Potential Relevance of Vasoactive Intestinal Peptide to Ovarian Physiology

Ojeda, Sergio R.; Lara, Hernán; Ahmed, C. E.

doi:10.1055/s-2007-1021381

Cited by 27 publications

(4 citation statements)

References 34 publications

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“…It is also important to point out that because superior ovarian nerve is a mixed nerve that also contains other neurotransmitters (especially VIP) (40) we cannot rule out involvement of other neurotransmitters, in addition to NE, in maintaining the polycystic condition. In this regard, VIP has been described as a neuropeptide capable of stimulating estradiol secretion from the ovary (40). More studies are required to clarify the participation of the neuropeptide as an etiologic factor in the observed cystic ovaries.…”

Section: Role Of Sympathetic Ovarian Nerve Innervation In Facilitatinmentioning

confidence: 98%

Prepubertal Administration of Estradiol Valerate Disrupts Cyclicity and Leads to Cystic Ovarian Morphology during Adult Life in the Rat: Role of Sympathetic Innervation

et al. 2003

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Administration of estradiol valerate (EV) to adult rats leads to anovulation and cystic ovarian morphology. Sympathetic ovarian nerve denervation (SONX) overcomes this disruption. In this study, we determined whether EV administration to juvenile rats prevents achievement of reproductive competence, disrupts cyclicity, and whether this programming is facilitated via activation of the sympathetic nerve input to the ovary. Prepubertal rats were administered 2 mg EV in corn oil or corn oil alone. One half of the animals from each group underwent SONX on d 71 of life. Rats were euthanized on d 91 for determination of serum gonadotropins, progesterone, Delta4 androstenedione, and estradiol concentrations, ovarian norepinephrine (NE), and 3beta-hydroxysteroid dehydrogenase (3beta-HSD) activities and ovarian dynamics. Results revealed that EV administration during juvenile period advanced pubertal onset, suppressed circulating LH, FSH, and Delta4 androstenedione, increased ovarian NE, estradiol, and 3beta-HSD activities, disrupted ovarian dynamics evidenced as absent corpus luteum and presence of ovarian cysts and culminated in anovulation. SONX restored cyclicity in these animals, normalized LH, estradiol, ovarian 3beta-HSD activities, and ovarian dynamics as evidenced by the disappearance of ovarian cysts and appearance of corpus luteum and restored corpus luteum function. These findings provide evidence that EV exposure during juvenile life leads to long-lasting deleterious reproductive consequences via activation of the sympathetic ovarian nerve.

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Section: Role Of Sympathetic Ovarian Nerve Innervation In Facilitatinmentioning

confidence: 98%

Prepubertal Administration of Estradiol Valerate Disrupts Cyclicity and Leads to Cystic Ovarian Morphology during Adult Life in the Rat: Role of Sympathetic Innervation

et al. 2003

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“…Among the neurotransmitters delivered to the ovary via the extrinsic innervation of the gland, norepinephrine (NE) and vasoactive intestinal peptide (VIP) have been shown to be involved in the regulation of ovary-specific functions, such as steroidogenesis and early follicular development (Dissen et al 1993;Hsueh et al 1984;Mayerhofer et al 1997;Ojeda et al 1989). Among the neurotransmitters delivered to the ovary via the extrinsic innervation of the gland, norepinephrine (NE) and vasoactive intestinal peptide (VIP) have been shown to be involved in the regulation of ovary-specific functions, such as steroidogenesis and early follicular development (Dissen et al 1993;Hsueh et al 1984;Mayerhofer et al 1997;Ojeda et al 1989).…”

Section: Introductionmentioning

confidence: 99%

Intrinsic neurons in the rat ovary: an immunohistochemical study

D’Albora¹,

Lombide²,

Ojeda³

2000

Cell and Tissue Research

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Previous studies have shown the presence of neuronal perikarya in the primate ovary, but not in the ovary from Sprague-Dawley rats. We report here that while such intrinsic neurons are indeed absent in this strain of rats, they can be visualized in the ovary from Wistar rats. The neurons, identified by their morphology and by the expression of NeuN (a neuron-specific nuclear protein), were detected at all postnatal intervals examined, from 14 h after birth to 50 days of age. While they were present in the ovarian hilum and medulla at all ages studied, neurons first appeared in the ovarian cortex during the juvenile period (postnatal days 10-20). In all cases, the size of the neuronal soma increased significantly during prepubertal development, reaching maximal values before puberty. Some neurons were catecholaminergic, as indicated by their content of immunoreactive tyrosine hydroxylase (TH), the rate-limiting enzyme of catecholamine biosynthesis. Some showed neuropeptide Y (NPY) immunoreactivity. TH-positive neurons were seen either in isolation or clustered in ganglion-like structures in both the ovarian cortex and medulla. These results indicate that ovarian neurons are not present in all strains of rats, but when present, the chemical phenotype of some of them is of a sympathetic nature, similar to that described in primates.

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“…It has been demonstrated that the mammalian ovary is innervated by extrinsic nerves both catecholaminergic and peptidergic in nature (for reviews: [1][2][3]). Peptidergic innervation of the ovary is identified, among other ways, by the presence of vasoactive intestinal peptide (VIP) and neuropeptide Y (NPY) [4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Immunocytochemical Localization of Vasoactive Intestinal Peptide and Neuropeptide Y in the Bovine Ovary

Hulshof¹,

Dijkstra²,

Beek³

et al. 1994

Biology of Reproduction

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The distribution of the neuropeptides vasoactive intestinal peptide (VIP) and neuropeptide Y (NPY) was studied immunocytochemically in bovine ovaries from 3 mo of gestation up to and including puberty, and from adult cows at three stages of the estrous cycle. The appearance of VIP and NPY immunoreactivity of 4.5-6 mo of gestation coincided with the onset of follicular development. In contrast to NPY, VIP was first found in the cortex. Both VIP and NPY immunoreactivity increased with age. From 9 mo of gestation onwards, VIP and NPY were found around blood vessels and non-vascular smooth muscle cells, in the stroma near preantral follicles, and in the theca externa of antral follicles. In addition, VIP-positive cells were observed exclusively in the granulosa layer of the preovulatory follicle at the time of the LH surge. The distribution of VIP- and NPY-immunoreactive fibers in the ovary may point to an effect of these neuropeptides on various physiological processes, including follicle development and ovarian blood flow. In addition, the presence of VIP-positive cells in the granulosa layer of the preovulatory follicle is indicative of a role for VIP in ovulation.

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Potential Relevance of Vasoactive Intestinal Peptide to Ovarian Physiology

Cited by 27 publications

References 34 publications

Prepubertal Administration of Estradiol Valerate Disrupts Cyclicity and Leads to Cystic Ovarian Morphology during Adult Life in the Rat: Role of Sympathetic Innervation

Prepubertal Administration of Estradiol Valerate Disrupts Cyclicity and Leads to Cystic Ovarian Morphology during Adult Life in the Rat: Role of Sympathetic Innervation

Intrinsic neurons in the rat ovary: an immunohistochemical study

Immunocytochemical Localization of Vasoactive Intestinal Peptide and Neuropeptide Y in the Bovine Ovary

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