The results show that the obtained microparticles have optimal physicochemical characteristics and allow for the prolonged/sustained release expected for metformin, which makes them potentially suitable for diabetes treatment in animals [ 174 ]. Curcumin-nisin-based PLA nanoparticles were also successfully tested for cardioprotection in guinea pigs with induced myocardial infarction [ 175 ].…”

Section: Application Of Biodegradable Polymers In Veterinary Medicinementioning

confidence: 99%

Biodegradable Polymers in Veterinary Medicine—A Review

Broda,

Yelle,

Serwańska-Leja

2024

Molecules

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During the past two decades, tremendous progress has been made in the development of biodegradable polymeric materials for various industrial applications, including human and veterinary medicine. They are promising alternatives to commonly used non-degradable polymers to combat the global plastic waste crisis. Among biodegradable polymers used, or potentially applicable to, veterinary medicine are natural polysaccharides, such as chitin, chitosan, and cellulose as well as various polyesters, including poly(ε-caprolactone), polylactic acid, poly(lactic-co-glycolic acid), and polyhydroxyalkanoates produced by bacteria. They can be used as implants, drug carriers, or biomaterials in tissue engineering and wound management. Their use in veterinary practice depends on their biocompatibility, inertness to living tissue, mechanical resistance, and sorption characteristics. They must be designed specifically to fit their purpose, whether it be: (1) facilitating new tissue growth and allowing for controlled interactions with living cells or cell-growth factors, (2) having mechanical properties that address functionality when applied as implants, or (3) having controlled degradability to deliver drugs to their targeted location when applied as drug-delivery vehicles. This paper aims to present recent developments in the research on biodegradable polymers in veterinary medicine and highlight the challenges and future perspectives in this area.

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Section: Application Of Biodegradable Polymers In Veterinary Medicinementioning

confidence: 99%

Biodegradable Polymers in Veterinary Medicine—A Review

Broda,

Yelle,

Serwańska-Leja

2024

Molecules

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Meta-Assessment of Metformin Absorption and Disposition Pharmacokinetics in Nine Species

Jeong

Jusko

2021

Pharmaceuticals

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The objective of this study was to systematically assess literature datasets and quantitatively analyze metformin PK in plasma and some tissues of nine species. The pharmacokinetic (PK) parameters and profiles of metformin in nine species were collected from the literature. Based on a simple allometric scaling, the systemic clearances (CL) of metformin in these species highly correlate with body weight (BW) (R2 = 0.85) and are comparable to renal plasma flow in most species except for rabbit and cat. Reported volumes of distribution (VSS) varied appreciably (0.32 to 10.1 L/kg) among species. Using the physiological and anatomical variables for each species, a minimal physiologically based pharmacokinetic (mPBPK) model consisting of blood and two tissue compartments (Tissues 1 and 2) was used for modeling metformin PK in the nine species. Permeability-limited distribution (low fd1 and fd2) and a single tissue-to-plasma partition coefficient (Kp) value for Tissues 1 and 2 were applied in the joint mPBPK fitting. Nonlinear regression analysis for common tissue distribution parameters along with species-specific CL values reasonably captured the plasma PK profiles of metformin across most species, except for rat and horse with later time deviations. In separate fittings of the mPBPK model to each species, Tissue 2 was considered as slowly-equilibrating compartment consisting of muscle and skin based on in silico calculations of the mean transit times through tissues. The well-fitted mPBPK model parameters for absorption and disposition PK of metformin for each species were compared with in vitro/in vivo results found in the literature with regard to the physiological details and physicochemical properties of metformin. Bioavailability and absorption rates decreased with the increased BW among the species. Tissues such as muscle dominate metformin distribution with low permeability and partitioning while actual tissue concentrations found in rats and mice show likely transporter-mediated uptake in liver, kidney, and gastrointestinal tissues. Metformin has diverse pharmacologic actions, and this assessment revealed allometric relationships in its absorption and renal clearance but considerable variability in actual and modeled tissue distribution probably caused by transporter differences.

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Potential of Sustained Release Microparticles of Metformin in Veterinary Medicine: An in Vivo Pharmacokinetic Study of Metformin Microparticles as Oral Sustained Release Formulation in Rabbits.

Cited by 2 publications

References 23 publications

Biodegradable Polymers in Veterinary Medicine—A Review

Biodegradable Polymers in Veterinary Medicine—A Review

Meta-Assessment of Metformin Absorption and Disposition Pharmacokinetics in Nine Species

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