Potential of Therapeutic Curculigo latifolia Extracts on Alloxan-induced Diabetes in a Male Mus muscullus

Haryanto, Haryanto; Sutandi, Agus; Kusumawati, Eni; Nurhayati, Sari; Fitri, Fadillya Maulidilla; Nafsi, Ginan; Nuraeni, Sri Wahyuni

doi:10.15294/biosaintifika.v15i3.40498

Cited by 3 publications

(2 citation statements)

References 26 publications

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“…They are usually ovoid and long-beaked, with small black seeds. 13,33 34 35 Nur, Setiawan, et al (2023a), 36 Umar et al (2023), 37 Umar et al (2021a) 38 , and Umar et al (2021b) 39 ).…”

Section: Morphology Of Curculigo Latifoliamentioning

confidence: 98%

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A review on the phytochemistry and biological activities of Curculigo latifolia Dryand ex. W.Aiton

Taufik,

Mohd Yasin,

Ahmad

et al. 2024

F1000Res

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Curculigo latifolia Dryand. ex W. T. Aiton, from the genus Curculigo, is a medicinal plant traditionally used to treat numerous illnesses such as fever, stomach aches, jaundice, wounds, and inflammation. C. latifolia is a perennial herb that is widely found in tropical and subtropical regions, such as Southeast Asia, Southern China, Bangladesh, Australia, and the Andaman Islands. This review collates the reported studies on the different aspects of C. latifolia from its plant description, nutritional value, phytochemistry, chemical composition, and pharmacological properties. This review aims to identify gaps in the literature and provide useful references for future work on this plant. Previous studies have shown that C. latifolia contains high mineral contents of calcium, iron, and magnesium, which are essential components of human health. Moreover, the plant is rich in phytochemicals, which play a prominent role in various pharmacological activities. The most common compounds identified included curculigoside, crassifoside I, nyasicoside, and curculigine. C. latifolia demonstrated high antioxidant activity through its ability to scavenge superoxide anions, 1,1–diphenyl–2–picrylhydrazyl (DPPH) and 2,2’-azino–bis(3–ethylbenzthiazoline–6–sulfonic acid) (ABTS) radicals, reducing ferric ions to ferrous complexes, iron chelation, and B-carotene bleaching. It was also shown that the roots, stems, and leaves of C. latifolia were effective in exerting antimicrobial activity against several microbial strains, including Bacillus cereus, Bacillus subtillis, Enterobacter aerogenes, Erwinia sp., Klebsiella sp., Pseudomonas sp., Candida albicans, Salmonella choleraesuis and Staphylococcus aureus. Moreover, the root, fruit, leaf, petiole, and rhizome extracts were found to improve glucose uptake and insulin secretion in diabetic rats, suggesting their antidiabetic potential. C. latifolia presents a wide range of medicinal properties that could make it a promising functional food or source of food supplements to prevent nutrition–related or chronic diseases.

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“…They are usually ovoid and long-beaked, with small black seeds. 13,33 34 35 Nur, Setiawan, et al (2023a), 36 Umar et al (2023), 37 Umar et al (2021a) 38 , and Umar et al (2021b) 39 ).…”

Section: Morphology Of Curculigo Latifoliamentioning

confidence: 98%

“…Different parts of Curculigo latifolia. (a) whole plant, (b) leaves, (c) petiole/stem, (d) roots, (e) callus, (f) plantlet leaves, (g) fruits, (h) flowers, (I) rhizomes (Images retrieved from Babaei et al (2014),34 Haryanto et al (2023),35 Nur, Setiawan, et al (2023a),36 Umar et al (2023),37 Umar et al (2021a)38 , and Umar et al (2021b)39 ).…”

mentioning

confidence: 99%

A review on the phytochemistry and biological activities of Curculigo latifolia Dryand ex. W.Aiton

Taufik,

Mohd Yasin,

Ahmad

et al. 2024

F1000Res

View full text Add to dashboard Cite

show abstract

A review on the phytochemistry and biological activities of Curculigo latifolia Dryand ex. W.Aiton

Taufik,

Mohd Yasin,

Ahmad

et al. 2024

F1000Res

View full text Add to dashboard Cite

Curculigo latifolia Dryand. ex W. T. Aiton, from the genus Curculigo, is a medicinal plant traditionally used to treat numerous illnesses such as fever, stomach aches, jaundice, wounds, and inflammation. C. latifolia is a perennial herb that is widely found in tropical and subtropical regions, such as Southeast Asia, Southern China, Bangladesh, Australia, and the Andaman Islands. This review collates the reported studies on the different aspects of C. latifolia from its plant description, nutritional value, phytochemistry, chemical composition, and pharmacological properties. This review aims to identify gaps in the literature and provide useful references for future work on this plant. Previous studies have shown that C. latifolia contains high mineral contents of calcium, iron, and magnesium, which are essential components of human health. Moreover, the plant is rich in phytochemicals, which play a prominent role in various pharmacological activities. The most common compounds identified included curculigoside, crassifoside I, nyasicoside, and curculigine. C. latifolia demonstrated high antioxidant activity through its ability to scavenge superoxide anions, 1,1–diphenyl–2–picrylhydrazyl (DPPH) and 2,2’-azino–bis(3–ethylbenzthiazoline–6–sulfonic acid) (ABTS) radicals, reducing ferric ions to ferrous complexes, iron chelation, and β –carotene bleaching. It was also shown that the roots, stems, and leaves of C. latifolia were effective in exerting antimicrobial activity against several microbial strains, including Bacillus cereus, Bacillus subtillis, Enterobacter aerogenes, Erwinia sp., Klebsiella sp., Pseudomonas sp., Candida albicans, Salmonella choleraesuis and Staphylococcus aureus. Moreover, the root, fruit, leaf, petiole, and rhizome extracts were found to improve glucose uptake and insulin secretion in diabetic rats, suggesting their antidiabetic potential. C. latifolia presents a wide range of medicinal properties that could make it a promising functional food or source of food supplements to prevent nutrition–related or chronic diseases.

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Antidiabetic Activity Test of Fe(III) Complex Compound with Arginine Ligand in Male Mice (Mus Musculus L.)

Ambarwati,

Nurhasanah,

Karima

et al. 2024

J. Multidiscip. Appl. Nat. Sci.

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Diabetes mellitus is characterized by high blood sugar levels in the body. Treatment for type 1 diabetes mellitus is with insulin injections while treatment for type 2 diabetes mellitus generally uses oral medication. Currently, people are looking for diabetes drugs made from complex compounds using metals. The development of research and utilization of Fe(III) complex compounds is still limited, thus, in this study the synthesis of Fe(III) complex compounds with arginine ligands was carried out. The results of the research obtained a complex compound of Fe(III)-arginine with 96%, in the form of a brown gel with a sample weight of 0.5601 g. Characterization using a UV-Vis spectrophotometer showed absorption at a wavelength of 203 nm which indicated the absorption of the Fe(III)-arginine complex. The results of FTIR analysis showed a typical absorption of Fe–O and Fe–N bonds at a wavelength of 500–600 nm. The results of the calculation of the mice's body weight decreased when induced by alloxan. After 3 and 4 weeks, the mice's body weight returned to stability. The highest decrease in glucose levels was in dose 2, namely 100 μg/kg bw with a decrease in %GL of 66.72%. The results of this study show that the complex compound Fe(III) arginine can reduce blood glucose levels in mice.

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Potential of Therapeutic Curculigo latifolia Extracts on Alloxan-induced Diabetes in a Male Mus muscullus

Cited by 3 publications

References 26 publications

A review on the phytochemistry and biological activities of Curculigo latifolia Dryand ex. W.Aiton

A review on the phytochemistry and biological activities of Curculigo latifolia Dryand ex. W.Aiton

A review on the phytochemistry and biological activities of Curculigo latifolia Dryand ex. W.Aiton

Antidiabetic Activity Test of Fe(III) Complex Compound with Arginine Ligand in Male Mice (Mus Musculus L.)

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