Potential protective effects of quercetin and curcumin on paracetamol-induced histological changes, oxidative stress, impaired liver and kidney functions and haematotoxicity in rat

Yousef, Mokhtar I.; Omar, Sahar A.M.; El-Guendi, Marwa I.; Abd-Elmegid, Laila A.

doi:10.1016/j.fct.2010.08.034

Cited by 247 publications

(177 citation statements)

References 51 publications

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“…To date, a number of studies have suggested the involvement of oxidative stress as the mediator of PCM-induced nephrotoxicity (Das et al, 2010;Kheradpezhouh et al, 2010;Yousef et al, 2010). Hart et al (1994) pointed out that PCM toxicity was shown to enhance NAPQI production.…”

Section: Discussionmentioning

confidence: 99%

Nephroprotective effects of Zingiber zerumbet Smith ethyl acetate extract against paracetamol-induced nephrotoxicity and oxidative stress in rats

Hamid

Budin

et al. 2012

J. Zhejiang Univ. Sci. B

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Abstract:Paracetamol (PCM) overdose can cause nephrotoxicity with oxidative stress as one of the possible mechanisms mediating the event. In this study, the effects of ethyl acetate extract of Zingiber zerumbet rhizome [200 mg per kg of body weight (mg/kg) and 400 mg/kg] on PCM-induced nephrotoxicity were examined. Rats were divided into five groups containing 10 rats each. The control group received distilled water while other groups were treated with extract alone (400 mg/kg), PCM alone (750 mg/kg), 750 mg/kg PCM+200 mg/kg extract (PCM+ 200-extract), and 750 mg/kg PCM+400 mg/kg extract (PCM+400-extract), respectively, for seven consecutive days. The Z. zerumbet extract was given intraperitoneally concurrent with oral administration of PCM. Treatment with Z. zerumbet extract at doses of 200 and 400 mg/kg prevented the PCM-induced nephrotoxicity and oxidative impairments of the kidney, as evidenced by a significantly reduced (P<0.05) level of plasma creatinine, plasma and renal malondialdehyde (MDA), plasma protein carbonyl, and renal advanced oxidation protein product (AOPP). Furthermore, both doses were also able to induce a significant increment (P<0.05) of plasma and renal levels of glutathione (GSH) and plasma superoxide dismutase (SOD) activity. The nephroprotective effects of Z. zerumbet extract were confirmed by a reduced intensity of renal cellular damage, as evidenced by histological findings. Moreover, Z. zerumbet extract administered at 400 mg/kg was found to show greater protective effects than that at 200 mg/kg. In conclusion, ethyl acetate extract of Z. zerumbet rhizome has a protective role against PCM-induced nephrotoxicity and the process is probably mediated through its antioxidant properties.

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Section: Discussionmentioning

confidence: 99%

Nephroprotective effects of Zingiber zerumbet Smith ethyl acetate extract against paracetamol-induced nephrotoxicity and oxidative stress in rats

Hamid

Budin

et al. 2012

J. Zhejiang Univ. Sci. B

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“…March, trunk wood resin, against acetaminopheninduced liver injury in mice through modulating the oxidative stress/antioxidant parameters (Oliveira et al 2005). The protective effects of quercetin and curcumin on paracetamol-induced liver injury in the rat through modulating the oxidative stress/ antioxidant parameters has also been reported (Yousef et al 2010). The protective effect of Aquilegia vulgaris (L.) on APAP-induced oxidative stress in rats was mediated by amelioration of microsomal lipid peroxidation and restoring the antioxidant enzymes activity (Jodynis-Liebert et al 2005).…”

Section: Discussionmentioning

confidence: 92%

Hepatoprotective effects of Iranian Hypericum scabrum essential oils against oxidative stress induced by acetaminophen in rats

Dadkhah

Fatemi

Farsani

et al. 2014

Braz. arch. biol. technol.

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“…As shown in Table 2 sulfadiazine at dose 10 mg, 30 mg and 70 mg decreased GSH levels in the cells in a concentration dependent manner. Therefore, it can be assumed that the reduction in GSH concentration might cause the effectiveness of GST and GPx activity to be restricted, as evident by the intensification of lipid peroxidation [17]. We suspected that the observed increased concentration of lipid peroxides, along with decreased GSH was capable of inducing some injuries such as apoptosis visible at the cellular level.…”

Section: Discussionmentioning

confidence: 99%

Histopathological Evaluation of Dose Dependent Sulfadiazine-Associated Nephrotoxicity and Alteration on Oxidative Stress in Chicken Embryos

Sayrafi

Golshahi

Araghi

et al. 2016

Zahedan J Res Med Sci

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Background: Numerous epidemiological and experimental researches indicate that in utero exposure to some environmental chemicals and prescribed drugs during pregnancy can mediate various embryonic abnormalities and complications via reactive oxygen species (ROS) generation, which damages cellular macromolecules. Objectives: The aim of the present study was to evaluate the sulfonamide-associated nephrotoxicity with possible underlying mechanisms in chicken embryo. Materials and Methods:In this experimental study, one hundred fertile eggs were obtained and divided into five groups: 1) control group (without injection), 2) group injected with 2 mg sulfadiazine, 3) group injected with 10 mg sulfadiazine, 4) group injected with 30 mg sulfadiazine and 5) group injected with 70 mg sulfadiazine. After hatching, the renal tissue from the newly hatched chick was harvested for histopathologic investigation and also measurement of oxidative stress parameters [the ferric reducing capacity assay, the glutathione content (GSH) and the situation of lipid peroxidation (LPO)] by spectrophotometer. Results: Histologic examination of the renal tissue revealed that sulfadiazine induces hydropic degeneration, tubular necrosis, glomerular and tubular atrophy, formation of hyaline cast, congestion, hemorrhage, interstitial nephritis and fibrosis. Conclusions: Result showed the dose-dependent administration of sulfadiazine significantly altered the histopathologic structure of renal tissues of chickens. Furthermore, the major histopathologic events in the course of sulfadiazine cytotoxicity are renal tubule epithelial cell necrosis, interstitial nephritis and fibrosis, formation of hyaline cast and congestion and hemorrhage, although sulfadiazine at dose 30 mg and 70 mg caused perturbation in antioxidant defense system by marked increase in LPO, and decrease in GSH.

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Potential protective effects of quercetin and curcumin on paracetamol-induced histological changes, oxidative stress, impaired liver and kidney functions and haematotoxicity in rat

Cited by 247 publications

References 51 publications

Nephroprotective effects of Zingiber zerumbet Smith ethyl acetate extract against paracetamol-induced nephrotoxicity and oxidative stress in rats

Nephroprotective effects of Zingiber zerumbet Smith ethyl acetate extract against paracetamol-induced nephrotoxicity and oxidative stress in rats

Hepatoprotective effects of Iranian Hypericum scabrum essential oils against oxidative stress induced by acetaminophen in rats

Histopathological Evaluation of Dose Dependent Sulfadiazine-Associated Nephrotoxicity and Alteration on Oxidative Stress in Chicken Embryos

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