Potential of traditional ayurvedic formulation, Triphala, as a novel anticancer drug

Sandhya, Tera; Lathika, K. M.; Pandey, Badri N.; Mishra, Kaushala Prasad

doi:10.1016/j.canlet.2005.01.035

Cited by 115 publications

(87 citation statements)

References 17 publications

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“…In addition, gallic acid, a major component of T. bellerica [14,15] has the capacity to induce apoptosis [35] and increase the efficacy of cisplatin in combined treatment of mice transplanted with LL-2 lung cancer cells [36] . These findings suggest that in the synergistic activity of P. emblica or T. bellerica extracts and doxorubicin it seem to be possible that the extracts could induce cytotoxic to tumor cells by a ROS mediated mechanism in cancer cells but less in normal cell [37] as well as inhibit glutathione conjugate export pump as a result, the extracts would increase the sensitivity of A549 and HepG2 cells to doxorubicin and cisplatin. In summary, our results demonstrate that combinations of P. emblica or T. bellerica extracts with doxorubicin or cisplatin in A549 and HepG2 cell lines have a better effect than either agent alone.…”

Section: Discussionmentioning

confidence: 94%

Synergistic growth inhibitory effects of Phyllanthus emblica and Terminalia bellerica extracts with conventional cytotoxic agents: Doxorubicin and cisplatin against human hepatocellular carcinoma and lung cancer cells

Pinmai

Chunlaratthanabhorn²,

Ngamkitidechakul³

et al. 2008

WJG

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AIM:To examine the growth inhibitory effects of Phyllanthus emblica (P. emblica ) and Terminalia bellerica (T. bellerica ) extracts on human hepatocellular carcinoma (HepG2), and lung carcinoma (A549) cells and their synergistic effect with doxorubicin or cisplatin. METHODS:HepG2 and A549 cells were treated with P. emblica and T. bellerica extracts either alone or in combination with doxorubicin or cisplatin and effects on cell growth were determined using the sulforhodamine B (SRB) assay. The isobologram and combination index (CI) method of Chou-Talalay were used to evaluate interactions between plant extracts and drugs. R E S U LT S : P. e m b l i c a a n d T. b e l l e r i c a e x t r a c t s demonstrated growth inhibitory activity, with a certain degree of selectivity against the two cancer cell lines tested. Synergistic effects (CI < 1) for P. emblica / doxorubicin or cisplatin at different dose levels were demonstrated in A549 and HepG2 cells. The T. bellerica / cisplatin or doxorubicin also showed synergistic effects in A549 and HepG2 cells. In some instances, the combinations resulted in antagonistic effects. The dose reduction level was different and specific to each combination and cell line. CONCLUSION:The growth inhibitory activity of doxorubicin or cisplatin, as a single agent, may be modified by combinations of P. emblica or T. bellerica extracts and be synergistically enhanced in some cases. Depending on the combination ratio, the doses for each drug for a given degree of effect in the combination may be reduced. The mechanisms involved in this interaction between chemotherapeutic drugs and plant extracts remain unclear and should be further evaluated.

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Section: Discussionmentioning

confidence: 94%

Synergistic growth inhibitory effects of Phyllanthus emblica and Terminalia bellerica extracts with conventional cytotoxic agents: Doxorubicin and cisplatin against human hepatocellular carcinoma and lung cancer cells

Pinmai

Chunlaratthanabhorn²,

Ngamkitidechakul³

et al. 2008

WJG

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“…Triphala recipe possesses many biological activities including antimutagenic (Kaur et al, 2002), radioprotective (Sandhya et al, 2006a), hypocholesterolaemic (Saravanan et al, 2007), immunomodulatory (Srikumar et al, 2005), anticancer (Deep et Sandhya et al, 2006b), and anti-oxidant activities (Naik et al, 2005). Moreover, this recipe has an anti-inflammatory activity on adjuvant-induced arthritis in mice (Rasool and Sabina, 2007).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of anti-inflammatory and antinociceptive activity of Triphala recipe

Sireeratawong¹,

Jaijoy²,

Soonthornchareonnon³

2013

Afr. J. Trad. Compl. Alt. Med.

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The anti-inflammatory and antinociceptive activities of Triphala recipe were studied in animal models. Triphala recipe (4 mg/ear) significantly exhibited an inhibitory effect on the ear edema formation induced by ethyl phenylpropiolateinduced, but not on the arachidonic acid -induced ear edema in rats. Furthermore, Triphala recipe at the doses of 300, 600 and 1,200 mg/kg significantly reduced carrageenan-induced hind paw edema. Next, the anti-inflammatory action in chronic inflammation was measured using the cotton pellet-induced granuloma formation assay in rats. Triphala recipe (1,200 mg/kg) reduced neither transudative weight nor granuloma formation. It also did not affect on body weight gain and thymus weight indicating that Triphala recipe does not have a steroid-like effect. In antinociceptive study, Triphala recipe (300, 600, 1,200 mg/kg), elicited significant inhibitory effect on both phases, especially in late phase, of the formalin test in mice suggesting that the antinociceptive action of Triphala recipe may be via both peripheral and at least partly centrally acting.

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“…16 Conversely, the cytotoxic effects of Triphala are negligible in normal cell lines. 13,14 T. belliricia extracts have also demonstrated growth inhibitory effects towards human A549 lung cancer cell lines and HepG2 hepatocarcinoma cell lines without the presence of the other plant components present in Triphala. 17 T. belliricia extracts also have synergistic effects with conventional anticancer chemotherapeutics, enhancing the cytotoxic activity of cisplatin and doxorubicin towards the cancer cell lines, indicating their potential as synergistic cancer chemotherapeutic agents.…”

Section: Introductionmentioning

confidence: 99%

“…have been reported to have potent anticancer properties. The Ayurvedic medicine Triphala (which contains Terminalia belliricia and Terminalia chebula) has cytotoxic effects against thymic lymphoma cells, 13,14 human breast cancer cell lines, 13,15 human prostate cancer cell lines and human pancreatic cancer cell lines. 16 Conversely, the cytotoxic effects of Triphala are negligible in normal cell lines.…”

Section: Introductionmentioning

confidence: 99%

Inhibition of Caco-2 and HeLa proliferation by Terminalia carpentariae C. T. White and Terminalia grandiflora Benth. extracts: Identification of triterpenoid components

Courtney¹,

Sirdaarta²,

White³

et al. 2017

Phcog J

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Background: Terminalia spp. are characterised by their high antioxidant capacities and many have anticancer activity. This study examines the anti-proliferative activity of T. carpentariae leaf and T. grandiflora leaf, fruit and nut extracts against Caco-2 and HeLa carcinoma proliferation. Materials and Methods: Powdered T. carpentariae leaf and T. grandiflora leaf, fruit and nut were extracted and tested for anti-proliferative activity against Caco-2 and HeLa cancer cell lines using colorimetric cell proliferation assays. Toxicity was evaluated using an Artemia franciscana nauplii bioassay. The extract with the most potent anti-proliferative activity was examined using GC-MS analysis and triterpenoid compounds were identified by comparison with a compound database. Results: T. carpentariae leaf and T. grandiflora leaf, fruit and nut extracts displayed potent anti-proliferative activity against Caco-2 and HeLa carcinoma cells. The methanolic T. grandiflora leaf extract was particularly effective at blocking the proliferation of the colorectal carcinoma Caco-2 (IC 50 = 372 µg/mL). The methanol T. carpentariae and T. grandiflora leaf extracts were similarly potent inhibitors of HeLa cervical cancer cell proliferation with IC50 values of 864 and 833 µg/mL respectively. The methanolic T. grandiflora fruit and nut extracts, as well as all aqueous and ethyl acetate extracts, were moderate to good inhibitors of carcinoma proliferation. In contrast, chloroform and hexane extracts were generally devoid of anti-proliferative activity. The methanolic T. grandiflora extracts displayed low toxicity in the Artemia nauplii bioassay. All other extracts were non-toxic. GC-MS analysis of the methanolic T. grandiflora leaf extract identified 3 lanostane and 2 pentacyclic triterpenoids. Conclusion: The low toxicity and anti-proliferative activity observed with the T. carpentariae and T. grandiflora extracts against Caco-2 and HeLa indicate their potential for the prevention and treatment of some cancers.

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Potential of traditional ayurvedic formulation, Triphala, as a novel anticancer drug

Cited by 115 publications

References 17 publications

Synergistic growth inhibitory effects of Phyllanthus emblica and Terminalia bellerica extracts with conventional cytotoxic agents: Doxorubicin and cisplatin against human hepatocellular carcinoma and lung cancer cells

Synergistic growth inhibitory effects of Phyllanthus emblica and Terminalia bellerica extracts with conventional cytotoxic agents: Doxorubicin and cisplatin against human hepatocellular carcinoma and lung cancer cells

Evaluation of anti-inflammatory and antinociceptive activity of Triphala recipe

Inhibition of Caco-2 and HeLa proliferation by Terminalia carpentariae C. T. White and Terminalia grandiflora Benth. extracts: Identification of triterpenoid components

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