Potential Oral Health Benefits of Ginseng and Its Extracts

Peng, Yuqing; Pan, Wenting; Cao, Xianlong; Liu, C.

doi:10.1016/j.identj.2023.02.004

Cited by 7 publications

(4 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PPDs and PPTs represent the predominant ginsenoside groups distinguished by the position of the sugar molecule. While the PPD group has a sugar molecule attached to C-3 and/or C-20 of sapogenin to form an oxyglycoside, the PPT group has a sugar molecule attached to C-6 and/or C-20 of sapogenin to form an oxyglycoside [ 6 ] ( Figure 3 ).…”

Section: Panax Ginseng and Ginsenosidementioning

confidence: 99%

“…Studies directed at treating bone-destructive diseases typically assess parameters such as osteoblast proliferation and activity, osteoclast production and resorption, and inflammatory responses implicated in bone degradation [ 4 , 5 ]. Evaluation often extends to the measurement of anti-inflammatory, antioxidant, and anti-pyroptotic activities, as well as the inhibition of extracellular matrix degradation [ 5 , 6 , 7 ]. Analyses of nuclear factor kappa-κB (NF-κB) and mitogen-activated protein kinase (MAPK) expression and activity in relevant cells serve to elucidate the signaling pathways involved [ 8 , 9 , 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Therapeutic Potential of Ginsenosides on Bone Metabolism: A Review of Osteoporosis, Periodontal Disease and Osteoarthritis

2024

IJMS

View full text Add to dashboard Cite

Ginsenosides, bioactive compounds from the genus Panax, have potential therapeutic effects on diverse ailments, including diabetes. Emerging evidence suggests their involvement in bone metabolism. The present review summarizes the current understanding of the effects of ginsenosides on osteoporosis, periodontal disease, and osteoarthritis. Their mechanisms of action include effects on osteoblasts, osteoclasts, periodontal ligament fibroblasts (PDLFs), and chondrocytes, which are pivotal in maintaining bone, periodontal tissue, and cartilage homeostasis. Ginsenosides may exert their beneficial effects by enhancing PDLF and osteoblast activity, suppressing osteoclast function, augmenting chondrocyte synthesis in the cartilage matrix, and mitigating connective tissue degradation. Moreover, they possess antioxidant, anti-inflammatory, antimicrobial, and anti-pyroptotic properties. Their efficacy in increasing bone density, ameliorating periodontitis, and alleviating osteoarthritis symptoms has been demonstrated in preclinical studies using animal models. In terms of their mechanism of action, ginsenosides modulate cellular differentiation, activity, and key signaling pathway molecules, such as mitogen-activated protein kinases (MAPKs), while also regulating various mediators. Furthermore, the symptomatic relief observed in animal models lends further credence to their therapeutic utility. However, to translate these preclinical findings into clinical practice, rigorous animal and clinical investigations are imperative to ascertain the safety, efficacy, and optimal dosing regimens in human subjects.

show abstract

Section: Panax Ginseng and Ginsenosidementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Therapeutic Potential of Ginsenosides on Bone Metabolism: A Review of Osteoporosis, Periodontal Disease and Osteoarthritis

2024

IJMS

View full text Add to dashboard Cite

show abstract

“…Phytogenic such as wild ginseng ( WG ) contains bioactive compounds which include ginseng saponin ( GS ), lignans, peptides, polyacetylenes, and alkaloids, making it a potent source of traditional medications for centuries in the Eastern part of Asia due to its multifaceted immune and energy boosting ability with anti-oxidative and anti-inflammatory capacity ( Yan et al, 2011 ; Peng et al, 2023 ). This antioxidant and anti-inflammatory activity is vital for cellular health and may contribute to ginseng's reported anti-aging effects, and has been proven to improve performance ( Su et al, 2023 ; Tajudeen et al, 2023 ).…”

Section: Introductionmentioning

confidence: 99%

The pharmaceutical effect of Korean wild ginseng residue extract on the performance, microbiota quality, cytokine expression, and the ginseng saponin content of laying hen

Tajudeen,

Ha,

Hosseindoust

et al. 2024

Poultry Science

View full text Add to dashboard Cite

“…Meyer is a natural product that is extensively used in Korea, China, and Japan [ 10 ]. It is composed of major saponins and non-saponins, with ginsenosides being a major component of the saponin group, whereas polysaccharides, proteins, peptides, and gintonins (GTs) belong to the non-saponin group [ 11 ]. Among them, GT is a glycolipoprotein fraction of ginseng and is composed of carbohydrates as the main ingredient, lipids, and proteins containing several hydrophobic and acidic amino acids, as well as glucose [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Gintonin Isolated from Ginseng Inhibits the Epithelial—Mesenchymal Transition Induced by TGF-β in A549 Lung Cancer Cells

Kim

Nah

Park

et al. 2023

Plants

View full text Add to dashboard Cite

Epithelial-to-mesenchymal transition (EM transition) is a process wherein epithelial cells lose their intrinsic characteristics and cell–cell junctions and differentiate into a mesenchymal phenotype. EM transition is an important feature of cancer invasion and metastasis. In this study, we aimed to investigate the inhibitory effect of gintonin (GT), an ingredient of ginseng, on EM transition using A549 cells. The proliferation of A549 cells was enhanced following treatment with 50, 75, and 100 μg/mL of GT. GT affected EM transition-induced gene and protein expression, specifically that of vimentin (Vim), N-cadherin (N-cad), zinc finger E-box-binding homeobox 1, and Twist in A549 cells. Furthermore, the transforming growth factor beta 1 (TGF-β1)-induced phosphorylation of Smad2 and Smad3 was suppressed by GT treatment. Immunofluorescence staining also showed that GT treatment decreased the TGF-β1-induced expression of Vim and N-cad in A549 cells. Therefore, GT may be used to suppress cancer cell metastasis via maintenance of the cell–cell junction’s integrity. However, further studies are required to pave the way for its translation into clinical application in cancer therapeutics.

show abstract

Potential Oral Health Benefits of Ginseng and Its Extracts

Cited by 7 publications

References 51 publications

Therapeutic Potential of Ginsenosides on Bone Metabolism: A Review of Osteoporosis, Periodontal Disease and Osteoarthritis

Therapeutic Potential of Ginsenosides on Bone Metabolism: A Review of Osteoporosis, Periodontal Disease and Osteoarthritis

The pharmaceutical effect of Korean wild ginseng residue extract on the performance, microbiota quality, cytokine expression, and the ginseng saponin content of laying hen

Gintonin Isolated from Ginseng Inhibits the Epithelial—Mesenchymal Transition Induced by TGF-β in A549 Lung Cancer Cells

Contact Info

Product

Resources

About