Potential Risk Factors of Glioblastoma Multiforme in Greek Adults: A Case- Control Study

Chrysanthakopoulos, Nikolaos Andreas; Chrysanthakopoulos, Panagiotis Andreas

doi:10.46889/jcmr.2020.1204

Cited by 1 publication

(1 citation statement)

References 94 publications

(119 reference statements)

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“…One study of 68 GBM patients [113] was conducted to analyze the potential risk factors in the pathogenesis of glioblastoma. The application of the logistic regression model showed that, among others, a previous infection with HCMV was (in a statistically significant manner) associated with a glioblastoma risk.…”

Section: Additional Findingmentioning

confidence: 99%

Presence of the Human Cytomegalovirus in Glioblastomas—A Systematic Review

Peredo-Harvey

Rahbar

Söderberg‐Nauclér

2021

Cancers

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Glioblastoma is a malignant brain tumor with a dismal prognosis. The standard treatment has not changed in the past 15 years as clinical trials of new treatment protocols have failed. A high prevalence of the human cytomegalovirus (HCMV) in glioblastomas was first reported in 2002. The virus was found only in the tumor and not in the surrounding healthy brain tissue. Many groups have confirmed the presence of the HCMV in glioblastomas, but others could not. To resolve this discrepancy, we systematically reviewed 645 articles identified in different databases. Of these, 81 studies included results from 247 analyses of 9444 clinical samples (7024 tumor samples and 2420 blood samples) by different techniques, and 81 articles included 191 studies that identified the HCMV in 2529 tumor samples (36% of all tumor samples). HCMV proteins were often detected, whereas HCMV nucleic acids were not reliably detected by PCR methods. Optimized immunohistochemical techniques identified the virus in 1391 (84,2%) of 1653 samples. These data suggest that the HCMV is highly prevalent in glioblastomas and that optimized immunohistochemistry techniques are required to detect it.

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Section: Additional Findingmentioning

confidence: 99%