2023
DOI: 10.3390/ijms24076102
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Potential Pathogenic Impact of Cow’s Milk Consumption and Bovine Milk-Derived Exosomal MicroRNAs in Diffuse Large B-Cell Lymphoma

Abstract: Epidemiological evidence supports an association between cow’s milk consumption and the risk of diffuse large B-cell lymphoma (DLBCL), the most common non-Hodgkin lymphoma worldwide. This narrative review intends to elucidate the potential impact of milk-related agents, predominantly milk-derived exosomes (MDEs) and their microRNAs (miRs) in lymphomagenesis. Upregulation of PI3K-AKT-mTORC1 signaling is a common feature of DLBCL. Increased expression of B cell lymphoma 6 (BCL6) and suppression of B lymphocyte-i… Show more

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Cited by 6 publications
(5 citation statements)
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“…Of interest, the levels of miR-148a-3p, the most abundant exosomal miRNA in human and bovine milk, are influenced by diet [65,66], and elevated levels of exosomederived miR-148a-3p have also been characterized in milk from Mediterranean buffalo, Bubalus bubalis, compared to commercial cow milk [8]. Different population studies evaluated the role of the milk-abundant miR-148a-3p in breastfed children's immunity and described the relationship between miR-148a-3p levels and food supplementation [67,68].…”
Section: Discussionmentioning
confidence: 99%
“…Of interest, the levels of miR-148a-3p, the most abundant exosomal miRNA in human and bovine milk, are influenced by diet [65,66], and elevated levels of exosomederived miR-148a-3p have also been characterized in milk from Mediterranean buffalo, Bubalus bubalis, compared to commercial cow milk [8]. Different population studies evaluated the role of the milk-abundant miR-148a-3p in breastfed children's immunity and described the relationship between miR-148a-3p levels and food supplementation [67,68].…”
Section: Discussionmentioning
confidence: 99%
“…In vitro and in vivo studies reported that milk exosome-derived miRNAs also exert oncogenic or oncosuppressor properties ( Figure 2 ). An association has been reported between cow milk consumption and large B-cell lymphoma development, sustained by miR-148a-3p and miR-155-5p/miR-29b-5p increase via let-7-5p/miR-125b-5p [ 44 ]. As oncomir, miR-21 promotes cell growth and anabolism, encouraging cell proliferation and cancer development by activating mTORC1 [ 45 ].…”
Section: Dietary Xenomirnas In Health and Diseasementioning
confidence: 99%
“…In addition, the biological and functional role of dietary miRNAs from different sources in human health is still controversial. Different milk-derived miRNAs have been reported to modulate oncogenic and adipogenic pathways, promoting the development of B-cell lymphoma, hormone-dependent breast and prostate cancer [ 43 , 44 , 45 , 47 ], as well as the ginger-related miRNA has been associated with colitis development [ 64 ] and the pork-derived miRNAs to the development of metabolic disorders in mice [ 22 ]. The evaluation of food-derived xenomiRNA effects cannot refrain from considering the co-existence of a great variety of dietary bioactive compounds.…”
Section: Questions Opening On the Potential Impact Of Dietary Mirnas ...mentioning
confidence: 99%
“…There has been a growing interest in the potential use of mEVs derived from bovine milk for various applications. One promising application is the use of these mEVs for oral drug delivery, particularly for drugs targeting bacterial infections . To this end, our laboratory has successfully obtained large amounts of EVs from bovine milk through various purification techniques .…”
Section: Origin and Function Of Evsmentioning
confidence: 99%