Potential repurposing of Favipiravir in COVID-19 outbreak based on current evidence

Khambholja, Kapil; Asudani, Deepak

doi:10.1016/j.tmaid.2020.101710

Cited by 30 publications

(26 citation statements)

References 1 publication

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“…It has been screened against many RNA viruses including H1N1, Ebola, Arena virus, and Bunyavirus because of its action against RNA viruses. It was however approved in Japan and France and not in other countries for a few indications [107].…”

Section: Favipiravir Favipiravir (Fpv)mentioning

confidence: 99%

Potential therapeutic targets for combating SARS-CoV-2: Drug repurposing, clinical trials and recent advancements

et al. 2020

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The present pandemic of SARS-CoV-2 has been a tough task for the whole world to deal with. With the absence of specific drugs or vaccines against SARS-CoV-2, the situation is very difficult to control. Apart from the absence of specific therapies, the lack of knowledge about potential therapeutic targets and individual perception is adding to the complications. The present review describes the novel SARS-CoV-2 structure, surface proteins, asymptomatic and symptomatic transmission in addition to the genotype and phenotype of SARS-CoV-2 along with genetic strains and similarity between SARS, MERS and SARS-CoV-2. Therapeutic strategies such as inhibition of the endocytic pathway and suppressing RNA polymerase activity by metal ions, which could be quite beneficial for controlling COVID-19, are outlined. The drug repurposing for SARS-CoV-2 is discussed in detail along with therapeutic classes such as antivirals, antibiotics, and amino quinolones and their probable role in suppressing SARS-CoV-2 with reference to case studies. The ongoing clinical trials both with respect to drug repurposing and vaccines are summarized along with a brief description. The recent advancements and future perspective of ongoing research for therapy and detection of SARS-CoV-2 are provided. The review, in brief, summarizes epidemiology, therapy and the current scenario for combating SARS-CoV-2.

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Section: Favipiravir Favipiravir (Fpv)mentioning

confidence: 99%

Potential therapeutic targets for combating SARS-CoV-2: Drug repurposing, clinical trials and recent advancements

et al. 2020

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“…Due to its successful antiviral potency, various researchers have made considerable efforts to modify, optimize, and develop facile and cost effective routes to the synthesis of favipiravir [12][13][14][15]. Sequel to the recent outbreak of the novel Coronavirus disease 2019 (COVID- 19), an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) across the world, favipiravir is investigated as one of the potential drugs for the experimental treatment of the novel coronavirus disease [16][17][18][19][20][21][22][23][24][25][26].…”

Section: Introductionmentioning

confidence: 99%

Theoretical studies of the rotational and tautomeric states, electronic and spectroscopic properties of favipiravir and its structural analogues: a potential drug for the treatment of COVID-19

Umar

2020

Journal of Taibah University for Science

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“… 112 It is currently assessed in more than 26 clinical trials ranging from phase II to IV, showing positive effects in shortening the treatment time and improving the lung condition of COVID-19 patients. 113 However, the Italian Pharmaceutical Agency has noted that it is too early for the available evidence to support this drug for COVID-19 treatment. 114 Danoprevir is an effective inhibitor of HCV protease (NS3/4A).…”

Section: Potential Therapeutic Strategiesmentioning

confidence: 99%

Recent Insights into Emerging Coronavirus: SARS-CoV-2

et al. 2020

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The SARS-CoV-2 outbreak that emerged at the end of 2019 has affected more than 58 million people with more than 1.38 million deaths and has had an incalculable impact on the world . Extensive prevention and treatment measures have been implemented since the pandemic. In this Review, we summarize current understanding on the source, transmission characteristics, and pathogenic mechanism of SARS-CoV-2. We also detail the recent development of diagnostic methods and potential treatment strategies of COVID-19 with focus on the ongoing clinical trials of antibodies, vaccines, and inhibitors for combating the emerging coronavirus.

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Potential repurposing of Favipiravir in COVID-19 outbreak based on current evidence

Cited by 30 publications

References 1 publication

Potential therapeutic targets for combating SARS-CoV-2: Drug repurposing, clinical trials and recent advancements

Potential therapeutic targets for combating SARS-CoV-2: Drug repurposing, clinical trials and recent advancements

Theoretical studies of the rotational and tautomeric states, electronic and spectroscopic properties of favipiravir and its structural analogues: a potential drug for the treatment of COVID-19

Recent Insights into Emerging Coronavirus: SARS-CoV-2

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