Efficient identification of favorable exploration lithofacies with commercial value is of utmost importance in lacustrine shale petroleum exploration. Shales deposited under different salinity conditions exhibit considerably different organic matter (OM) accumulation and mineral compositions. However, the systematic summarization of favorable exploration lithofacies and their formation mechanisms in lacustrine shale systems formed under different salinity conditions is still lacking. Herein, lacustrine shale of the Lower Jurassic Qianfoya Formation (J 1 q) from the Langzhong Area of the Sichuan Basin is studied to systematically reveal its OM accumulation mechanisms and the factors controlling its physical properties. By combining our data with that published in the literature, the favorable exploration lithofacies and their formation mechanisms in lacustrine shales deposited under various different salinities (i.e., freshwater, saline, and hypersaline) are discussed. Our findings indicate that the J 1 q shale comprises four lithofacies, namely, organic-lean mixed shale (LM), organic-lean argillaceous shale (LCM), organic-rich mixed shale (RM), and organic-rich argillaceous shale (RCM). The pore systems of RCM and RM are dominated by OM-related pores, whereas those of LCM and LM are dominated by clay mineral-related pores. The J 1 q shale was deposited in an oxic environment with a semiarid to semihumid climate, moderate weathering, and freshwater to brackish conditions. The OM content is primarily influenced by the relatively reductive environment. The physical properties of RCM and RM are primarily determined by the total organic carbon (TOC) content, whereas those of LCM and LM are determined by the clay mineral content. Additionally, a novel model for describing the change in the TOC content, pore system characteristics, and fracability of shale with an increase in salinity is proposed. The model shows that with an increase in salinity, the TOC content first decreases, then increases, and finally decreases. Simultaneously, there is an improvement in the proportion of framework-grain related pores within the pore system. RCM, RM, and tight sandstone and limestone interlayers within freshwater lacustrine shale can be regarded as primary sweet spots. In the saline and hypersaline lacustrine shale systems, the main exploration targets are RM and organic-rich calcareous shale. These observations provide theoretical guidance for locating sweet spots in lacustrine shale systems deposited under different salinity conditions.