Potential protection of indocyanine green on parathyroid gland function during near-infrared laparoscopic-assisted thyroidectomy: A case report and literature review

Peng, Shujia; Yang, Ping; Dong, Yanming; Yang, Lin; Yang, Zhenyu; Hu, Xie; Bao, Guoqiang

doi:10.12998/wjcc.v8.i21.5480

Cited by 3 publications

(3 citation statements)

References 34 publications

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“…Furthermore, the signi cantly lower rate of postoperative lymph node recurrence in the experimental group suggests that the use of nano-carbon suspension may improve oncological outcomes in PTC surgeries. This aligns with previous studies indicating that enhanced visibility of surgical landmarks can lead to more thorough dissections without compromising oncological e cacy [24][25][26] .…”

Section: Impact On Complications and Recurrencesupporting

confidence: 91%

Enhancing parathyroid preservation in papillary thyroid carcinoma surgery using nano-carbon suspension

Lin,

Zhuo,

Lin

et al. 2024

Preprint

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This study evaluates the clinical significance of using nano-carbon suspension in total thyroidectomy with cervical lymph node dissection for papillary thyroid carcinoma (PTC). The objective is to assess the efficacy of nano-carbon in enhancing parathyroid gland preservation, reducing postoperative complications, and improving surgical precision. A retrospective analysis of 219 PTC patients who underwent total thyroidectomy and cervical lymph node dissection from March 2014 to March 2018 was conducted. Patients were divided into two groups: control (n = 112) without nano-carbon suspension and experimental (n = 107) with nano-carbon suspension. Comparative analyses included demographics, surgical parameters, postoperative calcium and parathyroid hormone (PTH) levels, number of lymph nodes dissected, and incidence of complications. Baseline characteristics, including age, sex, and BMI, were comparable between the experimental and control groups, with no statistically significant differences observed. Postoperative calcium levels were significantly more stable in the experimental group, with median levels of 2.22 mmol/L on day 1 compared to 2.06 mmol/L in the control group (p < 0.001), and 2.29 mmol/L at week 1 compared to 2.22 mmol/L in the control group (p < 0.001). PTH levels were also higher in the experimental group (35 pg/mL on day 1 vs. 28 pg/mL, p < 0.001; 37 pg/mL at week 1 vs. 30 pg/mL, p < 0.001). The experimental group had more lymph nodes dissected (median 135.83 vs. 84.12, p < 0.001) and a lower pathological parathyroid gland count (6.5% vs. 23.2%, p < 0.001). Postoperative numbness and twitching were reduced (4.7% vs. 16.1%, p = 0.006), and the recurrence rate at 12 months was lower (4.7% vs. 12.5%, p = 0.040). Nano-carbon suspension in thyroidectomy with cervical lymph node dissection for PTC enhances parathyroid gland preservation, improves surgical precision, and reduces specific postoperative complications, advocating its standard use in thyroid cancer surgeries to optimize patient outcomes.

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Section: Impact On Complications and Recurrencesupporting

confidence: 91%

Enhancing parathyroid preservation in papillary thyroid carcinoma surgery using nano-carbon suspension

Lin,

Zhuo,

Lin

et al. 2024

Preprint

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“…Due to the depth of NIR, radiation only reaches a depth of approximately 10 mm ( 75 ). Surgeons need to illuminate the operative field with a NIRAF projector when the thyroid gland is retracted ( 106 , 127 ). The adipose tissue around the PG may influence the effect and cause a negative result ( 27 ).…”

Section: Icg-nir Fluorescence Imagingmentioning

confidence: 99%

“…The application of the NIRAF imaging system can realize the role of position. The intravenous administration of ICG is as follows: in endoscopic surgery, some scholars choose to inject ICG 1 h before anesthesia ( 127 ). Currently, most surgeons prefer to administer the drug intravenously after thyroid exposure, despite the technique used ( 128 , 129 ).…”

Section: Icg-nir Fluorescence Imagingmentioning

confidence: 99%

The magic mirror: a novel intraoperative monitoring method for parathyroid glands

et al. 2023

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The accurate detection of parathyroid glands (PGs) during surgery is of great significance in thyroidectomy and parathyroidectomy, which protects the function of normal PGs to prevent postoperative hypoparathyroidism and the thorough removal of parathyroid lesions. Existing conventional imaging techniques have certain limitations in the real-time exploration of PGs. In recent years, a new, real-time, and non-invasive imaging system known as the near-infrared autofluorescence (NIRAF) imaging system has been developed to detect PGs. Several studies have confirmed that this system has a high parathyroid recognition rate and can reduce the occurrence of transient hypoparathyroidism after surgery. The NIRAF imaging system, like a magic mirror, can monitor the PGs during surgery in real time, thus providing great support for surgeries. In addition, the NIRAF imaging system can evaluate the blood supply of PGs by utilizing indocyanine green (ICG) to guide surgical strategies. The NIRAF imaging system and ICG complement each other to protect normal parathyroid function and reduce postoperative complications. This article reviews the effectiveness of the NIRAF imaging system in thyroidectomies and parathyroidectomies and briefly discusses some existing problems and prospects for the future.

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Enhancing parathyroid preservation in papillary thyroid carcinoma surgery using nano-carbon suspension

Lin,

Zhuo,

Lin

et al. 2024

Sci Rep

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This study evaluates the clinical significance of nano-carbon suspension in total thyroidectomy with cervical lymph node dissection for papillary thyroid carcinoma (PTC). The objective of this study was to assess the efficacy of nano-carbon suspension in enhancing parathyroid gland preservation, reducing postoperative complications, and improving surgical precision. A retrospective analysis on 219 PTC patients who underwent total thyroidectomy with cervical lymph node dissection between March 2014 and March 2018 was conducted. Patients were divided into two groups: an experimental group ( n = 107) that received nano-carbon suspension and a control group ( n = 112) that did not. Comparative analyses included demographics, surgical parameters, postoperative calcium and parathyroid hormone (PTH) levels, the number of dissected lymph nodes, and the incidence of complications. Baseline characteristics, including age, sex, and BMI, showed no statistically significant differences between the experimental and control groups. Postoperative calcium levels were significantly more stable in the experimental group, with median levels of 2.22 mmol/L on day 1 versus 2.06 mmol/L in the control group ( P < 0.001), and 2.29 mmol/L at week 1 versus 2.22 mmol/L ( P < 0.001). PTH levels were higher in the experimental group (35 pg/mL on day 1 versus 28 pg/mL, P < 0.001; 37 pg/mL at week 1 versus 30 pg/mL, P < 0.001). The experimental group had a greater median number of dissected lymph nodes (median 11.00 versus 7.00, P < 0.001) and a lower pathological parathyroid gland count (6.5% versus 23.2%, P < 0.001). Postoperative numbness and twitching were significantly reduced (4.7% versus 16.1%, P = 0.006), and the recurrence rate at 12 months was lower (4.7% versus 12.5%, P = 0.040). The use of Nano-carbon suspension in thyroidectomy and cervical lymph node dissection for PTC enhances parathyroid gland preservation, improves surgical precision, and reduces specific postoperative complications, supporting its standard adoption in thyroid cancer surgeries to optimize patient outcomes.

show abstract

Potential protection of indocyanine green on parathyroid gland function during near-infrared laparoscopic-assisted thyroidectomy: A case report and literature review

Cited by 3 publications

References 34 publications

Enhancing parathyroid preservation in papillary thyroid carcinoma surgery using nano-carbon suspension

Enhancing parathyroid preservation in papillary thyroid carcinoma surgery using nano-carbon suspension

The magic mirror: a novel intraoperative monitoring method for parathyroid glands

Enhancing parathyroid preservation in papillary thyroid carcinoma surgery using nano-carbon suspension

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