Potential of β-carotene as anti-aging serum: A narrative review

Rahmah, Nadhiya Nurfitra; Tama, Nabilla Dira; Wulandari, Nenis Rahma; Nurcholis, Waras

doi:10.26452/ijrps.v12i3.4807

Cited by 4 publications

(1 citation statement)

References 14 publications

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“…[33] The high antioxidant activity of β-carotene has potential as an anti-aging agent according to previous research. [34] The forms of vitamin E present in PFLO, including αtocopherol, γtocopherol, and βtocopherol (α-T, γ-T, and β-T) were detected and quantified in PLFO (Table 1). The content of α-T in PLFO was about 957.88 ± 2.12 mg kg -1 , which was much higher than that found by Wissal et al [35] (759 mg kg -1 ).…”

Section: Tocopherol and Carotenoid Contentsmentioning

confidence: 99%

Phytochemical profile of Tunisian Pistacia lentiscus fruits oil: Antioxidant, antiplatelet, and cytotoxic activities assessment

Ameur,

Hadjkacem,

Ayadi

et al. 2024

Euro J Lipid Sci & Tech

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This study aims to comprehensively examine the chemical composition, physicochemical characterization, as well as antioxidant and antiplatelet activities of Pistacia lentiscus fruit oil (PLFO). Our results showed that the prominent class of fatty acids was represented by monounsaturated fatty acids (42.73%), followed by saturated fatty acids (33.99%) and polyunsaturated fatty acids (23.13%). The different ratios of fatty acids were determined (PUFA/MUFA = 0.54, PUFA/SAFA = 0.68 and MUFA/SAFA = 1.25). The obtained results related to saturated and polysaturated fatty acids ratios were in line with the recommendations of the World Health Organization (WHO). The principal fatty acid (FA) consisted in oleic acid (41.32%), followed by linoleic acid (23.08%). A comparison was made with Moroccan and Algerian PLFO showing that Tunisian PLFO is the richest in linoleic acid. The main tentatively identified triacylglycerols, which are in monounsaturated and polyunsaturated forms, were SLL+PLO (19.73%), OOL+LnPP (13.12%) and POO (10.57%). The primary sterol identified in PLFO was β‐sitosterol (80.19%). However, tocopherols were quantified at a content of 1249.16 mg g–1 of oil. The effect on platelet aggregation was evaluated on human platelet‐rich plasma treated with various PLFO concentrations, dissolved in ethanol (named POE) and then induced by ADP, collagen, and arachidonic acid (AA). The outcome revealed that 8 µL mL–1 of POE strongly inhibited ADP‐induced platelet aggregation in humans. Additionally, the expression of CD63 and P‐selectin as markers of platelet secretion, and αΙΙβ3 integrin activation were assessed by flow cytometry. It has been found that PLFO significantly reduced platelet activation as well as alpha and dense granule secretion. Moreover, the cytotoxicity assay on normal HEK‐293 cells, the hemolysis test and the platelet viability confirmed that PLFO is a safe substance. These findings are valuable for assessing the nutritional composition of PLFO within a preventive and/or therapeutic framework in a clinical context.Practical applications: PLFO is mainly used to alleviate problems related to poor blood circulation, especially for women but it is also employed to treat problems such as heavy legs and varicose veins. Furthermore, PLFO would prevent certain diseases such as phlebitis, and alleviates various disorders, including cardiovascular problems.

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Section: Tocopherol and Carotenoid Contentsmentioning

confidence: 99%

Phytochemical profile of Tunisian Pistacia lentiscus fruits oil: Antioxidant, antiplatelet, and cytotoxic activities assessment

Ameur,

Hadjkacem,

Ayadi

et al. 2024

Euro J Lipid Sci & Tech

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Discovering the direct relations between nutrients and epigenetic ageing

Grootswagers,

Bach,

Biemans

et al. 2024

The Journal of nutrition, health and aging

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An Updated Review on the Role of Phytoconstituents in Modulating Signalling Pathways to Combat Skin Ageing: Nature’s Own Weapons and Approaches

Porwal,

Rastogi,

Chandra

et al. 2024

NPJ

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Various geographical areas exhibit varying degrees of prevalence and severity of dermatological issues. The most commonly observed skin issues among adolescents during their growth period on a global scale encompass dry skin, dyspigmentation, wrinkles, fungal infections, as well as benign and malignant tumors. These conditions arise as a consequence of diminished functional capacity and heightened skin susceptibility. The primary manifestation of the whole process of skin ageing is its visual presentation, which encompasses changes in both the structure and function of the skin. The look and function of human skin exhibit particular variations as individuals age, representing a time-dependent phenomenon. This review article primarily examines the discussion surrounding the diverse phytoconstituents and their impact on signalling pathways in cellular metabolism, as well as their interaction with environmental factors and xenobiotic agents that contribute to skin aging. Ultraviolet (UV) light induces the rapid formation and subsequent accumulation of reactive oxygen species (ROS) within skin cells, hence accelerating oxidative stress and the ageing process of the skin. One effective approach to addressing age-related skin disorders entails the utilization of exogenous supplementation through the consumption of dietary antioxidants, as well as the application of antioxidant-based lotions to the skin prior to sun exposure. Several plant species include phenolic components, including ascorbic acid, ellagitannins, and carotenoids, which have the ability to protect the skin from harmful UV radiation, reduce inflammation and oxidative stress, and influence several survival signalling pathways. This comprehensive study elucidated multiple processes by which phytoconstituents exert their effects for intervention purposes. Additionally, it highlighted the ability of these phytoconstituents to modulate the NF-κB signalling pathway, MAPK signalling, Nrf2 signalling, and other pathways, hence demonstrating their potential anti-aging properties.

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Potential of β-carotene as anti-aging serum: A narrative review

Cited by 4 publications

References 14 publications

Phytochemical profile of Tunisian Pistacia lentiscus fruits oil: Antioxidant, antiplatelet, and cytotoxic activities assessment

Phytochemical profile of Tunisian Pistacia lentiscus fruits oil: Antioxidant, antiplatelet, and cytotoxic activities assessment

Discovering the direct relations between nutrients and epigenetic ageing

An Updated Review on the Role of Phytoconstituents in Modulating Signalling Pathways to Combat Skin Ageing: Nature’s Own Weapons and Approaches

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