Potential of uniaxial electrospun composite nanofibers based on polycaprolactone and polyvinyl alcohol in guided bone regeneration

Abstract

Polycaprolactone and polyvinyl alcohol are commonly used polymers with biocompatibility and biodegradability. However, the poor mechanical properties of polycaprolactone and the high swelling properties of polyvinyl alcohol hinder their application in guided tissue/bone regeneration. In this study, a new strategy for preparing absorbable guided bone regeneration (GBR) membrane was innovatively put forward, which was to simply blend them in formic acid in different proportions (0%/100%, 25%/75%, 50%/50%, 75%/25%, and 100%/0% wt/wt) and obtain nanofiber membrane by uniaxial electrospinning. The nano‐structure was confirmed by scanning electron microscope, and the change of chemical functional groups was confirmed by Fourier transform infrared spectroscopy. In addition, the proper polymer proportion (75%/25%) was selected through some tests. The results show that the nanofiber membrane has suitable wettability (104.083 ± 2.512°), sufficient Young's modulus (90.895 ± 7.431 MPa), the lowest swelling rate (33.705 ± 1.806%) and shrinkage rate (1.878 ± 3.252%), and no cytotoxicity. Its biodegradability and osteogenic effects in vitro were also investigated to show the potential applied in GBR.

Piezoelectric performance of co-axial electrospun PVDF/TPU nanofiber mats

“…Oriented nanofiber bundles and nanofiber thread have significant value in many application areas, including filters [3][4][5][6][7], sensors [8-10],biomedical materials [11-13], tissue engineering scaffolds [14-17], drug delivery [14,[18][19][20][21], and wound dressings [22][23][24][25][26], nanogenerators [8,[27][28][29][30][31][32][33][34][35][36]. Issues such as the simplicity of the mechanism to be used, the ability to easily change the process parameters, and the wide choice of polymers to be used have made this method a common practice today and enable multiaxial electrospinning [8,[37][38][39].PVDF/TPU core-shell nanofiber electrospun piezoelectric mats have garnered significant attention in the field of flexible and wearable electronics due to their exceptional piezoelectric properties and mechanical flexibility.Polyvinylidene fluoride (PVDF) and thermoplastic polyurethane (TPU) are combined to form a unique core-shell structure, where the PVDF core provides excellent piezoelectric response, while the TPU shell enhances the mechanical robustness and flexibility of the nanofiber mat. The piezoelectric effect allows these mats to generate electrical charges in response to mechanical stress.…”

“…biomedical materials [11-13], tissue engineering scaffolds [14-17], drug delivery [14,[18][19][20][21], and wound dressings [22][23][24][25][26], nanogenerators [8,[27][28][29][30][31][32][33][34][35][36]. Issues such as the simplicity of the mechanism to be used, the ability to easily change the process parameters, and the wide choice of polymers to be used have made this method a common practice today and enable multiaxial electrospinning [8,[37][38][39].…”