Potential Protective Effects of Nigella Sativa and Allium Sativum Against Fructose-Induced Metabolic Syndrome in Rats

Nigella sativa (black seed) effects on plasma lipid concentrations in humans: A systematic review and meta-analysis of randomized placebo-controlled trials

“…Almost all previous experimental studies in animals [23,24,26,[31][32][33][34][35][36][37][38][39][40][41][42][43][44][79][80][81], but one [25], showed a reduction in LDL-C after NS supplementation. Consistently, small clinical studies confirmed a significant LDL-C reduction after the consumption of NS in both healthy individuals [27] and dysmetabolic patients [28,29,45].…”

“…The divergent results may be due to differences in dosage and type of NS supplementation, dietary habits, physical activity level, duration of the intervention, ethnicity, laboratory and clinical characteristics of the patients studied. Indeed, an HDL-C increase was reported in studies where participants were assigned to an exercise program [51,60], in experimental studies where NS determined a relevant decrement of triglycerides and insulin resistance, thus resulting in a lower clearance of HDL [25,36,54], or in studies administering seed powder [52]. A possible explanation for the superiority of seed powder on HDL-C may be the higher content of seeds of unsaturated fatty acids, mainly linoleic and oleic acids [16].…”

“…Therefore, the lipid-lowering action of NS has been evaluated both in different experimental models, varying from normal [22] to dyslipidemic [23,24], dysmetabolic [25], and diabetic animals [26], and in clinical studies, performed in healthy [27], dyslipidemic [28], dysmetabolic [29], and diabetic subjects [30]. Supplementation with NS has been associated with decreased concentrations of serum total cholesterol [23,24,[26][27][28][29][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45], triglycerides [2, 23, 24, 26, 28, 31, 32, 34-41, 43, 44, 46], and/or increased concentrations of highdensity lipoprotein cholesterol (HDL-C) [23, 25, 28, 32, 34-36, 39, 41-44].…”

Preclinical and clinical effects of Nigella sativa and its constituent, thymoquinone: A review

“…The N. sativa seed ethanol extract could also inhibit gluconeogenesis by the liver and muscle activation of adenosine monophosphate-activated protein kinase (AMPK)(Benhaddou-Andaloussi et al, 2011). It was demonstrated that TQ (the main constituent of N. sativa) could reduce the expression of gluconeogenic enzymes (glucose-6-phosphatase and fructose 1, 6 bisphosphatase) and hepatic glucose production(Al-Rasheed et al, 2014;Alimohammadi et al, 2013). TQ could increase the uptake of low-density lipoprotein-cholesterol (LDL-C) by upregulation of hepatic receptors of LDL-C(Ibrahim et al, 2014a).…”

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“…Several possible mechanisms have been proposed for justifying these effects. It was demonstrated that TQ might reduce the expression of gluconeogenic enzymes viz., glucose-6-phosphatase, fructose 1, 6 bi-phosphatase and hepatic glucose production 28,29 . TQ could enhance the uptake of low-density lipoprotein-cholesterol (LDL-C) by upregulation of LDL-C hepatic receptors 30 .…”