Potential pathological and molecular mechanisms of temporomandibular joint osteoarthritis

Zhang, Juan; Xing-tong, Mu; Zhang, Xu; Li, Changyi

doi:10.1016/j.jds.2023.04.002

Cited by 10 publications

(3 citation statements)

References 110 publications

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“…TMJOA is a chronic degenerative joint disorder, and during this process, condylar flattening is the most common morphological change observed [ 26 ]. Inflammatory response and extracellular matrix degeneration are two typically pathological changes of TMJOA [ 2 ]. β-arrestin2 was reported to play a significant role in various inflammatory diseases [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

“…Temporomandibular joint disorders (TMDs) are a group of conditions that affect the temporomandibular joint (TMJ), masticatory muscles and associated structures [ 1 ]. TMD can be caused by aging, mechanical stress, psychological stress [ 2 ] or autoimmune disease like rheumatoid arthritis [ 3 , 4 ] and SAPHO syndrome [ 5 ]. As one of the most severe subtypes of TMD, temporomandibular joint osteoarthritis (TMJOA) is a chronic degenerative joint disorder characterized by progressive destruction of articular cartilage and subchondral bone resorption [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

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Loss of β-arrestin2 aggravated condylar cartilage degeneration at the early stage of temporomandibular joint osteoarthritis

Zhu,

Huang,

Qin

et al. 2024

BMC Musculoskelet Disord

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Objective Temporomandibular joint osteoarthritis (TMJOA) is a chronic degenerative joint disorder characterized by extracellular matrix degeneration and inflammatory response of condylar cartilage. β-arrestin2 is an important regulator of inflammation response, while its role in TMJOA remains unknown. The objective of this study was to investigate the role of β-arrestin2 in the development of TMJOA at the early stage and the underlying mechanism. Methods A unilateral anterior crossbite (UAC) model was established on eight-week-old wild-type (WT) and β-arrestin2 deficiency mice to simulate the progression of TMJOA. Hematoxylin-eosin (HE) staining and microcomputed tomography (micro-CT) analysis were used for histological and radiographic assessment. Immunohistochemistry was performed to detect the expression of inflammatory and degradative cytokines, as well as autophagy related factors. Terminal-deoxynucleotidyl transferase mediated nick end labeling (TUNEL) assay was carried out to assess chondrocyte apoptosis. Results The loss of β-arrestin2 aggravated cartilage degeneration and subchondral bone destruction in the model of TMJOA at the early stage. Furthermore, in UAC groups, the expressions of degradative (Col-X) and inflammatory (TNF-α and IL-1β) factors in condylar cartilage were increased in β-arrestin2 null mice compared with WT mice. Moreover, the loss of β-arrestin2 promoted apoptosis and autophagic process of chondrocytes at the early stage of TMJOA. Conclusion In conclusion, we demonstrated for the first time that β-arrestin2 plays a protective role in the development of TMJOA at the early stage, probably by inhibiting apoptosis and autophagic process of chondrocytes. Therefore, β-arrestin2 might be a potential therapeutic target for TMJOA, providing a new insight for the treatment of TMJOA at the early stage.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Loss of β-arrestin2 aggravated condylar cartilage degeneration at the early stage of temporomandibular joint osteoarthritis

Zhu,

Huang,

Qin

et al. 2024

BMC Musculoskelet Disord

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“…В патогенезі остеоартрозу СНЩС прослідковується наявність «порочного кола», що проявляється в перебудові м'язових реакцій у відповідь на деформацію зубних рядів, яке в свою чергу посилює неадекватне навантаження на СНЩС. Це навантаження стимулює запально-дегенеративні процеси в суглобі, і тим самим спричиняє ще більший м'язовий спазм [3]. Оскільки деформація зубних рядів має панівне місце у виникненні всіх порушень СНЩС, етіологічним методом лікування є нормалізація оклюзійних співвідношень за допомогою перебудови міостатичних рефлексів, спрямоване на розслаблення м'язів та зменшення навантаження на СНЩС.…”

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Comparison of the effectiveness of treatment of temporomandibular joint osteoarthritis between monotherapy with splints and splints in combination with platelet-rich plasma

Shynchukovskyi,

Tereshchuk

2024

MTT

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Today there is a tendency to increase the prevalence of Temporomandibular Joint Osteoarthritis (TMJ) osteoarthritis, which is a chronic degenerative joint disease. According to international statistics, 28–38% of people in the age group of 9–90 years have signs of TMJ osteoarthritis. The aim of our study was to compare the effectiveness of treatment of TMJ osteoarthritis between monotherapy with splints and splinys in combination with Platelet-Rich Plasma (PRP). The experiment involved 8 patients, divided into 2 level groups. The control group (4 patients) received treatment with splints, the experimental group – splits with PRP therapy. The effectiveness of treatment was assessed by measuring the radiological density of the cortical plate of the mandibular head according to the Hounsfield scale, the degree of mouth opening, filling out a Visual Analogue Scale (VAS) and a questionnaire at the end of treatment. According to the results of the study, the experimental group received more effective treatment, which is confirmed by the VAS, the degree of mouth opening and changes in the radiological density of the cortical plate of the articular head. At the end of the treatment, patients completed a questionnaire about the improvement of their condition, where 0 points meant no effect from the treatment, and 10 points meant a subjective feeling of complete recovery. The arithmetic mean of the improvement scores in the control group was 6.75, and in the experimental group – 9.00 points. Based on the results of the experiment, we can state that the effectiveness of treatment of TMJ osteoarthritis with splints in combination with PRP therapy is greater than that of monotherapy with occlusal splints. Therefore, if the patient has no contraindications to treatment with platelet-rich plasma, we can recommend the use of splits in combination with PRP therapy for the treatment of temporomandibular joint osteoarthritis. Keywords: degenerative diseases, radiological density, articular head.

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An “All‐in‐One” Strategy to Reconstruct Temporomandibular Joint Osteoarthritic Microenvironment Using γ‐Fe₂O₃@TA@ALN Nanoparticles

Cen,

Deng,

Pan

et al. 2024

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Current clinical strategies for the treatment of temporomandibular joint osteoarthritis (TMJOA) primarily target cartilage biology, overlooking the synergetic effect of various cells and inorganic components in shaping the arthritic microenvironment, thereby impeding the effectiveness of existing therapeutic options for TMJOA. Here, γ‐Fe2O3@TA@ALN magnetic nanoparticles (γ‐Fe2O3@TA@ALN MNPs) composed of γ‐Fe2O3, tannic acid (TA), and alendronate sodium (ALN) are engineered to reconstruct the osteoarthritic microenvironment and mitigate TMJOA progression. γ‐Fe2O3@TA@ALN MNPs can promote chondrocytes’ proliferation, facilitate chondrogenesis and anisotropic organization, enhance lubrication and reduce cartilage wear, and encourage cell movement. Magnetic‐responsive γ‐Fe2O3@TA@ALN MNPs also exhibit pH sensitivity, which undergoes decomposition within acidic environment to release ALN on demand. Under a 0.2 T static magnetic field, γ‐Fe2O3@TA@ALN MNPs accelerate the synthesis of cartilage‐specific proteins, and suppress catabolic‐related genes expression and reactive oxygen species generation, affording additional protection to TMJ cartilage. In TMJOA mouse models, articular injection of γ‐Fe2O3@TA@ALN MNPs effectively alleviates cartilage degeneration and subchondral bone loss in short and long terms, offering promising avenues for the development of therapeutic interventions for TMJOA.

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Potential pathological and molecular mechanisms of temporomandibular joint osteoarthritis

Cited by 10 publications

References 110 publications

Loss of β-arrestin2 aggravated condylar cartilage degeneration at the early stage of temporomandibular joint osteoarthritis

Loss of β-arrestin2 aggravated condylar cartilage degeneration at the early stage of temporomandibular joint osteoarthritis

Comparison of the effectiveness of treatment of temporomandibular joint osteoarthritis between monotherapy with splints and splints in combination with platelet-rich plasma

An “All‐in‐One” Strategy to Reconstruct Temporomandibular Joint Osteoarthritic Microenvironment Using γ‐Fe₂O₃@TA@ALN Nanoparticles

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Potential pathological and molecular mechanisms of temporomandibular joint osteoarthritis

Cited by 10 publications

References 110 publications

Loss of β-arrestin2 aggravated condylar cartilage degeneration at the early stage of temporomandibular joint osteoarthritis

Loss of β-arrestin2 aggravated condylar cartilage degeneration at the early stage of temporomandibular joint osteoarthritis

Comparison of the effectiveness of treatment of temporomandibular joint osteoarthritis between monotherapy with splints and splints in combination with platelet-rich plasma

An “All‐in‐One” Strategy to Reconstruct Temporomandibular Joint Osteoarthritic Microenvironment Using γ‐Fe2O3@TA@ALN Nanoparticles

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An “All‐in‐One” Strategy to Reconstruct Temporomandibular Joint Osteoarthritic Microenvironment Using γ‐Fe₂O₃@TA@ALN Nanoparticles