2020
DOI: 10.1097/mao.0000000000002728
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Potential Ototopical Antiseptics for the Treatment of Active Chronic Otitis Media: An In Vitro Evaluation

Abstract: Objectives: Primary: to compare, in vitro, the antimicrobial activity of different antiseptic agents versus quinolone drops, against the common organisms of chronic otitis media. Secondary: to examine the possible role of pH on the antimicrobial activity of the antiseptic solutions. Methods: Three antiseptic powders (boric acid; iodine; and a 1:1 combination of these two) and four solutions (2% boric acid; 2% acetic acid; 3.25% aluminum acet… Show more

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(2 citation statements)
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“…Otitis media (OM), one of the most common infectious diseases, particularly in developing countries, is caused by bacterial or viral pathogens in the middle ear 1,2 . The prevalence in different regions and ethnic groups can range between 0.4% and 46%, and it can be seen in all age groups 3,4 . Chronic OM (COM) is characterized by a perforated tympanic membrane, a persistent discharge from the middle ear, and hearing loss 1,5 .…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…Otitis media (OM), one of the most common infectious diseases, particularly in developing countries, is caused by bacterial or viral pathogens in the middle ear 1,2 . The prevalence in different regions and ethnic groups can range between 0.4% and 46%, and it can be seen in all age groups 3,4 . Chronic OM (COM) is characterized by a perforated tympanic membrane, a persistent discharge from the middle ear, and hearing loss 1,5 .…”
Section: Introductionmentioning
confidence: 99%
“…Due to its mildly acidic nature, the outer ear canal is bacteriostatic in character. Lowering pH in COM may be beneficial to treatment by enhancing this bacteriostatic character 3 . The advantages of topical applications in otology include high concentrations being achieved in the area of application, the fact that no side-effects are caused, and lower bacterial resistance.…”
Section: Introductionmentioning
confidence: 99%