Potential protective effect of curcumin in high-fat diet-induced nonalcoholic fatty liver disease in rats

Mahmouda, Ahmed M M.; El-Hagag, Noha A.-R A.; El-Bitar, Hussein; Afifi, Abdel-Halim M.

doi:10.4103/jcmrp.jcmrp_37_20

Cited by 8 publications

(5 citation statements)

References 42 publications

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“…Together with the laboratory findings, these abnormalities proved the successful induction of NAFLD which is in agreement with former reports in animal models [18], [19]. The histological examination of liver structure in rat-induced NAFL was also accompanied by changes in lipid profile and liver enzyme.…”

Section: : Photomicrographs Of Immunostained Liver Sections For Caspa...supporting

confidence: 90%

Potential Protective Effect of Zingiber officinale in Comparison to Rosuvastatin on High-fat diet-induced Non-alcoholic Fatty Liver Disease in Rats

Ramadan

Nasr

El-Hay

et al. 2022

Open Access Maced J Med Sci

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BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is a common liver disease affecting nearly 25% of adults worldwide with related risk factors including obesity, metabolic, and inflammatory diseases. Many therapeutic remedies of natural or synthetic properties were used. AIM: This study aimed to investigate and compare the effects of ginger/rosuvastatin (ROSU) on the liver of rats with induced NAFLD. MATERIALS AND METHODS: Forty adult male albino rats were used in this study and divided into four equal subgroups, Group I, control received the standard rat chow diet and given normal saline (1 ml/kg/day), Group II, high-fat diet (HFD) group, Group III, received HFD+ ROSU (15 mg/kg/day), and Group IV, HFD+ Zingiber officinale (10% W/V) for 6 weeks. At the end of our experiment, the rats were sacrificed then blood samples were collected for biochemical analysis of lipid profiles and liver enzymes, liver specimen was prepared for light and electron microscopic examination, and measurement of tissue level of malondialdehyde. RESULTS: NAFLD caused degenerative changes and lipid deposition in liver cells as evidenced by microscopic results and laboratory tests. Treatment with ginger/ROSU alleviated those changes. CONCLUSION: Ginger and ROSU could ameliorate liver functions in NAFLD and ginger effect is superior to ROSU.

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Section: : Photomicrographs Of Immunostained Liver Sections For Caspa...supporting

confidence: 90%

Potential Protective Effect of Zingiber officinale in Comparison to Rosuvastatin on High-fat diet-induced Non-alcoholic Fatty Liver Disease in Rats

Ramadan

Nasr

El-Hay

et al. 2022

Open Access Maced J Med Sci

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“…In the present study, the histopathological observations were done in the liver, duodenum, and heart of the HFD group. These findings were in parallel with van der Heijden et al [ 70 ], Mahmoud et al [ 74 ], and Avtanski et al [ 81 ], who confirmed that the rats fed on a high-fat diet showed marked steatosis in a diffused manner all over the hepatocytes associated with focal necrosis and hepatocellular ballooning.…”

Section: Discussionsupporting

confidence: 85%

“…Curcumin may exert its anti-inflammatory effects through several signaling pathways that are associated with inflammation including the TLR-4 pathway via TLR-4 acting directly on receptor stimulation, by its downstream pathway, or by regulating target proteins in the inflammatory signaling TLR-4 pathway [ 73 , 74 ].…”

Section: Discussionmentioning

confidence: 99%

Antitoxic Effects of Curcumin against Obesity-Induced Multi-Organs’ Biochemical and Histopathological Abnormalities in an Animal Model

Hassan

Awadalla

El-Kader

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Background. Obesity is a significant public health problem that is characterized by an increase in oxidative stress and enhanced inflammatory responses associated with immune cell invasion of adipose tissues. This study assessed several biochemical abnormalities, apoptosis, oxidative stress status, and associated histological changes in the liver, duodenum, and heart brought on by high-fat diet-induced obesity in rats. It also assessed the mechanistic benefits of curcumin in reversing these inflammatory, metabolic, and histological impairments. Methods. Rats were assigned into three groups each including ten rats: the control group (CD), the high-fat diet group (HFD), and the high-fat diet + curcumin (HFDC) group. Serum glucose, insulin, and triglycerides (TAGs) were observed. In addition, apoptosis (indicated by hepatic DNA fragmentation) and oxidative stress status (indicated by hepatic MPO, GSH, and SOD) were assessed. Histopathological examinations included the GIT (liver and duodenum) and heart in addition to quantitative real-time polymerase chain reaction (qRT-PCR) assays of the adipose tissue genetic expressions for inflammatory signaling pathways (TLR4, IL-6, and TNF-α). Results. The overall findings showed that the HFD group exhibited significantly higher levels of glucose, TAGs, and insulin than the control group ( P < 0.01 ). The histological abnormalities of the studied organs in the HFD group were paralleled by these biochemical abnormalities, which were strongly associated with increased apoptosis, increased oxidative stress, and increased expression of the inflammatory signaling markers. There were significant improvements in the HFDC group in terms of biochemical, inflammatory, and histological investigations. Conclusions. This study’s findings concluded that obesity is significantly associated with biochemical and microscopic alterations in many organs. Curcumin exerted potent antitoxic, antioxidant, tissue-protective, and antiobesity effects. Curcumin is recommended to be added to various dietary regimens to prevent or delay the organs’ dysfunction among obese people.

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“…Oxidative stress, through the generation of ROS, induces lipid peroxidation, destroying unsaturated FFAs in the cell membranes, causing a decrease in endogenous antioxidants, thus resulting in liver tissue damage. Recently, Mahmouda A. et al showed that curcumin decreased MDA levels and restored glutathione peroxidase (GPx) activity in the liver tissue of MASH mice [47]. There is a close relationship between the dysregulation of lipid homeostasis and oxidative stress, as ROS production induced by fat and by proinflammatory cytokines storm contributes to the onset and progression of MASLD [66].…”

Section: Curcumin Modulates Lipid Metabolismmentioning

confidence: 99%

Molecular Mechanisms of Curcumin in the Pathogenesis of Metabolic Dysfunction Associated Steatotic Liver Disease

Guariglia,

Saba,

Rosso

et al. 2023

Nutrients

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Metabolic dysfunction-associated steatotic liver disease (MASLD) is a multifactorial condition characterized by insulin resistance, oxidative stress, chronic low-grade inflammation, and sometimes fibrosis. To date, no effective pharmacological therapy has been approved for the treatment of metabolic-associated steatohepatitis (MASH), the progressive form of MASLD. Recently, numerous in vitro and in vivo studies have described the efficacy of nutraceutical compounds in the diet has been tested. Among them, curcumin is the most widely used polyphenol in the diet showing potent anti-inflammatory and antifibrotic activities. This review aims to summarize the most important basic studies (in vitro and animal models studies), describing the molecular mechanisms by which curcumin acts in the context of MASLD, providing the rationale for its effective translational use in humans.

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Potential protective effect of curcumin in high-fat diet-induced nonalcoholic fatty liver disease in rats

Cited by 8 publications

References 42 publications

Potential Protective Effect of Zingiber officinale in Comparison to Rosuvastatin on High-fat diet-induced Non-alcoholic Fatty Liver Disease in Rats

Potential Protective Effect of Zingiber officinale in Comparison to Rosuvastatin on High-fat diet-induced Non-alcoholic Fatty Liver Disease in Rats

Antitoxic Effects of Curcumin against Obesity-Induced Multi-Organs’ Biochemical and Histopathological Abnormalities in an Animal Model

Molecular Mechanisms of Curcumin in the Pathogenesis of Metabolic Dysfunction Associated Steatotic Liver Disease

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