Potential pharmaceutic effect of Shilajit (mumie) on experimental osteoarthritis in rat

Azizi, Shahrzad; Kheirandiah, Reza; Azari, Omid; Torabi, Nafise

doi:10.1007/s00580-018-2662-0

Cited by 8 publications

(7 citation statements)

References 37 publications

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“…Anti-inflammatory effects: Mumio has been found to have anti-inflammatory effects, which may benefit a range of inflammatory conditions. For example, one study published in the journal Phytotherapy Research found that mumio reduced inflammation and improved joint function in patients with osteoarthritis (Acharya et al 1988;Azizi, et al, 2018).…”

Section: Uses Of Mumio In Traditional Medicinementioning

confidence: 99%

Chemical Characteristics and Biotechnological Potentials of Mumio

ABYLAEVA,

KAYA

2023

Manas Journal of Agriculture Veterinary and Life Sciences

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Mumio is a valuable substance that ranges in color from pale brown to blackish-brown and is obtained from rock layers in various mountain ranges worldwide, particularly in the Tien Shan ranges of Kyrgyzstan. It is also a natural chemical found largely in the Himalayas, created over ages by the progressive degradation of particular plants by bacteria. Mumio is essentially a nutraceutical product with considerable human health advantages. To fully appreciate the predicted impact of mumio use in the medical area, particularly in neurological sciences, more research at both the fundamental biology level and through well-designed clinical trials is required. This involves a thorough examination of the various organic and inorganic elements that contribute to Mumio's therapeutic efficacy.The paper also dives into the results of Mumio's comprehensive biological and biotechnological analyses. These scientific research have revealed the mechanisms of action of this natural chemical and confirmed its medicinal claims. The article seeks to offer a full review of Mumio by merging traditional medicine knowledge, chemical analysis, and scientific assessments, stressing its relevance in traditional medicine and its potential for life science activities.

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Section: Uses Of Mumio In Traditional Medicinementioning

confidence: 99%

Chemical Characteristics and Biotechnological Potentials of Mumio

ABYLAEVA,

KAYA

2023

Manas Journal of Agriculture Veterinary and Life Sciences

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“…In addition to Shilajit benefits for diabetes (Gupta et al, 2016;Raju & Sharma, 2016), it can also be beneficial for other diseases and conditions, including insulin resistance (Gupta, 1966;Kanikkannan et al, 1995), obesity Pattonder et al, 2011), inflammation (Firozsalari et al;Pingali & Nutalapati, 2022), oxidative stress (Atashbar et al, 2018;Derhami et al, 2022), arthritis (Azizi et al, 2018;Lawley et al, 2013), cancer (Kloskowski et al, 2021;Pant et al, 2012), bone health (Cesur et al, 2019;Labban, 2013), allergy (Ghosal et al, 1989;Sadeghi et al, 2020), mental health (Jaiswal & Bhattacharya, 1992;Khaksari et al, 2013), immune system (Bižanov et al, 2012;Musthafa et al, 2018), increased energy (Bhattacharyya et al, 2009;Stohs et al, 2017), adaptogenic (Agarwal et al, 2007;Bansal & Banerjee, 2016), antiaging and rejuvenating (Ghosal, 1990;Wilson et al, 2011), and for sexual health (Ikram-ul-Haq et al, 2016;NİZAM & SELÇUK, 2021). These benefits are shown in table 2.…”

Section: Shilajit Studies On Other Diseases and Conditionsmentioning

confidence: 99%

“…Research Reference/(s) Diseases/conditions (Gupta et al, 2016;Raju & Sharma, 2016) Diabetes (Ghezelbash et al, 2022;Kanikkannan et al, 1995) Insulin resistance (Patil et al, 2022;Pattonder et al, 2011) Obesity (Firozsalari et al;Pingali & Nutalapati, 2022) Inflammation (Atashbar et al, 2018;Derhami et al, 2022) Oxidative stress (Azizi et al, 2018;Lawley et al, 2013) Arthritis (Kloskowski et al, 2021;Pant et al, 2012) Cancer (Cesur et al, 2019;Labban, 2013) Bone health (Ghosal et al, 1989) Allergy (Jaiswal & Bhattacharya, 1992) Mental health (Bižanov et al, 2012;Musthafa et al, 2018) Immune system (Bhattacharyya et al, 2009;Stohs et al, 2017) Increase Energy (Agarwal et al, 2007;Bansal & Banerjee, 2016) Adaptogenic (adapt to stress) (Ghosal, 1990;Wilson et al, 2011) Anti-aging and rejuvenator (Ikram-ul-Haq et al, 2016;NİZAM & SELÇUK, 2021) Sexual health * Please note that studies include animals and humans…”

Section: Shilajit Studies On Other Diseases and Conditionsmentioning

confidence: 99%

Untitled

2023

JJBS

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Study areas include cell biology, genomics, microbiology, immunology, molecular biology, biochemistry, embryology, immunogenetics, cell and tissue culture, molecular ecology, genetic engineering and biological engineering, bioremediation and biodegradation, bioinformatics, biotechnology regulations, gene therapy, organismal biology, microbial and environmental biotechnology, marine sciences. The JJBS welcomes the submission of manuscript that meets the general criteria of significance and academic excellence. All articles published in JJBS are peerreviewed. Papers will be published approximately one to two months after acceptance.

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“…Besides, fulvic acid facilitates importing minerals into the target cells, protecting the electrical potential and preventing cell death [21,22]. The safety and healing efficacy of Shilajit has been studied in humans and animals [18].The Shilajit compounds exhibit a great potential for healing the different diseases such as bone fractures, osteoarthritis [23,24], anemia [25], diabetes [26] and Alzheimer [27]. A clinical trial conducted in Iran revealed that oral administration of Shilajit after tibia fracture surgery accelerated bone repair [28].…”

Section: Open Accessmentioning

confidence: 99%

Accelerating effect of Shilajit on osteogenic property of adipose-derived mesenchymal stem cells (ASCs)

et al. 2022

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Background Shilajit has been widely used remedy for treating a numerous of illness such as bone defects in Iran traditional folk medicine since hundreds of years ago. The aim of the present study was to explore the effect of Shilajit on the osteogenic differentiation of human adipose-derived mesenchymal stem cells (ASCs) in two- (2D) and three-dimensional (3D) cultures. Materials and methods ASCs were seeded in 3D 1% alginate (Alg) hydrogel with or without Shilajit (500 µg/mL) and compared with 2D cultures. Then, characterization was done using electron microscopy (SEM)/energy-dispersive X-ray spectroscopy (EDX), alkaline phosphatase (ALP) activity, alizarin red staining and Raman confocal microscopy. Results Adding Shilajit had no impact on the Alg scaffold degradability. In the 3D hydrogel and in the presence of osteogenic medium (OM), Shilajit acted as enhancer to increase ALP activity and also showed osteoinductive property in the absence of OM compared to the 2D matched groups at all time points (days 7 and 21 both P = 0.0006, for 14 days P = 0.0006 and P = 0.002, respectively). In addition, calcium deposition was significantly increased in the cultures exposed to Shilajit compared to 2D matched groups on days 14 (P < 0.0001) and 21 (P = 0.0003 and P = 0.003, respectively). In both 3D and 2D conditions, Shilajit induced osteogenic differentiation, but Shilajit/Alg combination starts osteogenic differentiation in a short period of time. Conclusion As Shilajit accelerates the differentiation of ASCs into the osteoblasts, without changing the physical properties of the Alg hydrogel, this combination may pave the way for more promising remedies considering bone defects.

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Potential pharmaceutic effect of Shilajit (mumie) on experimental osteoarthritis in rat

Cited by 8 publications

References 37 publications

Chemical Characteristics and Biotechnological Potentials of Mumio

Chemical Characteristics and Biotechnological Potentials of Mumio

Untitled

Accelerating effect of Shilajit on osteogenic property of adipose-derived mesenchymal stem cells (ASCs)

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