2006
DOI: 10.1111/j.1432-0436.2006.00079.x
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Potential role for insulin-like growth factor II and vitronectin in the endothelial–mesenchymal transition process

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Cited by 18 publications
(16 citation statements)
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“…Furthermore, DN-IGF-1R-injected embryos also showed a loss of restriction of bmp4 and notch1b to the atrioventricular boundary. Although this discovery represents a novel role for IGF-2 in zebrafish, previous work has demonstrated a role for IGF signalling in endothelial-tomesenchymal and epithelium-to-mesenchymal transitions, emphasising the importance of IGF signals in the molecular mechanisms underlying this process (Morali et al, 2001;Arciniegas et al, 2006).…”
Section: Igf-2b Is Required For Specification Of the Atrioventricularmentioning
confidence: 90%
“…Furthermore, DN-IGF-1R-injected embryos also showed a loss of restriction of bmp4 and notch1b to the atrioventricular boundary. Although this discovery represents a novel role for IGF-2 in zebrafish, previous work has demonstrated a role for IGF signalling in endothelial-tomesenchymal and epithelium-to-mesenchymal transitions, emphasising the importance of IGF signals in the molecular mechanisms underlying this process (Morali et al, 2001;Arciniegas et al, 2006).…”
Section: Igf-2b Is Required For Specification Of the Atrioventricularmentioning
confidence: 90%
“…47 Recently, we have shown that both IGFII and vitronectin may induce endothelial cell separation, detachment and migration involving relocation of VE-cadherin and β-catenin in vivo and in vitro, suggesting a fundamental role for these molecules during the EndoMT process. 39 Based on these asseverations and on the results derived from this study, we propose that stimulation of endothelial cells may lead to the loss of cell-cell contacts by removal of VE-cadherin and redistribution of β-catenin and to the activation and translocation of NFκB, and subsequent transformation into mesenchymal cells and regulation of α-SM actin expression.…”
Section: © 2 0 0 8 L a N D E S B I O S C I E N C E D O N O T D I S mentioning
confidence: 51%
“…Of note, IKKα activation followed by IκBα degradation and NFκB translocation has been described in endothelial cells exposed to shear stress, suggesting that this process is at least mediated by integrins such as α v β 3 integrin. 40 To this respect, the presence of α v β 3 and α v β 5 integrins in vivo in the intimal thickening and in vitro in separating, detaching and migrating cells has been reported by Arciniegas et al, 39 suggesting a key role for these molecules during the EndoMT process. Consistent with these findings, our observations support importance of the role for the activated NFκB during the EndoMT process, where IGFII fulfil a critical function, as we have recently demonstrated.…”
Section: Role Of Nfκb In Endothelial Mesenchymal Transitionmentioning
confidence: 81%
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