Potential of wild plant Artemisia judaica L. as sustainable source of antioxidant and antimicrobial compounds

Abstract

Artemisia judaica L. (Shih Balady, family Asteraceae), is a medicinal plant that grows in the desert, commonly used as tea by population in Egypt Sinai and of Saudi Arabia. The present study aims to evaluate antimicrobial and antioxidant activities of aerial parts of A. judaica collected from the inland desert (Wadi Hagoul) of Egypt. Total phenolics, tannins, alkaloids, flavonoids, and saponins were measured in the plant of interest. According to the reduction of DPPH the anti-oxidant activity was measured. Different extracts of A. judaica were screened for their antimicrobial activity against nine pathogenic microorganisms using filter paper disc assay. The secondary metabolites of A. judaica were examined and proved that it was rich in tannins and phenolics (13.29 and 7.62 mg/g dw). The IC50 values of A. judaica extract was 1.78 mg.ml-1 compared to standard catechol (0.15 mg.ml-1). In the present study, the extracts of A. judaica showed unusual activity depending on the type of bacteria and fungi. Also, ethyl acetate and methyl alcohol extracts showed considerable broad spectrum (77.78%, each) against both bacteria and fungi, followed by acetone, then methylene chloride and petroleum ether extracts. This study showed that A. judaica extracts could be used as antimicrobial substances in pharmaceutical and food preservation systems.

Phytochemical Characterization and Efficacy of Artemisia judaica Extract Loaded Chitosan Nanoparticles as Inhibitors of Cancer Proliferation and Microbial Growth

“…Artemisia judaica L. is one of the important species of Artemisia commonly grown in the Mediterranean area, including Saudi Arabia, Egypt, Algeria, Libya, and Jordan [ 6 ]. A. judaica was reported to exhibit great potential therapeutic use for gastrointestinal disorders, inflammatory disorders, sexual dysfunction, heart diseases, hyperglycemia, cancers, arthritis, oxidative stress, and wound healing [ 7 , 8 ].…”

Bio-Evaluation of the Wound Healing Activity of Artemisia judaica L. as Part of the Plant’s Use in Traditional Medicine; Phytochemical, Antioxidant, Anti-Inflammatory, and Antibiofilm Properties of the Plant’s Essential Oils

“…Artemisia judaica L. (ArJ) is widely grown in the Mediterranean region, including Algeria, Libya, Egypt, Jordan, and Saudi Arabia [ 16 , 17 , 18 , 19 , 20 ]. In Saudi Arabia, ArJ grows in the kingdom’s northern region, including the border area of the Hail-Qassim regions [ 21 ].…”

“…In addition, ArJ is traditionally used to treat gastrointestinal disorders, sexual inability, hyperglycemia, heart diseases, inflammatory disorders, arthritis, cancers [ 1 , 20 ], skin diseases, atherosclerosis, and enhance vision and immunity [ 23 , 24 ]. The Bedouins in Egypt (Sinai) and Saudi Arabia also use the plant as a herbal tea in treating GIT disorders [ 16 ]. Biologically, ArJ demonstrated antidiabetic, antioxidant, hepatoprotective, and anti-inflammatory activities in experimental animals [ 22 , 25 , 26 ] due to the properties inherent in the chemical structure of the compounds it contains [ 27 ].…”

Extraction development for antimicrobial and phytotoxic essential oils from asteraceae species: Achillea fragrantissima, Artemisia judaica and Tanacetum sinaicum

“…The species is used in folk medicine for a number of remedies including cold, gastrointestinal cramps, stomach upset, abdominal disturbances and constipation 30 . Volatile oil of A judaica has antimicrobial and antioxidant activity, 31 and it is also used in the treatment of inflammatory‐related diseases, fungal infections, 32 diabetes 33 and cancer 34 . Tanacetum sinaicum , locally known as ‘Elmear’, is a wild rocky plant with yellow heads woolly leaves 35 .…”