Potential protective roles of curcumin against cadmium-induced toxicity and oxidative stress

Park, Jae Hyeon; Lee, Byung Mu; Kim, Hyung Sik

doi:10.1080/10937404.2020.1860842

Cited by 69 publications

(21 citation statements)

References 199 publications

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“…Rakshit et al [44] Hou et al [55] Yang et al [66] Sudeep et al [77] Lukitasari et al [88] Santana-Galvez et al [94] Cha et al [95] Wang et al [96] Santana-Galvez et al [94] Zeng et al [21] Chen et al [34] Zatorski et al [35] CUR Nakamae et al [36] Gupta et al [37] Gersey et al [38] Yu et al [39] Hamidie et al [40] Pan et al [41] Abadi et al [42] Park et al [43] Wang et al [45] Pimentel-Gutierrez et al […”

Section: Cgamentioning

confidence: 99%

Anti-Cancer Effects of Dietary Polyphenols via ROS-Mediated Pathway with Their Modulation of MicroRNAs

et al. 2022

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Consumption of coffee, tea, wine, curry, and soybeans has been linked to a lower risk of cancer in epidemiological studies. Several cell-based and animal studies have shown that dietary polyphenols like chlorogenic acid, curcumin, epigallocatechin-3-O-gallate, genistein, quercetin and resveratrol play a major role in these anticancer effects. Several mechanisms have been proposed to explain the anticancer effects of polyphenols. Depending on the cellular microenvironment, these polyphenols can exert double-faced actions as either an antioxidant or a prooxidant, and one of the representative anticancer mechanisms is a reactive oxygen species (ROS)-mediated mechanism. These polyphenols can also influence microRNA (miR) expression. In general, they can modulate the expression/activity of the constituent molecules in ROS-mediated anticancer pathways by increasing the expression of tumor-suppressive miRs and decreasing the expression of oncogenic miRs. Thus, miR modulation may enhance the anticancer effects of polyphenols through the ROS-mediated pathways in an additive or synergistic manner. More precise human clinical studies on the effects of dietary polyphenols on miR expression will provide convincing evidence of the preventive roles of dietary polyphenols in cancer and other diseases.

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Section: Cgamentioning

confidence: 99%

Anti-Cancer Effects of Dietary Polyphenols via ROS-Mediated Pathway with Their Modulation of MicroRNAs

et al. 2022

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“…Curcumin (Cur) or diferuloylmethane (1,7-bis(4-hydroxy-3-methoxyphenyl)-16-heptadiene-3,5-dione) is a hydrophobic polyphenol extracted from the rhizome of Curcuma longa L., commonly known as turmeric. Its protective effect on kidney damage, associated with its antioxidant, anti-inflammatory and anti-tumorigenesis properties, has been broadly described in several experimental models [ 34 , 35 ].…”

Section: Introductionmentioning

confidence: 99%

Cadmium-Induced Kidney Injury in Mice Is Counteracted by a Flavonoid-Rich Extract of Bergamot Juice, Alone or in Association with Curcumin and Resveratrol, via the Enhancement of Different Defense Mechanisms

et al. 2021

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Cadmium (Cd) represents a public health risk due to its non-biodegradability and long biological half-life. The main target of Cd is considered the kidney, where it accumulates. No effective treatment for Cd poisoning is available so that several therapeutic approaches were proposed to prevent damages after Cd exposure. We evaluated the effects of a flavonoid-rich extract of bergamot juice (BJe), alone or in association with curcumin (Cur) and resveratrol (Re), in the kidney of mice exposed to cadmium chloride (CdCl2). Male mice were administered with CdCl2 and treated with Cur, Re, or BJe alone or in combination for 14 days. The kidneys were processed for biochemical, structural and morphometric evaluation. Cd treatment significantly increased urea nitrogen and creatinine levels, along with tp53, Bax, Nos2 and Il1b mRNA, while reduced that of Bcl2, as well as glutathione (GSH) content and glutathione peroxidase (GPx) activity. Moreover, Cd caused damages to glomeruli and tubules, and increased Nrf2, Nqo1 and Hmox1 gene expression. Cur, Re and BJe at 40 mg/kg significantly improved all parameters, while BJe at 20 mg/kg showed a lower protective effect. After treatment with the associations of the three nutraceuticals, all parameters were close to normal, thus suggesting a new potential strategy in the protection of renal functions in subjects exposed to environmental toxicants.

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“…Cadmium is a pervasive environmental pollutant that causes hepatotoxicity, and nephrotoxicity (Ezedom and Asagba 2016; Wang et al 2017), induces carcinogenicity, mutagenicity, and cytotoxicity (Park et al 2020). The cells of proximal convoluted tubules in the kidney are the most targeted site of Cd toxicity (Veljkovic et al 2012).…”

Section: Resultsmentioning

confidence: 99%

Ameliorative effect of Azima tetracantha extract on Cadmium induced Hepato-Renal oxidative stress: An in vivo approach

Rani¹,

Hema²,

Ranganathan³

et al. 2022

Journal of Pharmaceutical Negative Results

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Cadmium (Cd), an environmental pollutant affects humans through contaminated foodstuffs and industrial processes. Cd accumulates in various organs upon exposure and the primary targets are kidney and liver. Its toxicity induces free radicals, creating oxidative stress, defects in antioxidant mechanism, damage to membrane proteins, DNA damage, necrosis, and apoptosis. In this study hepatoprotective and nephroprotective activity of Azima tetracantha towards Cd-induced toxicity was investigated by in vivo approach. Ultra Violet (UV) spectral and Fourier Transform Infra-Red (FTIR) analysis of methanol extract of the Azima tetracantha leaves revealed phenolic compounds. Cadmium Chloride (CdCl2) exposure in Wister Albino rats showed a marked increase in lipid profile, enzymatic antioxidants, and non-enzymatic antioxidants. Co-administration of a methanol extract of Azima tetracantha leaves (500 mg/kg/day) with CdCl2 resulted in the reversal of toxicity effects in the kidney and hepatic cells by maintaining the normal histological architecture. Further, reduced lipid peroxidation and increased antioxidant defense system activity were observed. Hence, the current study suggests that the nephroprotective and hepatoprotective efficacy of Azima tetracantha in Cd-induced toxicity might result from its antioxidant and metal chelating characteristics that might benefit in reaching the best remedy in Cd-induced damage.

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Potential protective roles of curcumin against cadmium-induced toxicity and oxidative stress

Cited by 69 publications

References 199 publications

Anti-Cancer Effects of Dietary Polyphenols via ROS-Mediated Pathway with Their Modulation of MicroRNAs

Anti-Cancer Effects of Dietary Polyphenols via ROS-Mediated Pathway with Their Modulation of MicroRNAs

Cadmium-Induced Kidney Injury in Mice Is Counteracted by a Flavonoid-Rich Extract of Bergamot Juice, Alone or in Association with Curcumin and Resveratrol, via the Enhancement of Different Defense Mechanisms

Ameliorative effect of Azima tetracantha extract on Cadmium induced Hepato-Renal oxidative stress: An in vivo approach

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