Potential radiation dose to a breast-fed infant following administration of sodium 32P-phosphate to the mother

Mountford,; Wells, *; Hall, '; Coakley,

doi:10.1097/00006231-198407000-00007

Cited by 4 publications

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“…Having objective information on medications and their effect on nursing children can enable healthcare providers and mothers to make the most educated choice regarding drug therapy and breast-feeding. 168 J PHARM TECHNOL I VOLUME 20 monitor for symptoms of rash and hematoma 64, 65 1 case of thrombocytopenia purpura and anemia concentrations in infants considered low Vigabatrin racemic mixture of S-enantiomer (active) and R-enantiomer not addressed 57 (inactive) has low molecular weight and is not protein bound maximum infant dose is 2-3.6% that of the maternal dose for the R-enantiomer and 0.6-0.96% of maternal dose for the S-enantiomer no cases of nursing infants exposed to drug use with caution and monitor infant Zonisamide (Zonegran) after a 300-mg dose, amount in milk equal to that in maternal not addressed 73 plasma readily transported into milk determine concentrations individually if breast-feeding AAP = American Academy of Pediatrics. a Some nurslings whose mothers are receiving antiepileptic therapy have increased sedation and may stop feeding early; this should be closely monitored.…”

Section: Discussionmentioning

confidence: 99%

Medications and Breast-Feeding: A Guide for Pharmacists, Pharmacy Technicians, and other Healthcare Professionals Part III

Nice

DeEugenio

DiMino

et al. 2004

Journal of Pharmacy Technology

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The following discussion of medication categories, including infectious diseases medications and vaccines, psychiatric and neurology agents, and radiopharmaceuticals, will help pharmacists and other healthcare professionals understand which are the optimal drugs within specific categories for breast-feeding mothers to take while minimizing the impact on infants. Drugs for use in ambulatory care, analgesia and anesthesia, and cardiology, as well as general medicines were discussed in Parts I 1 and II 2 of this 3-part series. Data and references supporting the information on each drug are detailed in tables, where applicable. American Academy of Pediatrics' (AAP) recommendations are listed if available. 3 Infectious Diseases ANTIINFECTIVESFortunately, most antibiotics, for various reasons, are generally considered safe for breast-feeding mothers to take. Infants, as well as mothers, should be monitored for FRANK J NICE MS MPA DPA CPHPObjective: To provide a guide for practicing pharmacists, pharmacy technicians, and other healthcare professionals so that they are able to counsel and advise breast-feeding mothers and fellow healthcare professionals on the safety and use of antiinfectives, vaccines, antiepileptics, benzodiazepines, psychotherapeutic drugs, and radiopharmaceuticals during breast-feeding. Data Sources: Primary texts used by the breast-feeding community (Medications and Mothers' Milk, Drugs in Pregnancy and Lactation, Drugs and Human Lactation)were searched, as well as Micromedex, MEDLINE, PubMed, EMBASE, and EMBASE2 (1984-February 2004). Study Selection/Data Extraction:Multiple sources were used wherever available to validate the data, and primary articles were used to verify all tertiary source information. Search terms included breast-feeding, lactation, nursing, and medications, as well as specific drug names.Data Synthesis: Concerns regarding medication use during breast-feeding have caused mothers to either discontinue nursing or not take necessary medications. Complete avoidance of medications or cessation of breast-feeding is often unnecessary. Although there are drugs that can be harmful to nursing infants, breastmilk concentrations of most drugs are insufficient to cause any harm. Conclusions:Having objective and reliable information on medications enables pharmacists, pharmacy technicians, other healthcare providers, and mothers to make educated decisions regarding drug therapy and breast-feeding.

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Section: Discussionmentioning

confidence: 99%